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Abnormal fetal cardiovascular physiology

MedGen UID:
1814350
•Concept ID:
C5676781
•
Finding
HPO: HP:0034190

Definition

Abnormal functionality of the fetal cardiovascular system. [from HPO]

Professional guidelines

PubMed

Challenges in diagnosis and management of coarctation of the aorta.
Chetan D, Mertens LL
Curr Opin Cardiol 2022 Jan 1;37(1):115-122. doi: 10.1097/HCO.0000000000000934. PMID: 34857719
Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn.
Singh Y, Lakshminrusimha S
Clin Perinatol 2021 Aug;48(3):595-618. doi: 10.1016/j.clp.2021.05.009. PMID: 34353582Free PMC Article
Update on PPHN: mechanisms and treatment.
Nair J, Lakshminrusimha S
Semin Perinatol 2014 Mar;38(2):78-91. doi: 10.1053/j.semperi.2013.11.004. PMID: 24580763Free PMC Article

Recent clinical studies

Etiology

Perinatal Cardiovascular Physiology and Recognition of Critical Congenital Heart Defects.
Singh Y, Lakshminrusimha S
Clin Perinatol 2021 Aug;48(3):573-594. doi: 10.1016/j.clp.2021.05.008. PMID: 34353581
Main Patterns of Fetal Cardiac Remodeling.
Crispi F, Sepúlveda-Martínez Á, Crovetto F, Gómez O, Bijnens B, Gratacós E
Fetal Diagn Ther 2020;47(5):337-344. Epub 2020 Mar 26 doi: 10.1159/000506047. PMID: 32213773
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Fetal Vascular Malperfusion.
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
Neonatal cardiovascular physiology.
Hines MH
Semin Pediatr Surg 2013 Nov;22(4):174-8. Epub 2013 Oct 14 doi: 10.1053/j.sempedsurg.2013.10.004. PMID: 24331090

Diagnosis

Perinatal Cardiovascular Physiology and Recognition of Critical Congenital Heart Defects.
Singh Y, Lakshminrusimha S
Clin Perinatol 2021 Aug;48(3):573-594. doi: 10.1016/j.clp.2021.05.008. PMID: 34353581
Fetal cardiovascular magnetic resonance imaging.
Aguet J, Seed M, Marini D
Pediatr Radiol 2020 Dec;50(13):1881-1894. Epub 2020 Nov 30 doi: 10.1007/s00247-020-04902-y. PMID: 33252756
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Fetal Vascular Malperfusion.
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
Antenatal foetal heart monitoring.
Murray H
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:2-11. Epub 2016 Oct 21 doi: 10.1016/j.bpobgyn.2016.10.008. PMID: 27866937

Therapy

Preeclampsia has two phenotypes which require different treatment strategies.
Masini G, Foo LF, Tay J, Wilkinson IB, Valensise H, Gyselaers W, Lees CC
Am J Obstet Gynecol 2022 Feb;226(2S):S1006-S1018. Epub 2021 Jun 10 doi: 10.1016/j.ajog.2020.10.052. PMID: 34774281
Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn.
Singh Y, Lakshminrusimha S
Clin Perinatol 2021 Aug;48(3):595-618. doi: 10.1016/j.clp.2021.05.009. PMID: 34353582Free PMC Article
Understanding the Pathophysiology, Implications, and Treatment Options of Patent Ductus Arteriosus in the Neonatal Population.
Conrad C, Newberry D
Adv Neonatal Care 2019 Jun;19(3):179-187. doi: 10.1097/ANC.0000000000000590. PMID: 30720481
Nutritional role of folate.
Ebara S
Congenit Anom (Kyoto) 2017 Sep;57(5):138-141. Epub 2017 Jul 25 doi: 10.1111/cga.12233. PMID: 28603928
Safe prevention of the primary cesarean delivery.
American College of Obstetricians and Gynecologists (College); Society for Maternal-Fetal Medicine, Caughey AB, Cahill AG, Guise JM, Rouse DJ
Am J Obstet Gynecol 2014 Mar;210(3):179-93. doi: 10.1016/j.ajog.2014.01.026. PMID: 24565430

Prognosis

Prenatal Diagnosis and Management of Single-Ventricle Heart Disease.
Freud LR, Seed M
Can J Cardiol 2022 Jul;38(7):897-908. Epub 2022 Apr 13 doi: 10.1016/j.cjca.2022.04.003. PMID: 35429589
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Cardiac function and dysfunction in the fetus.
Eckersley L, Hornberger LK
Echocardiography 2017 Dec;34(12):1776-1787. doi: 10.1111/echo.13654. PMID: 29287133
Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease.
Claessens NHP, Kelly CJ, Counsell SJ, Benders MJNL
Dev Med Child Neurol 2017 Sep;59(9):894-902. Epub 2017 May 19 doi: 10.1111/dmcn.13461. PMID: 28542743
Antenatal foetal heart monitoring.
Murray H
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:2-11. Epub 2016 Oct 21 doi: 10.1016/j.bpobgyn.2016.10.008. PMID: 27866937

Clinical prediction guides

Main Patterns of Fetal Cardiac Remodeling.
Crispi F, Sepúlveda-Martínez Á, Crovetto F, Gómez O, Bijnens B, Gratacós E
Fetal Diagn Ther 2020;47(5):337-344. Epub 2020 Mar 26 doi: 10.1159/000506047. PMID: 32213773
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Understanding the Pathophysiology, Implications, and Treatment Options of Patent Ductus Arteriosus in the Neonatal Population.
Conrad C, Newberry D
Adv Neonatal Care 2019 Jun;19(3):179-187. doi: 10.1097/ANC.0000000000000590. PMID: 30720481
Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease.
Claessens NHP, Kelly CJ, Counsell SJ, Benders MJNL
Dev Med Child Neurol 2017 Sep;59(9):894-902. Epub 2017 May 19 doi: 10.1111/dmcn.13461. PMID: 28542743
Antenatal foetal heart monitoring.
Murray H
Best Pract Res Clin Obstet Gynaecol 2017 Jan;38:2-11. Epub 2016 Oct 21 doi: 10.1016/j.bpobgyn.2016.10.008. PMID: 27866937

Recent systematic reviews

Systematic review of long QT syndrome identified during fetal life.
Chivers S, Ovadia C, Regan W, Zidere V, Vigneswaran T, Sharland G, Rosenthal E, Seed PT, Simpson JM, Williamson C
Heart Rhythm 2023 Apr;20(4):596-606. Epub 2022 Dec 22 doi: 10.1016/j.hrthm.2022.12.026. PMID: 36566891
Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.
Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M, Vaidya B, Chen L, Knight BA, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan CM, French R, Boucai L, Vafeiadi M, Grineva EN, Pop VJM, Vrijkotte TG, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Rebagliato M, Lu X, Pirzada A, Männistö T, Delles C, Feldt-Rasmussen U, Alexander EK, Nelson SM, Chaker L, Pearce EN, Guxens M, Steegers EAP, Walsh JP, Korevaar TIM
Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510. doi: 10.1016/S2213-8587(20)30061-9. PMID: 32445737Free PMC Article
Fetal heart rate monitoring in nonobstetric surgery: a systematic review of the evidence.
Higgins MF, Pollard L, McGuinness SK, Kingdom JC
Am J Obstet Gynecol MFM 2019 Nov;1(4):100048. Epub 2019 Sep 27 doi: 10.1016/j.ajogmf.2019.100048. PMID: 33345838
A systematic review of prenatal screening for congenital heart disease by fetal electrocardiography.
Verdurmen KM, Eijsvoogel NB, Lempersz C, Vullings R, Schroer C, van Laar JO, Oei SG
Int J Gynaecol Obstet 2016 Nov;135(2):129-134. Epub 2016 Aug 4 doi: 10.1016/j.ijgo.2016.05.010. PMID: 27634052
Fetal cerebro-placental ratio and adverse perinatal outcome: systematic review and meta-analysis of the association and diagnostic performance.
Nassr AA, Abdelmagied AM, Shazly SA
J Perinat Med 2016 Mar;44(2):249-56. doi: 10.1515/jpm-2015-0274. PMID: 26756084

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