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Anti-Zic4 antibody positivity

MedGen UID:
1814431
•Concept ID:
C5676868
•
Finding
Synonym: Anti-Zic4 antibody
 
HPO: HP:5000039

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Zic family member 4 (ZIC4). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-Zic4 antibody positivity

Recent clinical studies

Etiology

Atypical presentation of probable Creutzfeldt-Jakob disease associated with anti-Zic4 antibody: Literature review of neuronal antibodies in Creutzfeldt-Jakob disease.
Salazar R
Clin Neurol Neurosurg 2018 May;168:72-76. Epub 2018 Mar 5 doi: 10.1016/j.clineuro.2018.02.043. PMID: 29525731

Diagnosis

Autoimmune cerebellar hypermetabolism: Report of three cases and literature overview.
Brunet de Courssou JB, Castilla-Lievre MA, Maillot J, Brechemier ML, Ohlmann C, Sallansonnet-Froment M, Tafani C, Psimaras D, Ricard D, Bompaire F, Taifas I
Rev Neurol (Paris) 2022 Apr;178(4):337-346. Epub 2021 Oct 14 doi: 10.1016/j.neurol.2021.07.018. PMID: 34657731
Autoimmune encephalitis: the first observational study from Iran.
Etemadifar M, Aghababaei A, Nouri H, Kargaran PK, Mohammadi S, Salari M
Neurol Sci 2022 Feb;43(2):1239-1248. Epub 2021 Jul 30 doi: 10.1007/s10072-021-05400-1. PMID: 34328580
Case of anti-Zic4 antibody-mediated cerebellar toxicity induced by dual checkpoint inhibition in head and neck squamous cell carcinoma.
Iyer SG, Khakoo NS, Aitcheson G, Perez C
BMJ Case Rep 2020 Sep 17;13(9) doi: 10.1136/bcr-2020-235607. PMID: 32943444Free PMC Article
Atypical presentation of probable Creutzfeldt-Jakob disease associated with anti-Zic4 antibody: Literature review of neuronal antibodies in Creutzfeldt-Jakob disease.
Salazar R
Clin Neurol Neurosurg 2018 May;168:72-76. Epub 2018 Mar 5 doi: 10.1016/j.clineuro.2018.02.043. PMID: 29525731
Expression of ZIC family genes in meningiomas and other brain tumors.
Aruga J, Nozaki Y, Hatayama M, Odaka YS, Yokota N
BMC Cancer 2010 Mar 3;10:79. doi: 10.1186/1471-2407-10-79. PMID: 20199689Free PMC Article

Therapy

Case of anti-Zic4 antibody-mediated cerebellar toxicity induced by dual checkpoint inhibition in head and neck squamous cell carcinoma.
Iyer SG, Khakoo NS, Aitcheson G, Perez C
BMJ Case Rep 2020 Sep 17;13(9) doi: 10.1136/bcr-2020-235607. PMID: 32943444Free PMC Article

Clinical prediction guides

Autoimmune encephalitis: the first observational study from Iran.
Etemadifar M, Aghababaei A, Nouri H, Kargaran PK, Mohammadi S, Salari M
Neurol Sci 2022 Feb;43(2):1239-1248. Epub 2021 Jul 30 doi: 10.1007/s10072-021-05400-1. PMID: 34328580
Case of anti-Zic4 antibody-mediated cerebellar toxicity induced by dual checkpoint inhibition in head and neck squamous cell carcinoma.
Iyer SG, Khakoo NS, Aitcheson G, Perez C
BMJ Case Rep 2020 Sep 17;13(9) doi: 10.1136/bcr-2020-235607. PMID: 32943444Free PMC Article
Expression of ZIC family genes in meningiomas and other brain tumors.
Aruga J, Nozaki Y, Hatayama M, Odaka YS, Yokota N
BMC Cancer 2010 Mar 3;10:79. doi: 10.1186/1471-2407-10-79. PMID: 20199689Free PMC Article

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