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McConnell sign

MedGen UID:
1815081
•Concept ID:
C5706175
•
Finding
HPO: HP:0034331

Definition

Severe hypokinesia of the mid-free wall of the right ventricle of the heart with a normal contraction of the apical segment of the right ventricle. [from HPO]

Professional guidelines

PubMed

Echocardiography in the Risk Assessment of Acute Pulmonary Embolism.
Dahhan T, Alenezi F, Samad Z, Rajagopal S
Semin Respir Crit Care Med 2017 Feb;38(1):18-28. Epub 2017 Feb 16 doi: 10.1055/s-0036-1597563. PMID: 28208195

Recent clinical studies

Etiology

Left Ventricular Dysfunction Correlates With Mortality in Pulmonary Embolism.
Liteplo AS, Huang CK, Zheng H, Patel R, Ratanski D, Giordano NJ, Kabrhel C, Shokoohi H
J Emerg Med 2021 Feb;60(2):135-143. Epub 2020 Oct 27 doi: 10.1016/j.jemermed.2020.09.041. PMID: 33127261
Echocardiography in the Risk Assessment of Acute Pulmonary Embolism.
Dahhan T, Alenezi F, Samad Z, Rajagopal S
Semin Respir Crit Care Med 2017 Feb;38(1):18-28. Epub 2017 Feb 16 doi: 10.1055/s-0036-1597563. PMID: 28208195
Echocardiographic Pattern of Acute Pulmonary Embolism: Analysis of 511 Consecutive Patients.
Kurnicka K, Lichodziejewska B, Goliszek S, Dzikowska-Diduch O, Zdończyk O, Kozłowska M, Kostrubiec M, Ciurzyński M, Palczewski P, Grudzka K, Krupa M, Koć M, Pruszczyk P
J Am Soc Echocardiogr 2016 Sep;29(9):907-13. Epub 2016 Jul 15 doi: 10.1016/j.echo.2016.05.016. PMID: 27427291
Assessment of right ventricular systolic function by tissue Doppler echocardiography.
Kjærgaard J
Dan Med J 2012 Mar;59(3):B4409. PMID: 22381093
Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction.
Casazza F, Bongarzoni A, Capozi A, Agostoni O
Eur J Echocardiogr 2005 Jan;6(1):11-4. doi: 10.1016/j.euje.2004.06.002. PMID: 15664548

Diagnosis

The McConnell Sign is Seen in Patients With Acute Chest Syndrome.
McCutcheon JB, Schaffer P, Lyon M, Gordon R
J Ultrasound Med 2018 Oct;37(10):2433-2437. Epub 2018 Mar 2 doi: 10.1002/jum.14585. PMID: 29498079
Echocardiographic Pattern of Acute Pulmonary Embolism: Analysis of 511 Consecutive Patients.
Kurnicka K, Lichodziejewska B, Goliszek S, Dzikowska-Diduch O, Zdończyk O, Kozłowska M, Kostrubiec M, Ciurzyński M, Palczewski P, Grudzka K, Krupa M, Koć M, Pruszczyk P
J Am Soc Echocardiogr 2016 Sep;29(9):907-13. Epub 2016 Jul 15 doi: 10.1016/j.echo.2016.05.016. PMID: 27427291
McConnell's sign in intra-operative acute right ventricle ischaemia: An under-recognized aetiology.
Longo SA, Echegaray A, Acosta CM, Rinaldi LI, Cabrera Schulmeyer MC, Olavide Goya I
Rev Esp Anestesiol Reanim 2016 Nov;63(9):528-532. Epub 2016 Apr 5 doi: 10.1016/j.redar.2016.02.003. PMID: 27059509
Inverted McConnell sign.
de Agustín JA, Marcos-Alberca P, Fernández-Golfín C, Feltes G, Almería C, Macaya C, Zamorano J
Echocardiography 2012 Jul;29(6):E152-3. Epub 2012 Mar 9 doi: 10.1111/j.1540-8175.2012.01676.x. PMID: 22404547
Assessment of right ventricular systolic function by tissue Doppler echocardiography.
Kjærgaard J
Dan Med J 2012 Mar;59(3):B4409. PMID: 22381093

Therapy

McConnell sign: an indication for catheter-directed thrombolysis in pulmonary embolism.
Ahmed A, Bodapati R, Patel S
BMJ Case Rep 2020 Mar 12;13(3) doi: 10.1136/bcr-2019-233192. PMID: 32169985Free PMC Article
Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction.
Casazza F, Bongarzoni A, Capozi A, Agostoni O
Eur J Echocardiogr 2005 Jan;6(1):11-4. doi: 10.1016/j.euje.2004.06.002. PMID: 15664548

Prognosis

Left Ventricular Dysfunction Correlates With Mortality in Pulmonary Embolism.
Liteplo AS, Huang CK, Zheng H, Patel R, Ratanski D, Giordano NJ, Kabrhel C, Shokoohi H
J Emerg Med 2021 Feb;60(2):135-143. Epub 2020 Oct 27 doi: 10.1016/j.jemermed.2020.09.041. PMID: 33127261
The McConnell Sign is Seen in Patients With Acute Chest Syndrome.
McCutcheon JB, Schaffer P, Lyon M, Gordon R
J Ultrasound Med 2018 Oct;37(10):2433-2437. Epub 2018 Mar 2 doi: 10.1002/jum.14585. PMID: 29498079
Assessment of right ventricular systolic function by tissue Doppler echocardiography.
Kjærgaard J
Dan Med J 2012 Mar;59(3):B4409. PMID: 22381093
Echocardiographic predictors of pulmonary embolism in patients referred for helical CT.
Lodato JA, Ward RP, Lang RM
Echocardiography 2008 Jul;25(6):584-90. doi: 10.1111/j.1540-8175.2008.00665.x. PMID: 18652005
Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction.
Casazza F, Bongarzoni A, Capozi A, Agostoni O
Eur J Echocardiogr 2005 Jan;6(1):11-4. doi: 10.1016/j.euje.2004.06.002. PMID: 15664548

Clinical prediction guides

Left Ventricular Dysfunction Correlates With Mortality in Pulmonary Embolism.
Liteplo AS, Huang CK, Zheng H, Patel R, Ratanski D, Giordano NJ, Kabrhel C, Shokoohi H
J Emerg Med 2021 Feb;60(2):135-143. Epub 2020 Oct 27 doi: 10.1016/j.jemermed.2020.09.041. PMID: 33127261
Right Ventricular Systolic Function Responses to Acute and Chronic Pulmonary Hypertension: Assessment with Myocardial Deformation.
Wright L, Dwyer N, Power J, Kritharides L, Celermajer D, Marwick TH
J Am Soc Echocardiogr 2016 Mar;29(3):259-66. doi: 10.1016/j.echo.2015.11.010. PMID: 26944627
Assessment of right ventricular systolic function by tissue Doppler echocardiography.
Kjærgaard J
Dan Med J 2012 Mar;59(3):B4409. PMID: 22381093
Right ventricular apical contractility in acute pulmonary embolism: the McConnell sign revisited.
López-Candales A, Edelman K, Candales MD
Echocardiography 2010 Jul;27(6):614-20. Epub 2010 Jun 16 doi: 10.1111/j.1540-8175.2009.01103.x. PMID: 20561014
Echocardiographic predictors of pulmonary embolism in patients referred for helical CT.
Lodato JA, Ward RP, Lang RM
Echocardiography 2008 Jul;25(6):584-90. doi: 10.1111/j.1540-8175.2008.00665.x. PMID: 18652005

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