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Reduced circulating prekallikrein concentration

MedGen UID:
1815101
•Concept ID:
C5706195
•
Finding
HPO: HP:0034371

Definition

Reduced concentration of prekallikrein (PK; also known as Fletcher factor) in the blood circulation. PK is the precursor of plasma kallikrein, a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating prekallikrein concentration

Conditions with this feature

Inherited prekallikrein deficiency
MedGen UID:
987194
•Concept ID:
CN305372
•
Disease or Syndrome
Prekallikrein deficiency (PKKD) is a rare asymptomatic clotting defect characterized by prolongation of activated partial thromboplastin time (summary by Saito et al., 1981).
See: Condition Record
Inherited prekallikrein deficiency

Recent clinical studies

Etiology

Effect of the serine protease inhibitor, aprotinin, on systemic haemodynamics and renal function in patients with hepatic cirrhosis and ascites.
MacGilchrist A, Craig KJ, Hayes PC, Cumming AD
Clin Sci (Lond) 1994 Sep;87(3):329-35. doi: 10.1042/cs0870329. PMID: 7525142
Aprotinin in cardiopulmonary bypass--effects on the Hageman factor (FXII)--Kallikrein system and blood loss.
Fuhrer G, Gallimore MJ, Heller W, Hoffmeister HE
Blood Coagul Fibrinolysis 1992 Feb;3(1):99-104. doi: 10.1097/00001721-199202000-00014. PMID: 1377956
Plasma and tissue kallikrein-kinin systems during acute administration of frusemide in normotensive and hypertensive humans.
Ohman KP, Karlberg BE
Clin Sci (Lond) 1991 Sep;81(3):305-11. doi: 10.1042/cs0810305. PMID: 1655330

Therapy

Effect of the serine protease inhibitor, aprotinin, on systemic haemodynamics and renal function in patients with hepatic cirrhosis and ascites.
MacGilchrist A, Craig KJ, Hayes PC, Cumming AD
Clin Sci (Lond) 1994 Sep;87(3):329-35. doi: 10.1042/cs0870329. PMID: 7525142
Aprotinin in cardiopulmonary bypass--effects on the Hageman factor (FXII)--Kallikrein system and blood loss.
Fuhrer G, Gallimore MJ, Heller W, Hoffmeister HE
Blood Coagul Fibrinolysis 1992 Feb;3(1):99-104. doi: 10.1097/00001721-199202000-00014. PMID: 1377956

Clinical prediction guides

Aprotinin in cardiopulmonary bypass--effects on the Hageman factor (FXII)--Kallikrein system and blood loss.
Fuhrer G, Gallimore MJ, Heller W, Hoffmeister HE
Blood Coagul Fibrinolysis 1992 Feb;3(1):99-104. doi: 10.1097/00001721-199202000-00014. PMID: 1377956

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