From HPO
Classic Hodgkin lymphoma- MedGen UID:
- 9283
- •Concept ID:
- C0019829
- •
- Neoplastic Process
Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).
Pancytopenia- MedGen UID:
- 18281
- •Concept ID:
- C0030312
- •
- Disease or Syndrome
An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).
Hypofibrinogenemia- MedGen UID:
- 107511
- •Concept ID:
- C0553681
- •
- Disease or Syndrome
Decreased concentration of fibrinogen in the blood.
Bronchiectasis- MedGen UID:
- 14234
- •Concept ID:
- C0006267
- •
- Disease or Syndrome
Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.
Recurrent sinusitis- MedGen UID:
- 107919
- •Concept ID:
- C0581354
- •
- Disease or Syndrome
A recurrent form of sinusitis.
Recurrent lower respiratory tract infections- MedGen UID:
- 756211
- •Concept ID:
- C3163798
- •
- Disease or Syndrome
An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.
Splenomegaly- MedGen UID:
- 52469
- •Concept ID:
- C0038002
- •
- Finding
Abnormal increased size of the spleen.
Generalized lymphadenopathy- MedGen UID:
- 96909
- •Concept ID:
- C0476486
- •
- Finding
A generalized form of lymphadenopathy.
Persistent EBV viremia- MedGen UID:
- 767466
- •Concept ID:
- C3554552
- •
- Finding
Persistent presence of Epstein-Barr virus in the blood.
Absent circulating B cells- MedGen UID:
- 868166
- •Concept ID:
- C4022558
- •
- Finding
Complete lack of mature B cells, that is, of B cells that have left the bone marrow.
Decreased specific pneumococcal antibody level- MedGen UID:
- 868496
- •Concept ID:
- C4022890
- •
- Finding
The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci.
Decreased lymphocyte proliferation in response to anti-CD3- MedGen UID:
- 1614554
- •Concept ID:
- C4531165
- •
- Finding
A decreased proliferative response of lymphocytes in vitro or in vivo, when stimulated with an anti-CD3 antibody against the T-cell co-receptor, CD3.
Complete or near-complete absence of specific antibody response to tetanus vaccine- MedGen UID:
- 1687415
- •Concept ID:
- C5139458
- •
- Finding
The inability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.
Decreased circulating IgG level- MedGen UID:
- 1720114
- •Concept ID:
- C5234937
- •
- Finding
An abnormally decreased level of immunoglobulin G (IgG) in blood.
Hypertriglyceridemia- MedGen UID:
- 167238
- •Concept ID:
- C0813230
- •
- Finding
An abnormal increase in the level of triglycerides in the blood.
- Abnormality of blood and blood-forming tissues
- Abnormality of metabolism/homeostasis
- Abnormality of the immune system
- Abnormality of the respiratory system
- Neoplasm