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Reduced frequency of facial expressions

MedGen UID:
1841531
•Concept ID:
C5826843
•
Finding
HPO: HP:4000075

Definition

The number of times facial expressions are produced in a given period is lower than expected given the social and cultural context. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced frequency of facial expressions

Professional guidelines

PubMed

ACTN3 R577X genotypes associate with Class II and deepbite malocclusions.
Zebrick B, Teeramongkolgul T, Nicot R, Horton MJ, Raoul G, Ferri J, Vieira AR, Sciote JJ
Am J Orthod Dentofacial Orthop 2014 Nov;146(5):603-11. Epub 2014 Oct 28 doi: 10.1016/j.ajodo.2014.07.021. PMID: 25439211Free PMC Article
Effects of the Lee Silverman Voice Treatment (LSVT® LOUD) on hypomimia in Parkinson's disease.
Dumer AI, Oster H, McCabe D, Rabin LA, Spielman JL, Ramig LO, Borod JC
J Int Neuropsychol Soc 2014 Mar;20(3):302-12. Epub 2014 Feb 13 doi: 10.1017/S1355617714000046. PMID: 24524211
Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment.
Pantazatos SP, Talati A, Schneier FR, Hirsch J
Neuropsychopharmacology 2014 Jan;39(2):425-34. Epub 2013 Aug 20 doi: 10.1038/npp.2013.211. PMID: 24084831Free PMC Article

Recent clinical studies

Etiology

Neural sensitivity to facial identity and facial expression discrimination in adults with autism.
Van der Donck S, Hendriks M, Vos S, Op de Beeck H, Boets B
Autism Res 2023 Nov;16(11):2110-2124. Epub 2023 Oct 12 doi: 10.1002/aur.3036. PMID: 37823568
Dissecting the Complexity of Skeletal-Malocclusion-Associated Phenotypes: Mouse for the Rescue.
Lone IM, Zohud O, Nashef A, Kirschneck C, Proff P, Watted N, Iraqi FA
Int J Mol Sci 2023 Jan 29;24(3) doi: 10.3390/ijms24032570. PMID: 36768894Free PMC Article
Multifaceted empathy differences in children and adults with autism.
Quinde-Zlibut JM, Williams ZJ, Gerdes M, Mash LE, Heflin BH, Cascio C
Sci Rep 2021 Sep 30;11(1):19503. doi: 10.1038/s41598-021-98516-5. PMID: 34593865Free PMC Article
Impact of lower motor neurone facial palsy on oro-motor function and its remediation.
Venables V, Neville C, Gwynn T, Kannan RY, Nduka C
J Plast Reconstr Aesthet Surg 2019 Sep;72(9):1570-1575. Epub 2019 May 22 doi: 10.1016/j.bjps.2019.05.023. PMID: 31178330
The level of cognitive function and recognition of emotions in older adults.
Virtanen M, Singh-Manoux A, Batty GD, Ebmeier KP, Jokela M, Harmer CJ, Kivimäki M
PLoS One 2017;12(10):e0185513. Epub 2017 Oct 4 doi: 10.1371/journal.pone.0185513. PMID: 28977015Free PMC Article

Diagnosis

Neural sensitivity to facial identity and facial expression discrimination in adults with autism.
Van der Donck S, Hendriks M, Vos S, Op de Beeck H, Boets B
Autism Res 2023 Nov;16(11):2110-2124. Epub 2023 Oct 12 doi: 10.1002/aur.3036. PMID: 37823568
Multifaceted empathy differences in children and adults with autism.
Quinde-Zlibut JM, Williams ZJ, Gerdes M, Mash LE, Heflin BH, Cascio C
Sci Rep 2021 Sep 30;11(1):19503. doi: 10.1038/s41598-021-98516-5. PMID: 34593865Free PMC Article
Facial expressions of pain in daily clinical practice to assess postoperative pain in children: Reliability and validity of the facial action summary score.
Bringuier S, Macioce V, Boulhais M, Dadure C, Capdevila X
Eur J Pain 2021 May;25(5):1081-1090. Epub 2021 Jan 26 doi: 10.1002/ejp.1729. PMID: 33428820
Variation in recognition of happy and sad facial expressions and self-reported depressive symptom severity: A prospective cohort study.
Bone JK, Lewis G, Button KS, Duffy L, Harmer CJ, Munafò MR, Penton-Voak IS, Wiles NJ, Lewis G
J Affect Disord 2019 Oct 1;257:461-469. Epub 2019 Jun 22 doi: 10.1016/j.jad.2019.06.025. PMID: 31310908
Asymmetric neural responses for facial expressions and anti-expressions.
Gwinn OS, Matera CN, O'Neil SF, Webster MA
Neuropsychologia 2018 Oct;119:405-416. Epub 2018 Sep 5 doi: 10.1016/j.neuropsychologia.2018.09.001. PMID: 30193846Free PMC Article

Therapy

Can repeated intranasal oxytocin administration affect reduced neural sensitivity towards expressive faces in autism? A randomized controlled trial.
Moerkerke M, Daniels N, Van der Donck S, Tibermont L, Tang T, Debbaut E, Bamps A, Prinsen J, Steyaert J, Alaerts K, Boets B
J Child Psychol Psychiatry 2023 Nov;64(11):1583-1595. Epub 2023 Jun 6 doi: 10.1111/jcpp.13850. PMID: 37278339
Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study.
Bach P, Koopmann A, Bumb JM, Zimmermann S, Bühler S, Reinhard I, Witt SH, Rietschel M, Vollstädt-Klein S, Kiefer F
Eur Arch Psychiatry Clin Neurosci 2021 Aug;271(5):873-882. Epub 2020 Feb 19 doi: 10.1007/s00406-020-01115-0. PMID: 32076819Free PMC Article
Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.
Sachs DL, Varani J, Chubb H, Fligiel SEG, Cui Y, Calderone K, Helfrich Y, Fisher GJ, Voorhees JJ
J Am Acad Dermatol 2019 Aug;81(2):480-488. Epub 2019 Apr 5 doi: 10.1016/j.jaad.2019.03.081. PMID: 30954583
Botulinum toxin therapy of hemifacial spasm: bilateral injections can reduce facial asymmetry.
Xiao L, Pan L, Li B, Zhou Y, Pan Y, Zhang X, Hu Y, Dressler D, Jin L
J Neurol 2018 Sep;265(9):2097-2105. Epub 2018 Jul 9 doi: 10.1007/s00415-018-8960-2. PMID: 29987587
Molecular Pathogenesis of Chewable Tobacco.
Baig S, Rubab Z, Farooq W
J Coll Physicians Surg Pak 2018 May;28(5):381-385. doi: 10.29271/jcpsp.2018.05.381. PMID: 29690969

Prognosis

Multifaceted empathy differences in children and adults with autism.
Quinde-Zlibut JM, Williams ZJ, Gerdes M, Mash LE, Heflin BH, Cascio C
Sci Rep 2021 Sep 30;11(1):19503. doi: 10.1038/s41598-021-98516-5. PMID: 34593865Free PMC Article
Time course of attentional bias in social anxiety: The effects of spatial frequencies and individual threats.
Dong X, Gao C, Guo C, Li W, Cui L
Psychophysiology 2020 Sep;57(9):e13617. Epub 2020 Jun 17 doi: 10.1111/psyp.13617. PMID: 32557636
Victimization, violence and facial affect recognition in a community sample of first-episode psychosis patients.
Hachtel H, Fullam R, Malone A, Murphy BP, Huber C, Carroll A
Early Interv Psychiatry 2020 Jun;14(3):283-292. Epub 2019 Jul 2 doi: 10.1111/eip.12853. PMID: 31264789
Impact of lower motor neurone facial palsy on oro-motor function and its remediation.
Venables V, Neville C, Gwynn T, Kannan RY, Nduka C
J Plast Reconstr Aesthet Surg 2019 Sep;72(9):1570-1575. Epub 2019 May 22 doi: 10.1016/j.bjps.2019.05.023. PMID: 31178330
Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.
Sachs DL, Varani J, Chubb H, Fligiel SEG, Cui Y, Calderone K, Helfrich Y, Fisher GJ, Voorhees JJ
J Am Acad Dermatol 2019 Aug;81(2):480-488. Epub 2019 Apr 5 doi: 10.1016/j.jaad.2019.03.081. PMID: 30954583

Clinical prediction guides

Neural sensitivity to facial identity and facial expression discrimination in adults with autism.
Van der Donck S, Hendriks M, Vos S, Op de Beeck H, Boets B
Autism Res 2023 Nov;16(11):2110-2124. Epub 2023 Oct 12 doi: 10.1002/aur.3036. PMID: 37823568
WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.
Hao L, Ma J, Wu F, Ma X, Qian M, Sheng W, Yan T, Tang N, Jiang X, Zhang B, Xiao D, Qian Y, Zhang J, Jiang N, Zhou W, Chen W, Ma D, Huang G
Clin Transl Med 2022 Jul;12(7):e941. doi: 10.1002/ctm2.941. PMID: 35808830Free PMC Article
Multifaceted empathy differences in children and adults with autism.
Quinde-Zlibut JM, Williams ZJ, Gerdes M, Mash LE, Heflin BH, Cascio C
Sci Rep 2021 Sep 30;11(1):19503. doi: 10.1038/s41598-021-98516-5. PMID: 34593865Free PMC Article
Facial expressions of pain in daily clinical practice to assess postoperative pain in children: Reliability and validity of the facial action summary score.
Bringuier S, Macioce V, Boulhais M, Dadure C, Capdevila X
Eur J Pain 2021 May;25(5):1081-1090. Epub 2021 Jan 26 doi: 10.1002/ejp.1729. PMID: 33428820
Asymmetric neural responses for facial expressions and anti-expressions.
Gwinn OS, Matera CN, O'Neil SF, Webster MA
Neuropsychologia 2018 Oct;119:405-416. Epub 2018 Sep 5 doi: 10.1016/j.neuropsychologia.2018.09.001. PMID: 30193846Free PMC Article

Recent systematic reviews

Impact of SARS-CoV-2 Virus (COVID-19) Preventative Measures on Communication: A Scoping Review.
Oosthuizen I, Saunders GH, Manchaiah V, Swanepoel W
Front Public Health 2022;10:815259. Epub 2022 Mar 28 doi: 10.3389/fpubh.2022.815259. PMID: 35419343Free PMC Article
Music Interventions for Disorders of Consciousness: A Systematic Review and Meta-analysis.
Li X, Li C, Hu N, Wang T
J Neurosci Nurs 2020 Aug;52(4):146-151. doi: 10.1097/JNN.0000000000000511. PMID: 32404771

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