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Abnormal liver metabolite concentration

MedGen UID:
1841588
Concept ID:
C5826554
Finding
HPO: HP:0034644

Definition

The concentration of a metabolite in the liver is above or below the limits of normal. [from HPO]

Professional guidelines

PubMed

Wang T, Zhou Y, Cao G
Eur J Clin Pharmacol 2021 Aug;77(8):1095-1111. Epub 2021 Jan 29 doi: 10.1007/s00228-021-03088-y. PMID: 33515076
Barić I, Staufner C, Augoustides-Savvopoulou P, Chien YH, Dobbelaere D, Grünert SC, Opladen T, Petković Ramadža D, Rakić B, Wedell A, Blom HJ
J Inherit Metab Dis 2017 Jan;40(1):5-20. Epub 2016 Sep 26 doi: 10.1007/s10545-016-9972-7. PMID: 27671891Free PMC Article
Lee MH, Graham GG, Williams KM, Day RO
Drug Saf 2008;31(8):643-65. doi: 10.2165/00002018-200831080-00002. PMID: 18636784

Recent clinical studies

Etiology

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Zeisel S
Nutrients 2017 Apr 29;9(5) doi: 10.3390/nu9050445. PMID: 28468239Free PMC Article
Sitkin SI, Tkachenko EI, Vakhitov TY
Eksp Klin Gastroenterol 2016 Jul;12(12):6-29. PMID: 29889418
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Poppers PJ
Anaesthesist 1980 Feb;29(2):55-8. PMID: 6990824

Diagnosis

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Li M, Liu S, Wang M, Hu H, Yin J, Liu C, Huang Y
Sci Rep 2020 May 6;10(1):7686. doi: 10.1038/s41598-020-64728-4. PMID: 32377002Free PMC Article
Barić I, Staufner C, Augoustides-Savvopoulou P, Chien YH, Dobbelaere D, Grünert SC, Opladen T, Petković Ramadža D, Rakić B, Wedell A, Blom HJ
J Inherit Metab Dis 2017 Jan;40(1):5-20. Epub 2016 Sep 26 doi: 10.1007/s10545-016-9972-7. PMID: 27671891Free PMC Article
Perman WH, Balci NC, Akduman I
Top Magn Reson Imaging 2009 Apr;20(2):89-97. doi: 10.1097/RMR.0b013e3181c422f1. PMID: 20010063
Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG
Am J Hum Genet 1995 Oct;57(4):882-92. PMID: 7573050Free PMC Article

Therapy

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Kletzl H, Ajmi H, Antys I, Heinig K, Jaber B, Marbury TC, Young A, Günther A
Br J Clin Pharmacol 2022 Aug;88(8):3749-3759. Epub 2022 Apr 1 doi: 10.1111/bcp.15319. PMID: 35301746Free PMC Article
Wang T, Zhou Y, Cao G
Eur J Clin Pharmacol 2021 Aug;77(8):1095-1111. Epub 2021 Jan 29 doi: 10.1007/s00228-021-03088-y. PMID: 33515076
Wilson RG, Davis RE
Adv Clin Chem 1983;23:1-68. doi: 10.1016/s0065-2423(08)60397-2. PMID: 6398613
Poppers PJ
Anaesthesist 1980 Feb;29(2):55-8. PMID: 6990824

Prognosis

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047
Sookoian S, Pirola CJ
World J Gastroenterol 2012 Aug 7;18(29):3775-81. doi: 10.3748/wjg.v18.i29.3775. PMID: 22876026Free PMC Article
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG
Am J Hum Genet 1995 Oct;57(4):882-92. PMID: 7573050Free PMC Article

Clinical prediction guides

Prescott LF
Br J Clin Pharmacol 2024 Jan;90(1):127-134. Epub 2023 Sep 21 doi: 10.1111/bcp.15903. PMID: 37683599
Córdoba-Jover B, Ribera J, Portolés I, Lecue E, Rodriguez-Vita J, Pérez-Sisqués L, Mannara F, Solsona-Vilarrasa E, García-Ruiz C, Fernández-Checa JC, Casals G, Rodríguez-Revenga L, Álvarez-Mora MI, Arteche-López A, Díaz de Bustamante A, Calvo R, Pujol A, Azkargorta M, Elortza F, Malagelada C, Pinyol R, Huguet-Pradell J, Melgar-Lesmes P, Jiménez W, Morales-Ruiz M
Liver Int 2023 Aug;43(8):1822-1836. Epub 2023 Jun 14 doi: 10.1111/liv.15640. PMID: 37312667
Schwasinger-Schmidt TE, Macaluso M
Handb Exp Pharmacol 2019;250:325-355. doi: 10.1007/164_2018_167. PMID: 30194544
Lattuada G, Ragogna F, Perseghin G
Curr Diab Rep 2011 Jun;11(3):167-72. doi: 10.1007/s11892-011-0190-2. PMID: 21431854
Kumar R
Physiol Rev 1984 Apr;64(2):478-504. doi: 10.1152/physrev.1984.64.2.478. PMID: 6324253

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