U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spheroid bodies

MedGen UID:
1841598
Concept ID:
C5826440
Finding
HPO: HP:0034509

Definition

An accumulation of myofilamentous material within individual muscle fibers, forming usually round but occasionally elongated bodies ranging from 2 to 15 pm in size. The so-called spheroid bodies stain green with the modified trichrome preparation and are mainly present in the periphery of type 1 muscle fibers, where they may occupy large sectors sharply demarcated from the remainder of the cross-sectioned muscle fiber. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Jayme CC, Pires AF, Fernandes DS, Bi H, Tedesco AC
Photodiagnosis Photodyn Ther 2022 Mar;37:102575. Epub 2021 Oct 7 doi: 10.1016/j.pdpdt.2021.102575. PMID: 34628073
Johnson KA, DeStefanis RA, Emmerich PB, Grogan PT, Kratz JD, Makkar SK, Clipson L, Deming DA
Curr Treat Options Oncol 2020 Apr 23;21(5):35. doi: 10.1007/s11864-020-00737-9. PMID: 32328818Free PMC Article
Zhang L, Zhang Y, Tai L, Jiang K, Xie C, Li Z, Lin YZ, Wei G, Lu W, Pan W
Acta Biomater 2016 Sep 15;42:90-101. Epub 2016 Jun 29 doi: 10.1016/j.actbio.2016.06.031. PMID: 27370905

Recent clinical studies

Etiology

Kruer MC, Hiken M, Gregory A, Malandrini A, Clark D, Hogarth P, Grafe M, Hayflick SJ, Woltjer RL
Brain 2011 Apr;134(Pt 4):947-58. doi: 10.1093/brain/awr042. PMID: 21459825Free PMC Article
Chang CM, Kao CL, Chang YL, Yang MJ, Chen YC, Sung BL, Tsai TH, Chao KC, Chiou SH, Ku HH
Biochem Biophys Res Commun 2007 Jun 1;357(2):414-20. Epub 2007 Apr 3 doi: 10.1016/j.bbrc.2007.03.157. PMID: 17433254
Lui PC, Luk IS, Lee CK, Lui YH, Leung CY, Choi CH
J Clin Pathol 2004 Feb;57(2):155-8. doi: 10.1136/jcp.2003.11965. PMID: 14747440Free PMC Article
Goebel HH, Warlo IA
J Child Neurol 2000 Sep;15(9):565-72. doi: 10.1177/088307380001500901. PMID: 11019786
Itoh M, Hayashi M, Shioda K, Minagawa M, Isa F, Tamagawa K, Morimatsu Y, Oda M
Brain Dev 1999 Jul;21(5):326-33. doi: 10.1016/s0387-7604(99)00033-9. PMID: 10413020

Diagnosis

Lui PC, Luk IS, Lee CK, Lui YH, Leung CY, Choi CH
J Clin Pathol 2004 Feb;57(2):155-8. doi: 10.1136/jcp.2003.11965. PMID: 14747440Free PMC Article
Goebel HH
Curr Opin Neurol 1997 Oct;10(5):426-9. doi: 10.1097/00019052-199710000-00012. PMID: 9330890
Goebel HH, Husmann G, Voit T, Calişkan M
Turk J Pediatr 1994 Jul-Sep;36(3):223-37. PMID: 7974813
Aicardi J, Castelein P
Brain 1979 Dec;102(4):727-48. doi: 10.1093/brain/102.4.727. PMID: 509195
Zarkowsky HS, Mohandas N, Speaker CB, Shohet SB
Br J Haematol 1975 Apr;29(4):537-43. doi: 10.1111/j.1365-2141.1975.tb02740.x. PMID: 1191563

Therapy

Lui PC, Luk IS, Lee CK, Lui YH, Leung CY, Choi CH
J Clin Pathol 2004 Feb;57(2):155-8. doi: 10.1136/jcp.2003.11965. PMID: 14747440Free PMC Article
Itoh M, Hayashi M, Shioda K, Minagawa M, Isa F, Tamagawa K, Morimatsu Y, Oda M
Brain Dev 1999 Jul;21(5):326-33. doi: 10.1016/s0387-7604(99)00033-9. PMID: 10413020
Yamaguchi K, Handa T
Pediatr Neurol 1998 Apr;18(4):338-41. doi: 10.1016/s0887-8994(97)00192-6. PMID: 9588531
Arai N
Neuropathol Appl Neurobiol 1995 Jun;21(3):238-45. doi: 10.1111/j.1365-2990.1995.tb01055.x. PMID: 7477732

Prognosis

Lui PC, Luk IS, Lee CK, Lui YH, Leung CY, Choi CH
J Clin Pathol 2004 Feb;57(2):155-8. doi: 10.1136/jcp.2003.11965. PMID: 14747440Free PMC Article
Oygür T, Dolanmaz D, Tokman B, Bayraktar S
J Oral Pathol Med 2001 Sep;30(8):504-6. doi: 10.1034/j.1600-0714.2001.030008504.x. PMID: 11545243
Yamaguchi K, Handa T
Pediatr Neurol 1998 Apr;18(4):338-41. doi: 10.1016/s0887-8994(97)00192-6. PMID: 9588531
Arai N, Yagishita S, Misugi K, Oda M, Kosaka K, Mizutani T, Morimatsu Y
Virchows Arch A Pathol Anat Histopathol 1992;420(3):243-52. doi: 10.1007/BF01600277. PMID: 1553816
Aicardi J, Castelein P
Brain 1979 Dec;102(4):727-48. doi: 10.1093/brain/102.4.727. PMID: 509195

Clinical prediction guides

Karicheva O, Rodriguez-Vargas JM, Wadier N, Martin-Hernandez K, Vauchelles R, Magroun N, Tissier A, Schreiber V, Dantzer F
Oncotarget 2016 Sep 27;7(39):64109-64123. doi: 10.18632/oncotarget.11627. PMID: 27579892Free PMC Article
Chang CM, Kao CL, Chang YL, Yang MJ, Chen YC, Sung BL, Tsai TH, Chao KC, Chiou SH, Ku HH
Biochem Biophys Res Commun 2007 Jun 1;357(2):414-20. Epub 2007 Apr 3 doi: 10.1016/j.bbrc.2007.03.157. PMID: 17433254
Baeta AM, Figarella-Branger D, Bille-Turc F, Lepidi H, Pellissier JF
Acta Neuropathol 1996 Nov;92(5):499-510. doi: 10.1007/s004010050552. PMID: 8922062
Arai N
Neuropathol Appl Neurobiol 1995 Jun;21(3):238-45. doi: 10.1111/j.1365-2990.1995.tb01055.x. PMID: 7477732
Arai N, Mizutani T, Morimatsu Y
Virchows Arch A Pathol Anat Histopathol 1993;422(4):307-11. doi: 10.1007/BF01608340. PMID: 8506624

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...