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Reduced epidermal keratin 10 protein expression

MedGen UID:
1841612
•Concept ID:
C5826489
•
Finding
HPO: HP:0034574

Definition

Amount of keratin 10 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced epidermal keratin 10 protein expression

Recent clinical studies

Etiology

Hyaluronic acid-fibrin hydrogels show improved mechanical stability in dermo-epidermal skin substitutes.
Montero A, Atienza C, Elvira C, Jorcano JL, Velasco D
Mater Sci Eng C Mater Biol Appl 2021 Sep;128:112352. Epub 2021 Jul 31 doi: 10.1016/j.msec.2021.112352. PMID: 34474900
An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17.
Donetti E, Cornaghi L, Gualerzi A, Baruffaldi Preis FW, Prignano F
Cytokine 2014 Jul;68(1):1-8. Epub 2014 Apr 6 doi: 10.1016/j.cyto.2014.03.003. PMID: 24787050
Immunohistochemical differentiation between inflammatory linear verrucous epidermal nevus (ILVEN) and psoriasis.
Vissers WH, Muys L, Erp PE, de Jong EM, van de Kerkhof PC
Eur J Dermatol 2004 Jul-Aug;14(4):216-20. PMID: 15319153
Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.
O'Brien LM, Walsh EJ, Massey RC, Peacock SJ, Foster TJ
Cell Microbiol 2002 Nov;4(11):759-70. doi: 10.1046/j.1462-5822.2002.00231.x. PMID: 12427098
Immune recognition of endometrial tumor antigens induced by multiparity.
Katsanis WA, Shields LB, Spinnato JA, Gerçel-Taylor C, Taylor DD
Gynecol Oncol 1998 Jul;70(1):33-9. doi: 10.1006/gyno.1998.4988. PMID: 9698470

Diagnosis

Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice.
Okano J, Kojima H, Katagi M, Nakagawa T, Nakae Y, Terashima T, Kurakane T, Kubota M, Maegawa H, Udagawa J
PLoS One 2016;11(11):e0166215. Epub 2016 Nov 15 doi: 10.1371/journal.pone.0166215. PMID: 27846299Free PMC Article
Early immunopathological diagnosis of ichthyosis with confetti in two sporadic cases with new mutations in keratin 10.
Diociaiuti A, Fortugno P, El Hachem M, Angelo C, Proto V, De Luca N, Martinelli D, Boldrini R, Castiglia D, Zambruno G
Acta Derm Venereol 2014 Sep;94(5):579-82. doi: 10.2340/00015555-1796. PMID: 24626314
Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model.
Mildner M, Jin J, Eckhart L, Kezic S, Gruber F, Barresi C, Stremnitzer C, Buchberger M, Mlitz V, Ballaun C, Sterniczky B, Födinger D, Tschachler E
J Invest Dermatol 2010 Sep;130(9):2286-94. Epub 2010 May 6 doi: 10.1038/jid.2010.115. PMID: 20445547
Immunohistochemical differentiation between inflammatory linear verrucous epidermal nevus (ILVEN) and psoriasis.
Vissers WH, Muys L, Erp PE, de Jong EM, van de Kerkhof PC
Eur J Dermatol 2004 Jul-Aug;14(4):216-20. PMID: 15319153

Therapy

Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice.
Okano J, Kojima H, Katagi M, Nakagawa T, Nakae Y, Terashima T, Kurakane T, Kubota M, Maegawa H, Udagawa J
PLoS One 2016;11(11):e0166215. Epub 2016 Nov 15 doi: 10.1371/journal.pone.0166215. PMID: 27846299Free PMC Article
Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model.
Mildner M, Jin J, Eckhart L, Kezic S, Gruber F, Barresi C, Stremnitzer C, Buchberger M, Mlitz V, Ballaun C, Sterniczky B, Födinger D, Tschachler E
J Invest Dermatol 2010 Sep;130(9):2286-94. Epub 2010 May 6 doi: 10.1038/jid.2010.115. PMID: 20445547
Topical treatment of mild to moderate plaque psoriasis with 0.3% tacrolimus gel and 0.5% tacrolimus cream: the effect on SUM score, epidermal proliferation, keratinization, T-cell subsets and HLA-DR expression.
Vissers WH, van Vlijmen I, van Erp PE, de Jong EM, van de Kerkhof PC
Br J Dermatol 2008 Apr;158(4):705-12. Epub 2008 Feb 16 doi: 10.1111/j.1365-2133.2008.08442.x. PMID: 18284400
Effects of topical treatment with budesonide on parameters for epidermal proliferation, keratinization and inflammation in psoriasis.
de Jong EM, Ferrier CM, de Zwart A, Wauben-Penris PJ, Korstanje C, van de Kerkhof PC
J Dermatol Sci 1995 May;9(3):185-94. doi: 10.1016/0923-1811(94)00376-p. PMID: 8664216

Prognosis

Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells?
Lacina L, Smetana K Jr, Dvoránková B, Stork J, Plzáková Z, Gabius HJ
J Dermatol Sci 2006 Nov;44(2):73-80. Epub 2006 Sep 26 doi: 10.1016/j.jdermsci.2006.08.008. PMID: 17000083
Effects of topical treatment with budesonide on parameters for epidermal proliferation, keratinization and inflammation in psoriasis.
de Jong EM, Ferrier CM, de Zwart A, Wauben-Penris PJ, Korstanje C, van de Kerkhof PC
J Dermatol Sci 1995 May;9(3):185-94. doi: 10.1016/0923-1811(94)00376-p. PMID: 8664216

Clinical prediction guides

CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders.
Arnold KA, Moran MC, Shi H, van Vlijmen-Willems IMJJ, Rodijk-Olthuis D, Smits JPH, Brewer MG
Exp Dermatol 2024 May;33(5):e15084. doi: 10.1111/exd.15084. PMID: 38711223
Hyaluronic acid-fibrin hydrogels show improved mechanical stability in dermo-epidermal skin substitutes.
Montero A, Atienza C, Elvira C, Jorcano JL, Velasco D
Mater Sci Eng C Mater Biol Appl 2021 Sep;128:112352. Epub 2021 Jul 31 doi: 10.1016/j.msec.2021.112352. PMID: 34474900
Effect of α-Lipoic Acid on the Development of Human Skin Equivalents Using a Pumpless Skin-on-a-Chip Model.
Kim K, Kim J, Kim H, Sung GY
Int J Mol Sci 2021 Feb 22;22(4) doi: 10.3390/ijms22042160. PMID: 33671528Free PMC Article
Topical treatment of mild to moderate plaque psoriasis with 0.3% tacrolimus gel and 0.5% tacrolimus cream: the effect on SUM score, epidermal proliferation, keratinization, T-cell subsets and HLA-DR expression.
Vissers WH, van Vlijmen I, van Erp PE, de Jong EM, van de Kerkhof PC
Br J Dermatol 2008 Apr;158(4):705-12. Epub 2008 Feb 16 doi: 10.1111/j.1365-2133.2008.08442.x. PMID: 18284400
Keratin expression in normal skin and epidermal neoplasms demonstrated by a panel of monoclonal antibodies.
Perkins W, Campbell I, Leigh IM, MacKie RM
J Cutan Pathol 1992 Dec;19(6):476-82. doi: 10.1111/j.1600-0560.1992.tb01600.x. PMID: 1283171

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