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Dermal immune complex deposition

MedGen UID:
1841613
•Concept ID:
C5826553
•
Finding
HPO: HP:0034643

Definition

Accumulation of antigen-bound antibody in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermal immune complex deposition

Professional guidelines

PubMed

Mesoglycan treatment restores defective fibrinolytic potential in cutaneous necrotizing venulitis.
Lotti T, Celasco G, Tsampau D, Teofoli P, Benci M, Dahm M, Comacchi C, Ghersetich I, Matucci-Cerinic M
Int J Dermatol 1993 May;32(5):368-71. doi: 10.1111/j.1365-4362.1993.tb01477.x. PMID: 8505166
Deposits of immunoglobulins and complement in skin of patients with rheumatoid arthritis. Influence of anti-rheumatic treatment.
Ullman S, Høier-Madsen M, Halberg P, Jans H, Sylvest J
Scand J Rheumatol 1979;8(2):119-23. doi: 10.3109/03009747909105349. PMID: 377474

Recent clinical studies

Etiology

Hardness and Painful Lesion of the Breast.
Vilas-Sueiro A, González-Vilas D, Aguilera C, Monteagudo B, De Las Heras C
Acta Dermatovenerol Croat 2017 Dec;25(4):305-306. PMID: 30064607
Elevated serum IgA anticardiolipin antibody levels in adult Henoch-Schönlein purpura.
Kawakami T, Watabe H, Mizoguchi M, Soma Y
Br J Dermatol 2006 Nov;155(5):983-7. doi: 10.1111/j.1365-2133.2006.07457.x. PMID: 17034529
Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease.
Alpsoy E, Uzun S, Akman A, Acar MA, Memişoglu HR, Başaran E
J Eur Acad Dermatol Venereol 2003 Sep;17(5):521-4. doi: 10.1046/j.1468-3083.2003.00625.x. PMID: 12941085
Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis.
Hall RP, Waldbauer GV
J Invest Dermatol 1988 May;90(5):658-63. doi: 10.1111/1523-1747.ep12560821. PMID: 3258898
Is Henoch-Schönlein purpura the systemic form of IgA nephropathy?
Waldo FB
Am J Kidney Dis 1988 Nov;12(5):373-7. doi: 10.1016/s0272-6386(88)80028-3. PMID: 3055961

Diagnosis

Hardness and Painful Lesion of the Breast.
Vilas-Sueiro A, González-Vilas D, Aguilera C, Monteagudo B, De Las Heras C
Acta Dermatovenerol Croat 2017 Dec;25(4):305-306. PMID: 30064607
Clinical features and diagnosis of epidermolysis bullosa acquisita.
Vorobyev A, Ludwig RJ, Schmidt E
Expert Rev Clin Immunol 2017 Feb;13(2):157-169. Epub 2016 Sep 8 doi: 10.1080/1744666X.2016.1221343. PMID: 27580464
Vesicular Contact Reaction May Progress into Erythema Multiforme.
Czarnecka-Operacz M, Jenerowicz D, Szulczyńska-Gabor J, Teresiak-Mikołajczak E, Szyfter-Harris J, Bowszyc-Dmochowska M
Acta Dermatovenerol Croat 2016 Dec;24(4):307-309. PMID: 28128086
Septic vasculitis and vasculopathy in some infectious emergencies: the perspective of the histopathologist.
Tomasini C
G Ital Dermatol Venereol 2015 Feb;150(1):73-85. Epub 2015 Jan 16 PMID: 25592669
Pityriasis lichenoides--an immune complex disease.
Clayton R, Haffenden G, Du Vivier A, Burton J, Mowbray J
Br J Dermatol 1977 Dec;97(6):629-34. doi: 10.1111/j.1365-2133.1977.tb14269.x. PMID: 146510

Therapy

Mesoglycan treatment restores defective fibrinolytic potential in cutaneous necrotizing venulitis.
Lotti T, Celasco G, Tsampau D, Teofoli P, Benci M, Dahm M, Comacchi C, Ghersetich I, Matucci-Cerinic M
Int J Dermatol 1993 May;32(5):368-71. doi: 10.1111/j.1365-4362.1993.tb01477.x. PMID: 8505166
Metal toxicity and the respiratory tract.
Nemery B
Eur Respir J 1990 Feb;3(2):202-19. PMID: 2178966
Idiopathic atrophie blanche.
Shornick JK, Nicholes BK, Bergstresser PR, Gilliam JN
J Am Acad Dermatol 1983 Jun;8(6):792-8. doi: 10.1016/s0190-9622(83)80008-5. PMID: 6345609
Propylthio-uracil-induced cutaneous vasculitis.
Gammeltoft M, Kristensen JK
Acta Derm Venereol 1982;62(2):171-3. PMID: 6179348
D-penicillamine and immune complex deposition.
Kirby JD, Dieppe PA, Huskisson EC, Smith B
Ann Rheum Dis 1979 Aug;38(4):344-6. doi: 10.1136/ard.38.4.344. PMID: 159020Free PMC Article

Prognosis

Hardness and Painful Lesion of the Breast.
Vilas-Sueiro A, González-Vilas D, Aguilera C, Monteagudo B, De Las Heras C
Acta Dermatovenerol Croat 2017 Dec;25(4):305-306. PMID: 30064607
Vesicular Contact Reaction May Progress into Erythema Multiforme.
Czarnecka-Operacz M, Jenerowicz D, Szulczyńska-Gabor J, Teresiak-Mikołajczak E, Szyfter-Harris J, Bowszyc-Dmochowska M
Acta Dermatovenerol Croat 2016 Dec;24(4):307-309. PMID: 28128086
Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease.
Alpsoy E, Uzun S, Akman A, Acar MA, Memişoglu HR, Başaran E
J Eur Acad Dermatol Venereol 2003 Sep;17(5):521-4. doi: 10.1046/j.1468-3083.2003.00625.x. PMID: 12941085
Immunological evaluation of erythema nodosum in tularaemia.
Akdiş AC, Kiliçturgay K, Helvaci S, Mistik R, Oral B
Br J Dermatol 1993 Sep;129(3):275-9. doi: 10.1111/j.1365-2133.1993.tb11846.x. PMID: 8286224
Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure.
Bielory L, Gascon P, Lawley TJ, Young NS, Frank MM
Medicine (Baltimore) 1988 Jan;67(1):40-57. PMID: 3257288

Clinical prediction guides

STAT6 gain-of-function variant exacerbates multiple allergic symptoms.
Takeuchi I, Yanagi K, Takada S, Uchiyama T, Igarashi A, Motomura K, Hayashi Y, Nagano N, Matsuoka R, Sugiyama H, Yoshioka T, Saito H, Kawai T, Miyaji Y, Inuzuka Y, Matsubara Y, Ohya Y, Shimizu T, Matsumoto K, Arai K, Nomura I, Kaname T, Morita H
J Allergy Clin Immunol 2023 May;151(5):1402-1409.e6. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.12.802. PMID: 36538978
Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
Emtenani S, Holtsche MM, Stahlkopf R, Seiler DL, Burn T, Liu H, Parker M, Yilmaz K, Dikmen HO, Lang MH, Sadik CD, Karsten CM, van Beek N, Ludwig RJ, Köhl J, Schmidt E
Front Immunol 2022;13:942493. Epub 2022 Nov 18 doi: 10.3389/fimmu.2022.942493. PMID: 36466856Free PMC Article
P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus.
González-Tajuelo R, Silván J, Pérez-Frías A, de la Fuente-Fernández M, Tejedor R, Espartero-Santos M, Vicente-Rabaneda E, Juarranz Á, Muñoz-Calleja C, Castañeda S, Gamallo C, Urzainqui A
Sci Rep 2017 Feb 2;7:41841. doi: 10.1038/srep41841. PMID: 28150814Free PMC Article
Metal toxicity and the respiratory tract.
Nemery B
Eur Respir J 1990 Feb;3(2):202-19. PMID: 2178966
Is Henoch-Schönlein purpura the systemic form of IgA nephropathy?
Waldo FB
Am J Kidney Dis 1988 Nov;12(5):373-7. doi: 10.1016/s0272-6386(88)80028-3. PMID: 3055961

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