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Reduced heme oxygenase activity

MedGen UID:
1841641
•Concept ID:
C5826608
•
Finding
HPO: HP:0034716

Definition

Activity of the enzyme heme oxygenase below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced heme oxygenase activity

Professional guidelines

PubMed

n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553
Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?
Voelkel NF, Bogaard HJ, Al Husseini A, Farkas L, Gomez-Arroyo J, Natarajan R
Antioxid Redox Signal 2013 May 10;18(14):1810-7. Epub 2012 Sep 28 doi: 10.1089/ars.2012.4828. PMID: 22870869
Heme oxygenase, a novel target for the treatment of hypertension and obesity?
Hosick PA, Stec DE
Am J Physiol Regul Integr Comp Physiol 2012 Jan 15;302(2):R207-14. Epub 2011 Nov 9 doi: 10.1152/ajpregu.00517.2011. PMID: 22071158Free PMC Article

Recent clinical studies

Etiology

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia.
Fu C, Wu Y, Liu S, Luo C, Lu Y, Liu M, Wang L, Zhang Y, Liu X
J Ethnopharmacol 2022 May 10;289:115021. Epub 2022 Jan 26 doi: 10.1016/j.jep.2022.115021. PMID: 35091012
Melatonin reduces OGD/R-induced neuron injury by regulating redox/inflammation/apoptosis signaling.
Zhi SM, Fang GX, Xie XM, Liu LH, Yan J, Liu DB, Yu HY
Eur Rev Med Pharmacol Sci 2020 Feb;24(3):1524-1536. doi: 10.26355/eurrev_202002_20211. PMID: 32096202
Implications of macrophage polarization in autoimmunity.
Funes SC, Rios M, Escobar-Vera J, Kalergis AM
Immunology 2018 Jun;154(2):186-195. Epub 2018 Mar 8 doi: 10.1111/imm.12910. PMID: 29455468Free PMC Article
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J
Cell Death Dis 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x. PMID: 29362432Free PMC Article
Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury.
Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW
J Hepatol 2017 Dec;67(6):1232-1242. Epub 2017 Aug 23 doi: 10.1016/j.jhep.2017.08.010. PMID: 28842295Free PMC Article

Diagnosis

d-Borneol enhances cisplatin sensitivity via autophagy dependent EMT signaling and NCOA4-mediated ferritinophagy.
Li J, Yuan J, Li Y, Wang J, Xie Q, Ma R, Wang J, Ren M, Lu D, Xu Z
Phytomedicine 2022 Nov;106:154411. Epub 2022 Aug 23 doi: 10.1016/j.phymed.2022.154411. PMID: 36030746
The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders (Review).
John OD, Mushunje AT, Surugau N, Guad RM
Int J Mol Med 2022 Sep;50(3) Epub 2022 Jul 29 doi: 10.3892/ijmm.2022.5176. PMID: 35904170Free PMC Article
Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications.
McClung JA, Levy L, Garcia V, Stec DE, Peterson SJ, Abraham NG
Pharmacol Ther 2022 Mar;231:107975. Epub 2021 Sep 6 doi: 10.1016/j.pharmthera.2021.107975. PMID: 34499923Free PMC Article
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553
Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.
Mendonça VR, Barral-Netto M
Mem Inst Oswaldo Cruz 2015 Dec;110(8):945-55. Epub 2015 Dec 11 doi: 10.1590/0074-02760150241. PMID: 26676319Free PMC Article

Therapy

PRMT1 driven PTX3 regulates ferritinophagy in glioma.
Lathoria K, Gowda P, Umdor SB, Patrick S, Suri V, Sen E
Autophagy 2023 Jul;19(7):1997-2014. Epub 2023 Jan 16 doi: 10.1080/15548627.2023.2165757. PMID: 36647288Free PMC Article
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Wang G, Wang Y, Yang Q, Xu C, Zheng Y, Wang L, Wu J, Zeng M, Luo M
Cell Death Dis 2022 Jan 10;13(1):29. doi: 10.1038/s41419-021-04478-x. PMID: 35013107Free PMC Article
Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells.
Tie F, Ding J, Hu N, Dong Q, Chen Z, Wang H
Int J Mol Sci 2021 Aug 17;22(16) doi: 10.3390/ijms22168847. PMID: 34445549Free PMC Article
A Novel Therapeutic Target, BACH1, Regulates Cancer Metabolism.
Padilla J, Lee J
Cells 2021 Mar 12;10(3) doi: 10.3390/cells10030634. PMID: 33809182Free PMC Article
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553

Prognosis

PRMT1 driven PTX3 regulates ferritinophagy in glioma.
Lathoria K, Gowda P, Umdor SB, Patrick S, Suri V, Sen E
Autophagy 2023 Jul;19(7):1997-2014. Epub 2023 Jan 16 doi: 10.1080/15548627.2023.2165757. PMID: 36647288Free PMC Article
d-Borneol enhances cisplatin sensitivity via autophagy dependent EMT signaling and NCOA4-mediated ferritinophagy.
Li J, Yuan J, Li Y, Wang J, Xie Q, Ma R, Wang J, Ren M, Lu D, Xu Z
Phytomedicine 2022 Nov;106:154411. Epub 2022 Aug 23 doi: 10.1016/j.phymed.2022.154411. PMID: 36030746
The therapeutic role of nutraceuticals targeting the Nrf2/HO-1 signaling pathway in liver cancer.
Alharbi KS, Almalki WH, Albratty M, Meraya AM, Najmi A, Vyas G, Singh SK, Dua K, Gupta G
J Food Biochem 2022 Oct;46(10):e14357. Epub 2022 Aug 9 doi: 10.1111/jfbc.14357. PMID: 35945911
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity.
Fallica AN, Sorrenti V, D'Amico AG, Salerno L, Romeo G, Intagliata S, Consoli V, Floresta G, Rescifina A, D'Agata V, Vanella L, Pittalà V
J Med Chem 2021 Sep 23;64(18):13373-13393. Epub 2021 Sep 2 doi: 10.1021/acs.jmedchem.1c00633. PMID: 34472337Free PMC Article
Haeme oxygenase signalling pathway: implications for cardiovascular disease.
Fredenburgh LE, Merz AA, Cheng S
Eur Heart J 2015 Jun 21;36(24):1512-8. Epub 2015 Mar 31 doi: 10.1093/eurheartj/ehv114. PMID: 25827602Free PMC Article

Clinical prediction guides

Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19.
de Lima F, Moraes CRP, Barbosa MS, Bombassaro B, Palma AC, Dertkigil SSJ, Moretti ML, Orsi FA, Annichino-Bizzacchi JM, Mansour E, Velloso LA, De Paula EV
Exp Biol Med (Maywood) 2023 Feb;248(4):309-316. Epub 2023 Feb 5 doi: 10.1177/15353702221139185. PMID: 36740756Free PMC Article
PRMT1 driven PTX3 regulates ferritinophagy in glioma.
Lathoria K, Gowda P, Umdor SB, Patrick S, Suri V, Sen E
Autophagy 2023 Jul;19(7):1997-2014. Epub 2023 Jan 16 doi: 10.1080/15548627.2023.2165757. PMID: 36647288Free PMC Article
Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia.
Fu C, Wu Y, Liu S, Luo C, Lu Y, Liu M, Wang L, Zhang Y, Liu X
J Ethnopharmacol 2022 May 10;289:115021. Epub 2022 Jan 26 doi: 10.1016/j.jep.2022.115021. PMID: 35091012
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Wang G, Wang Y, Yang Q, Xu C, Zheng Y, Wang L, Wu J, Zeng M, Luo M
Cell Death Dis 2022 Jan 10;13(1):29. doi: 10.1038/s41419-021-04478-x. PMID: 35013107Free PMC Article
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J
Cell Death Dis 2018 Jan 23;9(2):83. doi: 10.1038/s41419-017-0198-x. PMID: 29362432Free PMC Article

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