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Swollen achromatic neurons in the cerebral cortex

MedGen UID:
1841649
•Concept ID:
C5826609
•
Finding
Synonyms: Cerebral cortex Pick cells; Cerebral cortex swollen achromatic neurons
 
HPO: HP:0034717

Definition

The presence of enlarged and swollen neurons that lack Nissl bodies (the rough endoplasmic reticulum-achromasia refers to neurons that lack Nissl bodies) in the cortex of the brain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSwollen achromatic neurons in the cerebral cortex

Recent clinical studies

Etiology

A case of frontotemporal lobar degeneration with ubiquitin-positive intraneuronal inclusions.
Leel-Ossy L, Révész T, Almási K, Szucs I, Szabó E
Ideggyogy Sz 2007 Jul 30;60(7-8):330-5. PMID: 17713114

Diagnosis

A case of frontotemporal lobar degeneration with ubiquitin-positive intraneuronal inclusions.
Leel-Ossy L, Révész T, Almási K, Szucs I, Szabó E
Ideggyogy Sz 2007 Jul 30;60(7-8):330-5. PMID: 17713114
Quantification of the pathological changes in the temporal lobe of patients with a novel neurofilamentopathy: neurofilament inclusion disease (NID).
Cairns NJ, Armstrong RA
Clin Neuropathol 2004 May-Jun;23(3):107-12. PMID: 15200288
Corticobasal degeneration: an autopsy case clinically diagnosed as progressive supranuclear palsy.
Shiozawa M, Fukutani Y, Sasaki K, Isaki K, Hamano T, Hirayama M, Imamura K, Mukai M, Arai N, Cairns NJ
Clin Neuropathol 2000 Jul-Aug;19(4):192-9. PMID: 10919351
Focal cortical atrophy syndromes.
Black SE
Brain Cogn 1996 Jul;31(2):188-229. doi: 10.1006/brcg.1996.0042. PMID: 8811996
Cortical-basal ganglionic degeneration.
Riley DE, Lang AE, Lewis A, Resch L, Ashby P, Hornykiewicz O, Black S
Neurology 1990 Aug;40(8):1203-12. doi: 10.1212/wnl.40.8.1203. PMID: 2381527

Prognosis

Cortical-basal ganglionic degeneration.
Riley DE, Lang AE, Lewis A, Resch L, Ashby P, Hornykiewicz O, Black S
Neurology 1990 Aug;40(8):1203-12. doi: 10.1212/wnl.40.8.1203. PMID: 2381527

Clinical prediction guides

Corticobasal degeneration: an autopsy case clinically diagnosed as progressive supranuclear palsy.
Shiozawa M, Fukutani Y, Sasaki K, Isaki K, Hamano T, Hirayama M, Imamura K, Mukai M, Arai N, Cairns NJ
Clin Neuropathol 2000 Jul-Aug;19(4):192-9. PMID: 10919351
Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease.
Buée Scherrer V, Hof PR, Buée L, Leveugle B, Vermersch P, Perl DP, Olanow CW, Delacourte A
Acta Neuropathol 1996;91(4):351-9. doi: 10.1007/s004010050436. PMID: 8928611
Cortical-basal ganglionic degeneration.
Riley DE, Lang AE, Lewis A, Resch L, Ashby P, Hornykiewicz O, Black S
Neurology 1990 Aug;40(8):1203-12. doi: 10.1212/wnl.40.8.1203. PMID: 2381527

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