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Elevated circulating CA19-9 concentration

MedGen UID:
1841653
•Concept ID:
C5826515
•
Finding
Synonyms: Elevated circulating cancer antigen 19-9 concentration; Elevated circulating carbohydrate antigen 19-9 concentration; Elevated circulating sialylated Lewis a antigen concentration
 
HPO: HP:0034603

Definition

Concentration of CA19-9 above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating CA19-9 concentration

Professional guidelines

PubMed

Combined evaluation of some tumor associated antigens in the monitoring of integrated surgical and chemotherapeutic treatment of epithelial ovarian cancer.
Fioretti P, Gadducci A, Ferdeghini M, Bartolini T, Scatena P, Facchini V, Bianchi R
Eur J Gynaecol Oncol 1986;7(3):200-5. PMID: 3465535

Recent clinical studies

Etiology

Circulating natural antibodies against 3'-sialyllactose complement the diagnostic performance of CA19-9 for the early detection of pancreatic ductal adenocarcinoma.
Yamada K, Higashi K, Nagahori H, Saito K
Cancer Biomark 2020;27(1):121-128. doi: 10.3233/CBM-190158. PMID: 31771041
Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
Kim NH, Lee MY, Park JH, Park DI, Sohn CI, Choi K, Jung YS
Yonsei Med J 2017 Sep;58(5):918-924. doi: 10.3349/ymj.2017.58.5.918. PMID: 28792134Free PMC Article
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Jubran R, Kocsis J, Garam N, Maláti É, Gombos T, Barabás L, Gráf L, Prohászka Z, Fishelson Z
Int J Cancer 2017 Dec 1;141(11):2329-2335. Epub 2017 Aug 21 doi: 10.1002/ijc.30918. PMID: 28791678
Angiopoietin-2 and biliary diseases: elevated serum, but not bile levels are associated with cholangiocarcinoma.
Voigtländer T, David S, Thamm K, Schlué J, Metzger J, Manns MP, Lankisch TO
PLoS One 2014;9(5):e97046. Epub 2014 May 13 doi: 10.1371/journal.pone.0097046. PMID: 24823366Free PMC Article
Elevated carbohydrate antigen 19-9 (CA 19-9) in patients with Echinococcus infection.
Pfister M, Gottstein B, Kretschmer R, Cerny T, Cerny A
Clin Chem Lab Med 2001 Jun;39(6):527-30. doi: 10.1515/CCLM.2001.088. PMID: 11506466

Diagnosis

Nanoparticle-aided glycovariant assays to bridge biomarker performance and ctDNA results.
Gidwani K, Kekki H, Terävä J, Soukka T, Sundfeldt K, Pettersson K
Mol Aspects Med 2020 Apr;72:100831. Epub 2019 Nov 29 doi: 10.1016/j.mam.2019.11.001. PMID: 31787337
Circulating natural antibodies against 3'-sialyllactose complement the diagnostic performance of CA19-9 for the early detection of pancreatic ductal adenocarcinoma.
Yamada K, Higashi K, Nagahori H, Saito K
Cancer Biomark 2020;27(1):121-128. doi: 10.3233/CBM-190158. PMID: 31771041
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Angiopoietin-2 and biliary diseases: elevated serum, but not bile levels are associated with cholangiocarcinoma.
Voigtländer T, David S, Thamm K, Schlué J, Metzger J, Manns MP, Lankisch TO
PLoS One 2014;9(5):e97046. Epub 2014 May 13 doi: 10.1371/journal.pone.0097046. PMID: 24823366Free PMC Article
Elevated carbohydrate antigen 19-9 (CA 19-9) in patients with Echinococcus infection.
Pfister M, Gottstein B, Kretschmer R, Cerny T, Cerny A
Clin Chem Lab Med 2001 Jun;39(6):527-30. doi: 10.1515/CCLM.2001.088. PMID: 11506466

Therapy

A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: is an anti-VEGF strategy still applicable?
Ko AH, Dito E, Schillinger B, Venook AP, Xu Z, Bergsland EK, Wong D, Scott J, Hwang J, Tempero MA
Invest New Drugs 2008 Oct;26(5):463-71. Epub 2008 Apr 1 doi: 10.1007/s10637-008-9127-2. PMID: 18379729
Non-specific increase of serum carbohydrate antigen 19-9 in patients with liver disease associated with increased circulating levels of adhesion molecules.
Fabris C, Falleti E, Pirisi M, Soardo G, Toniutto P, Vitulli D, Bortolotti N, Gonano F, Bartoli E
Clin Chim Acta 1995 Dec 15;243(1):25-33. doi: 10.1016/0009-8981(95)06150-9. PMID: 8747511
Circulating tumor markers and assessment of response to intrahepatic chemotherapy of colon carcinoma.
Sears HF, Shen JW, Herlyn M, Atkinson B, Engstrom PF, Koprowski H
Am J Clin Oncol 1985 Apr;8(2):108-17. doi: 10.1097/00000421-198504000-00002. PMID: 2939709

Prognosis

Nanoparticle-aided glycovariant assays to bridge biomarker performance and ctDNA results.
Gidwani K, Kekki H, Terävä J, Soukka T, Sundfeldt K, Pettersson K
Mol Aspects Med 2020 Apr;72:100831. Epub 2019 Nov 29 doi: 10.1016/j.mam.2019.11.001. PMID: 31787337
Circulating natural antibodies against 3'-sialyllactose complement the diagnostic performance of CA19-9 for the early detection of pancreatic ductal adenocarcinoma.
Yamada K, Higashi K, Nagahori H, Saito K
Cancer Biomark 2020;27(1):121-128. doi: 10.3233/CBM-190158. PMID: 31771041
Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
Kim NH, Lee MY, Park JH, Park DI, Sohn CI, Choi K, Jung YS
Yonsei Med J 2017 Sep;58(5):918-924. doi: 10.3349/ymj.2017.58.5.918. PMID: 28792134Free PMC Article
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Jubran R, Kocsis J, Garam N, Maláti É, Gombos T, Barabás L, Gráf L, Prohászka Z, Fishelson Z
Int J Cancer 2017 Dec 1;141(11):2329-2335. Epub 2017 Aug 21 doi: 10.1002/ijc.30918. PMID: 28791678
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580

Clinical prediction guides

Nanoparticle-aided glycovariant assays to bridge biomarker performance and ctDNA results.
Gidwani K, Kekki H, Terävä J, Soukka T, Sundfeldt K, Pettersson K
Mol Aspects Med 2020 Apr;72:100831. Epub 2019 Nov 29 doi: 10.1016/j.mam.2019.11.001. PMID: 31787337
Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
Kim NH, Lee MY, Park JH, Park DI, Sohn CI, Choi K, Jung YS
Yonsei Med J 2017 Sep;58(5):918-924. doi: 10.3349/ymj.2017.58.5.918. PMID: 28792134Free PMC Article
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Jubran R, Kocsis J, Garam N, Maláti É, Gombos T, Barabás L, Gráf L, Prohászka Z, Fishelson Z
Int J Cancer 2017 Dec 1;141(11):2329-2335. Epub 2017 Aug 21 doi: 10.1002/ijc.30918. PMID: 28791678
Standardization of tumor markers - priorities identified through external quality assessment.
Sturgeon C
Scand J Clin Lab Invest Suppl 2016;245:S94-9. doi: 10.1080/00365513.2016.1210334. PMID: 27542005
Comparison of serum assays for TAG-72, CA19-9 and CEA in gastrointestinal carcinoma patients.
Ohuchi N, Takahashi K, Matoba N, Sato T, Taira Y, Sakai N, Masuda M, Mori S
Jpn J Clin Oncol 1989 Sep;19(3):242-8. PMID: 2810823

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