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Decreased urinary uromodulin level

MedGen UID:
1841670
•Concept ID:
C5826736
•
Finding
Synonym: Uromodulin low in urine
 
HPO: HP:0034886

Definition

The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for urine concentration, is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urinary uromodulin level

Recent clinical studies

Etiology

Decreased preoperative urinary uromodulin as a predictor of acute kidney injury and perioperative kidney dysfunction in patients undergoing cardiac surgery: A prospective cohort study.
Zhang H, Lang H, Ma M, Yu M, Chai H, Hu Y, Chen W, Chen X
Clin Chim Acta 2022 May 1;530:1-7. Epub 2022 Feb 15 doi: 10.1016/j.cca.2022.02.008. PMID: 35176269
Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease.
Ponte B, Sadler MC, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, Hayward C, Kutalik Z, Devuyst O
Kidney Int 2021 Dec;100(6):1282-1291. Epub 2021 Oct 9 doi: 10.1016/j.kint.2021.08.032. PMID: 34634361
Study of the relationship between urinary level of uromodulin, renal involvement and disease activity in patients with systemic lupus erythrematosus.
Bedair RN, Amin Ismail MM, Gaber EW, Kader Mahmoud RA, Mowafy MN
Saudi J Kidney Dis Transpl 2020 Jan-Feb;31(1):32-43. doi: 10.4103/1319-2442.279959. PMID: 32129195
Assessment of Cross-correlations Between Selected Macromolecules in Urine of Children with Idiopathic Hypercalciuria.
Jobs K, Jung A, Lewicki S, Murawski P, Pączek L, Zdanowski R
Urol J 2018 Sep 26;15(5):231-237. doi: 10.22037/uj.v0i0.3956. PMID: 29353465
The serum uromodulin level is associated with kidney function.
Risch L, Lhotta K, Meier D, Medina-Escobar P, Nydegger UE, Risch M
Clin Chem Lab Med 2014 Dec;52(12):1755-61. doi: 10.1515/cclm-2014-0505. PMID: 24933630

Diagnosis

Decreased preoperative urinary uromodulin as a predictor of acute kidney injury and perioperative kidney dysfunction in patients undergoing cardiac surgery: A prospective cohort study.
Zhang H, Lang H, Ma M, Yu M, Chai H, Hu Y, Chen W, Chen X
Clin Chim Acta 2022 May 1;530:1-7. Epub 2022 Feb 15 doi: 10.1016/j.cca.2022.02.008. PMID: 35176269
Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease.
Ponte B, Sadler MC, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, Hayward C, Kutalik Z, Devuyst O
Kidney Int 2021 Dec;100(6):1282-1291. Epub 2021 Oct 9 doi: 10.1016/j.kint.2021.08.032. PMID: 34634361
Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions.
Du MF, Yao S, Zou T, Mu JJ, Zhang XY, Hu GL, Chu C, Jia H, Liao YY, Chen C, Wang D, Ma Q, Yan Y, Wang KK, Sun Y, Niu ZJ, Yan RC, Zhang X, Zhou HW, Gao WH, Li H, Li CH, Gao K, Zhang J, Yang TL, Wang Y
J Clin Hypertens (Greenwich) 2021 Oct;23(10):1897-1906. Epub 2021 Aug 7 doi: 10.1111/jch.14347. PMID: 34363725Free PMC Article
Study of the relationship between urinary level of uromodulin, renal involvement and disease activity in patients with systemic lupus erythrematosus.
Bedair RN, Amin Ismail MM, Gaber EW, Kader Mahmoud RA, Mowafy MN
Saudi J Kidney Dis Transpl 2020 Jan-Feb;31(1):32-43. doi: 10.4103/1319-2442.279959. PMID: 32129195
Renal function and novel urinary biomarkers in infants with neonatal encephalopathy.
Sweetman DU, Onwuneme C, Watson WR, O'Neill A, Murphy JF, Molloy EJ
Acta Paediatr 2016 Nov;105(11):e513-e519. doi: 10.1111/apa.13555. PMID: 27551944

Therapy

Decreased preoperative urinary uromodulin as a predictor of acute kidney injury and perioperative kidney dysfunction in patients undergoing cardiac surgery: A prospective cohort study.
Zhang H, Lang H, Ma M, Yu M, Chai H, Hu Y, Chen W, Chen X
Clin Chim Acta 2022 May 1;530:1-7. Epub 2022 Feb 15 doi: 10.1016/j.cca.2022.02.008. PMID: 35176269
Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease.
Ponte B, Sadler MC, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, Hayward C, Kutalik Z, Devuyst O
Kidney Int 2021 Dec;100(6):1282-1291. Epub 2021 Oct 9 doi: 10.1016/j.kint.2021.08.032. PMID: 34634361
Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions.
Du MF, Yao S, Zou T, Mu JJ, Zhang XY, Hu GL, Chu C, Jia H, Liao YY, Chen C, Wang D, Ma Q, Yan Y, Wang KK, Sun Y, Niu ZJ, Yan RC, Zhang X, Zhou HW, Gao WH, Li H, Li CH, Gao K, Zhang J, Yang TL, Wang Y
J Clin Hypertens (Greenwich) 2021 Oct;23(10):1897-1906. Epub 2021 Aug 7 doi: 10.1111/jch.14347. PMID: 34363725Free PMC Article
Uromodulin and microRNAs in Kidney Transplantation-Association with Kidney Graft Function.
Borštnar Š, Večerić-Haler Ž, Boštjančič E, Pipan Tkalec Ž, Kovač D, Lindič J, Kojc N
Int J Mol Sci 2020 Aug 5;21(16) doi: 10.3390/ijms21165592. PMID: 32764335Free PMC Article
Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study.
Zhang WR, Craven TE, Malhotra R, Cheung AK, Chonchol M, Drawz P, Sarnak MJ, Parikh CR, Shlipak MG, Ix JH; SPRINT Research Group
Ann Intern Med 2018 Nov 6;169(9):610-618. Epub 2018 Oct 23 doi: 10.7326/M18-1037. PMID: 30357395Free PMC Article

Prognosis

Decreased preoperative urinary uromodulin as a predictor of acute kidney injury and perioperative kidney dysfunction in patients undergoing cardiac surgery: A prospective cohort study.
Zhang H, Lang H, Ma M, Yu M, Chai H, Hu Y, Chen W, Chen X
Clin Chim Acta 2022 May 1;530:1-7. Epub 2022 Feb 15 doi: 10.1016/j.cca.2022.02.008. PMID: 35176269
Uromodulin and microRNAs in Kidney Transplantation-Association with Kidney Graft Function.
Borštnar Š, Večerić-Haler Ž, Boštjančič E, Pipan Tkalec Ž, Kovač D, Lindič J, Kojc N
Int J Mol Sci 2020 Aug 5;21(16) doi: 10.3390/ijms21165592. PMID: 32764335Free PMC Article
A study of urinary Tamm-Horsfall protein excretion in adult type 2 diabetes mellitus
.
Zheng M, Ye S, Chen Y, Chen M
Clin Nephrol 2018 Jul;90(1):40-45. doi: 10.5414/CN109220. PMID: 29393842
Assessment of Cross-correlations Between Selected Macromolecules in Urine of Children with Idiopathic Hypercalciuria.
Jobs K, Jung A, Lewicki S, Murawski P, Pączek L, Zdanowski R
Urol J 2018 Sep 26;15(5):231-237. doi: 10.22037/uj.v0i0.3956. PMID: 29353465
Renal function and novel urinary biomarkers in infants with neonatal encephalopathy.
Sweetman DU, Onwuneme C, Watson WR, O'Neill A, Murphy JF, Molloy EJ
Acta Paediatr 2016 Nov;105(11):e513-e519. doi: 10.1111/apa.13555. PMID: 27551944

Clinical prediction guides

Decreased preoperative urinary uromodulin as a predictor of acute kidney injury and perioperative kidney dysfunction in patients undergoing cardiac surgery: A prospective cohort study.
Zhang H, Lang H, Ma M, Yu M, Chai H, Hu Y, Chen W, Chen X
Clin Chim Acta 2022 May 1;530:1-7. Epub 2022 Feb 15 doi: 10.1016/j.cca.2022.02.008. PMID: 35176269
Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease.
Ponte B, Sadler MC, Olinger E, Vollenweider P, Bochud M, Padmanabhan S, Hayward C, Kutalik Z, Devuyst O
Kidney Int 2021 Dec;100(6):1282-1291. Epub 2021 Oct 9 doi: 10.1016/j.kint.2021.08.032. PMID: 34634361
Uromodulin and microRNAs in Kidney Transplantation-Association with Kidney Graft Function.
Borštnar Š, Večerić-Haler Ž, Boštjančič E, Pipan Tkalec Ž, Kovač D, Lindič J, Kojc N
Int J Mol Sci 2020 Aug 5;21(16) doi: 10.3390/ijms21165592. PMID: 32764335Free PMC Article
Study of the relationship between urinary level of uromodulin, renal involvement and disease activity in patients with systemic lupus erythrematosus.
Bedair RN, Amin Ismail MM, Gaber EW, Kader Mahmoud RA, Mowafy MN
Saudi J Kidney Dis Transpl 2020 Jan-Feb;31(1):32-43. doi: 10.4103/1319-2442.279959. PMID: 32129195
Assessment of Cross-correlations Between Selected Macromolecules in Urine of Children with Idiopathic Hypercalciuria.
Jobs K, Jung A, Lewicki S, Murawski P, Pączek L, Zdanowski R
Urol J 2018 Sep 26;15(5):231-237. doi: 10.22037/uj.v0i0.3956. PMID: 29353465

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