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Bone marrow xanthomatosis

MedGen UID:
1841688
•Concept ID:
C5826537
•
Disease or Syndrome
Synonym: Bone marrow xanthomas
 
HPO: HP:0034627

Definition

Lipid deposits localized within the bone marrow. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow xanthomatosis

Recent clinical studies

Etiology

Oral verruciform xanthoma in chronic graft-versus-host disease patients.
Bar O, Elad S, Avni B, Abu-Tair J, Zaharia B, Hanut A, Zadik Y
Support Care Cancer 2021 Jan;29(1):79-84. Epub 2020 Aug 15 doi: 10.1007/s00520-020-05681-w. PMID: 32803727
Late effects of childhood cancer treatment: severe hypertriglyceridaemia, central obesity, non alcoholic fatty liver disease and diabetes as complications of childhood total body irradiation.
Rajendran R, Abu E, Fadl A, Byrne CD
Diabet Med 2013 Aug;30(8):e239-42. doi: 10.1111/dme.12234. PMID: 23692373
Xanthoma disseminatum in a child with cranial bone involvement.
Yağci B, Varan A, Altinok G, Söylemezoğlu F, Cila A, Büyükpamukçu M
J Pediatr Hematol Oncol 2008 Apr;30(4):310-2. doi: 10.1097/MPH.0b013e31815f88f2. PMID: 18391701

Diagnosis

Oral verruciform xanthoma in chronic graft-versus-host disease patients.
Bar O, Elad S, Avni B, Abu-Tair J, Zaharia B, Hanut A, Zadik Y
Support Care Cancer 2021 Jan;29(1):79-84. Epub 2020 Aug 15 doi: 10.1007/s00520-020-05681-w. PMID: 32803727
Necrobiotic Xanthogranuloma.
Dellatorre G, Miqueloto JK
JAMA Dermatol 2020 Jun 1;156(6):696. doi: 10.1001/jamadermatol.2020.0897. PMID: 32374351
Necrobiotic xanthogranuloma.
Jaén-Águila F, Vargas-Hitos JA, Jiménez-Alonso J
QJM 2014 Oct;107(10):859. Epub 2014 Mar 22 doi: 10.1093/qjmed/hcu066. PMID: 24659748
Necrobiotic xanthogranuloma.
Spicknall KE, Mehregan DA
Int J Dermatol 2009 Jan;48(1):1-10. doi: 10.1111/j.1365-4632.2009.03912.x. PMID: 19126043
Necrobiotic xanthogranuloma.
Mehregan DA, Winkelmann RK
Arch Dermatol 1992 Jan;128(1):94-100. PMID: 1739294

Therapy

Necrobiotic xanthogranuloma in IgG-κ multiple myeloma.
Giacalone S, Genovese G, Benzecry V, Berti E, Cusini M
Br J Haematol 2021 Apr;193(2):211. Epub 2021 Feb 2 doi: 10.1111/bjh.17300. PMID: 33529369
Necrobiotic Xanthogranuloma.
Dellatorre G, Miqueloto JK
JAMA Dermatol 2020 Jun 1;156(6):696. doi: 10.1001/jamadermatol.2020.0897. PMID: 32374351
Necrobiotic xanthogranuloma.
Jaén-Águila F, Vargas-Hitos JA, Jiménez-Alonso J
QJM 2014 Oct;107(10):859. Epub 2014 Mar 22 doi: 10.1093/qjmed/hcu066. PMID: 24659748
Hyperlipidemic myeloma: review of 53 cases.
Misselwitz B, Goede JS, Pestalozzi BC, Schanz U, Seebach JD
Ann Hematol 2010 Jun;89(6):569-77. Epub 2009 Nov 17 doi: 10.1007/s00277-009-0849-9. PMID: 19921193
Necrobiotic xanthogranuloma with paraproteinemia.
Kossard S, Winkelmann RK
J Am Acad Dermatol 1980 Sep;3(3):257-70. doi: 10.1016/s0190-9622(80)80189-7. PMID: 7451693

Prognosis

Xanthoma-like Skin Changes in an Elderly Woman with a Normal Lipid Profile.
Nockowski P, Woźniak Z, Reich A, Maj J
Acta Dermatovenerol Croat 2017 Jul;25(2):167-169. PMID: 28871936
Nodular and bullous cutaneous mastocytosis of the xanthelasmoid type: case report.
Husak R, Blume-Peytavi U, Pfrommer C, Geilen CC, Goerdt S, Orfanos CE
Br J Dermatol 2001 Feb;144(2):355-8. doi: 10.1046/j.1365-2133.2001.04026.x. PMID: 11251572
Necrobiotic xanthogranuloma.
Mehregan DA, Winkelmann RK
Arch Dermatol 1992 Jan;128(1):94-100. PMID: 1739294
Autoimmune hyperlipidemia in a patient. Atherosclerotic course and chaning immunoglobulin pattern during 21 years of study.
Lewis LA, deWolfe VD, Butkus A, Page IH
Am J Med 1975 Aug;59(2):208-18. doi: 10.1016/0002-9343(75)90355-1. PMID: 168771
Letterer-Siwe disease. A survey and a review of the course in two subchronic cases.
Nyholm K, Reed G, Sjolin KE
Acta Pathol Microbiol Scand 1967;70(4):481-500. PMID: 5582374

Clinical prediction guides

Xanthoma-like Skin Changes in an Elderly Woman with a Normal Lipid Profile.
Nockowski P, Woźniak Z, Reich A, Maj J
Acta Dermatovenerol Croat 2017 Jul;25(2):167-169. PMID: 28871936
Characterization of a novel variant of apolipoprotein E, E2 Fukuoka (Arg-224 --> Gln) in a hyperlipidemic patient with xanthomatosis.
Moriyama K, Sasaki J, Takada Y, Arakawa F, Matsunaga A, Ito Y, Arakawa K
Biochim Biophys Acta 1996 Jun 11;1301(3):185-90. doi: 10.1016/0005-2760(96)00014-8. PMID: 8664327
Periorbital necrobiotic xanthogranuloma and stage I multiple myeloma. Ultrastructure and response to pulsed dexamethasone documented by magnetic resonance imaging.
Plotnick H, Taniguchi Y, Hashimoto K, Negendank W, Tranchida L
J Am Acad Dermatol 1991 Aug;25(2 Pt 2):373-7. doi: 10.1016/0190-9622(91)70208-j. PMID: 1894775
Multifocal verruciform xanthoma of the upper aerodigestive tract in a child with a systemic lipid storage disease.
Travis WD, Davis GE, Tsokos M, Lebovics R, Merrick HF, Miller SP, Gregg RE, Di Bisceglie AM, Parker RI, Ishak KG
Am J Surg Pathol 1989 Apr;13(4):309-16. doi: 10.1097/00000478-198904000-00006. PMID: 2539022
Intraosseous xanthoma associated with hyperlipoproteinemia. A case report.
Inserra S, Einhorn TA, Vigorita VJ, Smith AG
Clin Orthop Relat Res 1984 Jul-Aug;(187):218-22. PMID: 6744721

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