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Decreased stool elastase level

MedGen UID:
1841697
•Concept ID:
C5826415
•
Finding
Synonym: Elastase low in stool
 
HPO: HP:0034469

Definition

Reduced amount of pancreatic elastase in the stool. This feature may be observed with pancreatic insufficiency. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased stool elastase level

Professional guidelines

PubMed

Vitamin D3 in patients with various grades of chronic pancreatitis, according to morphological and functional criteria of the pancreas.
Mann ST, Stracke H, Lange U, Klör HU, Teichmann J
Dig Dis Sci 2003 Mar;48(3):533-8. doi: 10.1023/a:1022540816990. PMID: 12757166
Elevated fecal levels of endogenous pancreatic endopeptidases after antibiotic treatment.
Borgström A, Genell S, Ohlsson K
Scand J Gastroenterol 1977;12(5):525-9. doi: 10.3109/00365527709181329. PMID: 918546

Recent clinical studies

Etiology

Atrophy of remnant pancreas after pancreatoduodenectomy: Risk factors and effects on quality of life, nutritional status, and pancreatic function.
Jung W, Kim H, Kwon W, Jang JY
J Hepatobiliary Pancreat Sci 2022 Feb;29(2):239-249. Epub 2021 Apr 15 doi: 10.1002/jhbp.949. PMID: 33773065
Effects of pancreatectomy on nutritional state, pancreatic function, and quality of life over 5 years of follow up.
Shin YC, Han Y, Kim E, Kwon W, Kim H, Jang JY
J Hepatobiliary Pancreat Sci 2022 Nov;29(11):1175-1184. Epub 2021 Jan 4 doi: 10.1002/jhbp.861. PMID: 33175467
Evaluation of pancreatic exocrine functions in rheumatoid arthritis.
Sisman P, Yucel E
Bratisl Lek Listy 2018;119(8):494-497. doi: 10.4149/BLL_2018_090. PMID: 30160157
The effect of primary hyperparathyroidism on pancreatic exocrine function.
Sisman P, Avci M, Akkurt A, Sahin AB, Gul OO, Ersoy C, Erturk E
J Endocrinol Invest 2018 Mar;41(3):293-298. Epub 2017 Aug 2 doi: 10.1007/s40618-017-0727-6. PMID: 28770447
Nutritional status, fecal elastase-1, and 13C-labeled mixed triglyceride breath test in the long-term after pancreaticoduodenectomy.
Muniz CK, dos Santos JS, Pfrimer K, Ferrioli E, Kemp R, Marchini JS, Cunha SF
Pancreas 2014 Apr;43(3):445-50. doi: 10.1097/MPA.0000000000000048. PMID: 24622077

Diagnosis

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.
Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H
Pediatr Diabetes 2018 May;19(3):398-402. Epub 2017 Oct 17 doi: 10.1111/pedi.12592. PMID: 29044779
Fecal Calprotectin, Elastase, and Alpha-1-Antitrypsin Levels After Roux-en-Y Gastric Bypass; Calprotectin Is Significantly Elevated in the Majority of Patients.
Boerlage TC, Westerink F, Poland DC, Huibregtse IL, Acherman YI, Gerdes VE
Obes Surg 2016 Dec;26(12):2974-2980. doi: 10.1007/s11695-016-2222-0. PMID: 27216731Free PMC Article
Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients.
Özcan M, Öztürk GZ, Köse M, Emet S, Aydın Ş, Arslan K, Arman Y, Akkaya V, Tükek T
Turk Kardiyol Dern Ars 2015 Mar;43(2):131-7. doi: 10.5543/tkda.2015.06606. PMID: 25782117
Exocrine pancreas disfunction in severely traumatised patients and early enteral nutrition.
Senkal M, Ceylan B, Deska T, Marpe B, Geier B
Ulus Travma Acil Cerrahi Derg 2008 Jan;14(1):34-9. PMID: 18306065
Faecal elastase-1: lyophilization of stool samples prevents false low results in diarrhoea.
Fischer B, Hoh S, Wehler M, Hahn EG, Schneider HT
Scand J Gastroenterol 2001 Jul;36(7):771-4. doi: 10.1080/003655201300192058. PMID: 11444478

Therapy

Atrophy of remnant pancreas after pancreatoduodenectomy: Risk factors and effects on quality of life, nutritional status, and pancreatic function.
Jung W, Kim H, Kwon W, Jang JY
J Hepatobiliary Pancreat Sci 2022 Feb;29(2):239-249. Epub 2021 Apr 15 doi: 10.1002/jhbp.949. PMID: 33773065
Effects of pancreatectomy on nutritional state, pancreatic function, and quality of life over 5 years of follow up.
Shin YC, Han Y, Kim E, Kwon W, Kim H, Jang JY
J Hepatobiliary Pancreat Sci 2022 Nov;29(11):1175-1184. Epub 2021 Jan 4 doi: 10.1002/jhbp.861. PMID: 33175467
Exocrine pancreatic insufficiency after esophagectomy: a systematic review of literature.
Blonk L, Wierdsma NJ, Jansma EP, Kazemier G, van der Peet DL, Straatman J
Dis Esophagus 2021 Dec 24;34(12) doi: 10.1093/dote/doab003. PMID: 33558869
Evaluation of pancreatic exocrine functions in rheumatoid arthritis.
Sisman P, Yucel E
Bratisl Lek Listy 2018;119(8):494-497. doi: 10.4149/BLL_2018_090. PMID: 30160157
Serum MMPs 7-9 and their inhibitors during glucocorticoid and anti-TNF-α therapy in pediatric inflammatory bowel disease.
Mäkitalo L, Rintamäki H, Tervahartiala T, Sorsa T, Kolho KL
Scand J Gastroenterol 2012 Jul;47(7):785-94. Epub 2012 Apr 23 doi: 10.3109/00365521.2012.677954. PMID: 22519363

Prognosis

Effects of pancreatectomy on nutritional state, pancreatic function, and quality of life over 5 years of follow up.
Shin YC, Han Y, Kim E, Kwon W, Kim H, Jang JY
J Hepatobiliary Pancreat Sci 2022 Nov;29(11):1175-1184. Epub 2021 Jan 4 doi: 10.1002/jhbp.861. PMID: 33175467
Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.
Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H
Pediatr Diabetes 2018 May;19(3):398-402. Epub 2017 Oct 17 doi: 10.1111/pedi.12592. PMID: 29044779
The effect of primary hyperparathyroidism on pancreatic exocrine function.
Sisman P, Avci M, Akkurt A, Sahin AB, Gul OO, Ersoy C, Erturk E
J Endocrinol Invest 2018 Mar;41(3):293-298. Epub 2017 Aug 2 doi: 10.1007/s40618-017-0727-6. PMID: 28770447
Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy.
Pai CG, Kamath MG, Shetty MV, Kurien A
World J Gastroenterol 2017 May 21;23(19):3538-3545. doi: 10.3748/wjg.v23.i19.3538. PMID: 28596690Free PMC Article
Exocrine pancreas disfunction in severely traumatised patients and early enteral nutrition.
Senkal M, Ceylan B, Deska T, Marpe B, Geier B
Ulus Travma Acil Cerrahi Derg 2008 Jan;14(1):34-9. PMID: 18306065

Clinical prediction guides

Atrophy of remnant pancreas after pancreatoduodenectomy: Risk factors and effects on quality of life, nutritional status, and pancreatic function.
Jung W, Kim H, Kwon W, Jang JY
J Hepatobiliary Pancreat Sci 2022 Feb;29(2):239-249. Epub 2021 Apr 15 doi: 10.1002/jhbp.949. PMID: 33773065
Effects of pancreatectomy on nutritional state, pancreatic function, and quality of life over 5 years of follow up.
Shin YC, Han Y, Kim E, Kwon W, Kim H, Jang JY
J Hepatobiliary Pancreat Sci 2022 Nov;29(11):1175-1184. Epub 2021 Jan 4 doi: 10.1002/jhbp.861. PMID: 33175467
Exocrine pancreatic insufficiency after esophagectomy: a systematic review of literature.
Blonk L, Wierdsma NJ, Jansma EP, Kazemier G, van der Peet DL, Straatman J
Dis Esophagus 2021 Dec 24;34(12) doi: 10.1093/dote/doab003. PMID: 33558869
Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.
Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H
Pediatr Diabetes 2018 May;19(3):398-402. Epub 2017 Oct 17 doi: 10.1111/pedi.12592. PMID: 29044779
Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients.
Özcan M, Öztürk GZ, Köse M, Emet S, Aydın Ş, Arslan K, Arman Y, Akkaya V, Tükek T
Turk Kardiyol Dern Ars 2015 Mar;43(2):131-7. doi: 10.5543/tkda.2015.06606. PMID: 25782117

Recent systematic reviews

Exocrine pancreatic insufficiency after esophagectomy: a systematic review of literature.
Blonk L, Wierdsma NJ, Jansma EP, Kazemier G, van der Peet DL, Straatman J
Dis Esophagus 2021 Dec 24;34(12) doi: 10.1093/dote/doab003. PMID: 33558869

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