U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reduced sulfide:quinone oxidoreductase activity

MedGen UID:
1841699
•Concept ID:
C5826475
•
Finding
HPO: HP:0034555

Definition

Reduced activity of the enzyme sulfide:quinone oxidoreductase, which typically is measured in a biopsy specimen from liver or muscle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced sulfide:quinone oxidoreductase activity

Recent clinical studies

Etiology

Rhodaneses minimize the accumulation of cellular sulfane sulfur to avoid disulfide stress during sulfide oxidation in bacteria.
Ran M, Li Q, Xin Y, Ma S, Zhao R, Wang M, Xun L, Xia Y
Redox Biol 2022 Jul;53:102345. Epub 2022 May 26 doi: 10.1016/j.redox.2022.102345. PMID: 35653932Free PMC Article
Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase.
Baugh SDP, Jackson MR, Rashad AA, Reitz AB, Lam PYS, Jorns MS
Bioorg Med Chem Lett 2021 Dec 15;54:128443. Epub 2021 Nov 9 doi: 10.1016/j.bmcl.2021.128443. PMID: 34763081Free PMC Article
Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease.
Friederich MW, Elias AF, Kuster A, Laugwitz L, Larson AA, Landry AP, Ellwood-Digel L, Mirsky DM, Dimmock D, Haven J, Jiang H, MacLean KN, Styren K, Schoof J, Goujon L, Lefrancois T, Friederich M, Coughlin CR 2nd, Banerjee R, Haack TB, Van Hove JLK
J Inherit Metab Dis 2020 Sep;43(5):1024-1036. Epub 2020 Apr 15 doi: 10.1002/jimd.12232. PMID: 32160317Free PMC Article
S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO.
Lu C, Kavalier A, Lukyanov E, Gross SS
Methods 2013 Aug 1;62(2):177-81. Epub 2013 Jun 27 doi: 10.1016/j.ymeth.2013.05.020. PMID: 23811297Free PMC Article
Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology.
Bełtowski J, Jamroz-Wiśniewska A
Antioxid Redox Signal 2012 Jul 1;17(1):81-94. Epub 2011 Dec 19 doi: 10.1089/ars.2011.4358. PMID: 22034938Free PMC Article

Therapy

Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure.
Jackson MR, Cox KD, Baugh SDP, Wakeen L, Rashad AA, Lam PYS, Polyak B, Jorns MS
Cardiovasc Res 2022 Jun 22;118(7):1771-1784. doi: 10.1093/cvr/cvab206. PMID: 34132787Free PMC Article
Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology.
Bełtowski J, Jamroz-Wiśniewska A
Antioxid Redox Signal 2012 Jul 1;17(1):81-94. Epub 2011 Dec 19 doi: 10.1089/ars.2011.4358. PMID: 22034938Free PMC Article

Clinical prediction guides

Transient Kinetic Analysis of Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase.
Mishanina TV, Yadav PK, Ballou DP, Banerjee R
J Biol Chem 2015 Oct 9;290(41):25072-80. Epub 2015 Aug 28 doi: 10.1074/jbc.M115.682369. PMID: 26318450Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...