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Bone marrow vacuolated lymphocytes

MedGen UID:
1841708
•Concept ID:
C5826426
•
Finding
Synonym: Bone marrow: vacuolated lymphocytes
 
HPO: HP:0034483

Definition

The presence of lymphocytes with multilple vacuoles (a membrane-bound cell organelle) in the bone marrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow vacuolated lymphocytes

Professional guidelines

PubMed

A reappraisal of the histopathologic criteria for the diagnosis of cutaneous allogeneic acute graft-vs-host disease.
Massi D, Franchi A, Pimpinelli N, Laszlo D, Bosi A, Santucci M
Am J Clin Pathol 1999 Dec;112(6):791-800. PMID: 10587702

Recent clinical studies

Etiology

Optimization of adipose tissue-derived mesenchymal stem cells by rapamycin in a murine model of acute graft-versus-host disease.
Kim KW, Moon SJ, Park MJ, Kim BM, Kim EK, Lee SH, Lee EJ, Chung BH, Yang CW, Cho ML
Stem Cell Res Ther 2015 Oct 23;6:202. doi: 10.1186/s13287-015-0197-8. PMID: 26497134Free PMC Article
The pathologic findings of skin, lymph node, liver, and bone marrow in patients with adult-onset still disease: a comprehensive analysis of 40 cases.
Kim HA, Kwon JE, Yim H, Suh CH, Jung JY, Han JH
Medicine (Baltimore) 2015 May;94(17):e787. doi: 10.1097/MD.0000000000000787. PMID: 25929927Free PMC Article
The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses.
Reyes García MG, García Tamayo F
Biomed Res Int 2013;2013:352414. Epub 2012 Dec 26 doi: 10.1155/2013/352414. PMID: 23509712Free PMC Article
Peripheral blood and bone marrow changes in patients with acquired immunodeficiency syndrome.
Adediran IA, Durosinmi MA
Afr J Med Med Sci 2006 Dec;35 Suppl:85-91. PMID: 18050779
Hematologic abnormalities in the acquired immune deficiency syndrome.
Spivak JL, Bender BS, Quinn TC
Am J Med 1984 Aug;77(2):224-8. doi: 10.1016/0002-9343(84)90695-8. PMID: 6465173

Diagnosis

Haemophagocytosis and atypical vacuolated lymphocytes in bone marrow and blood films after SARS-CoV-2 vaccination.
Sassi M, Khefacha L, Merzigui R, Rakez R, Boukhriss S, Laatiri MA
Br J Haematol 2021 Dec;195(5):649. Epub 2021 Jul 27 doi: 10.1111/bjh.17660. PMID: 34312842Free PMC Article
18F-FDG PET/CT in Xanthoma Disseminatum.
Arslan E, Aksoy T, Leblebici C, Koku-Aksu AE, Çermik TF
Clin Nucl Med 2020 Sep;45(9):681-682. doi: 10.1097/RLU.0000000000003181. PMID: 32657869
Atypical blood and bone marrow lymphocytes in ALK-positive anaplastic T-cell lymphoma: important lessons.
Mahdi AJ, Elmusharaf N, Osman H, Thompson I
BMJ Case Rep 2013 Sep 13;2013 doi: 10.1136/bcr-2013-200982. PMID: 24038295Free PMC Article
Peripheral blood and bone marrow changes in patients with acquired immunodeficiency syndrome.
Adediran IA, Durosinmi MA
Afr J Med Med Sci 2006 Dec;35 Suppl:85-91. PMID: 18050779
Mu-chain disease.
Franklin EC
Arch Intern Med 1975 Jan;135(1):71-2. PMID: 1111471

Therapy

Haemophagocytosis and atypical vacuolated lymphocytes in bone marrow and blood films after SARS-CoV-2 vaccination.
Sassi M, Khefacha L, Merzigui R, Rakez R, Boukhriss S, Laatiri MA
Br J Haematol 2021 Dec;195(5):649. Epub 2021 Jul 27 doi: 10.1111/bjh.17660. PMID: 34312842Free PMC Article
Hairy cell leukemia: clinical, pathological and ultrastructural findings in Asian-Indians.
Chatterjee T, Panigrahi I, Mahapatra M, Pati HP, Kumar R, Naithani R, Wadhwa S, Choudhry VP, Saxena R
Indian J Cancer 2008 Apr-Jun;45(2):41-4. doi: 10.4103/0019-509x.41768. PMID: 18626146
Rash and pancytopenia as initial manifestations of acute graft-versus-host disease after liver transplantation.
Whalen JG, Jukic DM, English JC 3rd
J Am Acad Dermatol 2005 May;52(5):908-12. doi: 10.1016/j.jaad.2005.01.126. PMID: 15858489
Delivery of lipids and liposomal proteins to the cytoplasm and Golgi of antigen-presenting cells. mangala.rao@na.amedd.army.mil.
Rao M, Alving CR
Adv Drug Deliv Rev 2000 Mar 30;41(2):171-88. doi: 10.1016/s0169-409x(99)00064-2. PMID: 10699313
Induction of chromosomal aberrations and SCE by chloramphenicol.
Sbrana I, Caretto S, Rainaldi G, Loprieno N
Mutat Res 1991 May;248(1):145-53. doi: 10.1016/0027-5107(91)90096-7. PMID: 2030703

Prognosis

Xanthoma-like Skin Changes in an Elderly Woman with a Normal Lipid Profile.
Nockowski P, Woźniak Z, Reich A, Maj J
Acta Dermatovenerol Croat 2017 Jul;25(2):167-169. PMID: 28871936
Peripheral blood and bone marrow changes in patients with acquired immunodeficiency syndrome.
Adediran IA, Durosinmi MA
Afr J Med Med Sci 2006 Dec;35 Suppl:85-91. PMID: 18050779
Rash and pancytopenia as initial manifestations of acute graft-versus-host disease after liver transplantation.
Whalen JG, Jukic DM, English JC 3rd
J Am Acad Dermatol 2005 May;52(5):908-12. doi: 10.1016/j.jaad.2005.01.126. PMID: 15858489
Cytomorphology of familial hemophagocytic syndrome.
Silverman JF, Singh HK, Joshi VV, Holbrook CT, Chauvenet AR, Harris LS, Geisinger KR
Diagn Cytopathol 1993 Aug;9(4):404-10. doi: 10.1002/dc.2840090407. PMID: 8261845
Acquired immune deficiency syndrome and pancytopenia.
Spivak JL, Selonick SE, Quinn TC
JAMA 1983 Dec 9;250(22):3084-7. PMID: 6315979

Clinical prediction guides

Bone marrow mesenchymal stem cells alleviate the daunorubicin-induced subacute myocardial injury in rats through inhibiting infiltration of T lymphocytes and antigen-presenting cells.
Chen Q, Zhang Y, Zhu H, Yuan X, Luo X, Wu X, Chen S, Chen Y, Xu J, Issa HA, Zheng Z, Hu J, Yang T
Biomed Pharmacother 2020 Jan;121:109157. Epub 2019 Nov 12 doi: 10.1016/j.biopha.2019.109157. PMID: 31731195
Optimization of adipose tissue-derived mesenchymal stem cells by rapamycin in a murine model of acute graft-versus-host disease.
Kim KW, Moon SJ, Park MJ, Kim BM, Kim EK, Lee SH, Lee EJ, Chung BH, Yang CW, Cho ML
Stem Cell Res Ther 2015 Oct 23;6:202. doi: 10.1186/s13287-015-0197-8. PMID: 26497134Free PMC Article
The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses.
Reyes García MG, García Tamayo F
Biomed Res Int 2013;2013:352414. Epub 2012 Dec 26 doi: 10.1155/2013/352414. PMID: 23509712Free PMC Article
Ultrastructural characteristics of nucleated cells in bone marrow of patients with acquired aplastic anemia.
Ru YX, Zhu XF, Gao JT, Wang HJ, Zhao SX, Feng M, Liu JH, Liu EB, Chen YM, Zhen YZ
Ultrastruct Pathol 2008 May-Jun;32(3):81-8. doi: 10.1080/01913120802063099. PMID: 18570152
Hematologic abnormalities in the acquired immune deficiency syndrome.
Spivak JL, Bender BS, Quinn TC
Am J Med 1984 Aug;77(2):224-8. doi: 10.1016/0002-9343(84)90695-8. PMID: 6465173

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