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Reduced circulating matrix metalloproteinase 2 concentration

MedGen UID:
1841716
•Concept ID:
C5826526
•
Finding
HPO: HP:0034615

Definition

Concentration of matrix metalloproteinase 2 in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating matrix metalloproteinase 2 concentration

Recent clinical studies

Etiology

Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: A randomized controlled trial.
Gao W, Fang F, Xia TJ, Zhang Y, Sun J, Wu Q, Wang W
Microvasc Res 2022 Jul;142:104381. Epub 2022 May 16 doi: 10.1016/j.mvr.2022.104381. PMID: 35588887
Increased activity of MMP-2 in hypertensive obese children is associated with hypoadiponectinemia.
Belo VA, Lacchini R, Miranda JA, Lanna CM, Souza-Costa DC, Tanus-Santos JE
Obesity (Silver Spring) 2015 Jan;23(1):177-82. Epub 2014 Nov 19 doi: 10.1002/oby.20939. PMID: 25407352
Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome.
Gomes VA, Vieira CS, Jacob-Ferreira AL, Belo VA, Soares GM, França JB, Ferriani RA, Tanus-Santos JE
Basic Clin Pharmacol Toxicol 2012 Sep;111(3):211-6. Epub 2012 May 11 doi: 10.1111/j.1742-7843.2012.00895.x. PMID: 22510229
Imbalanced matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 activities in patients with thromboangiitis obliterans.
Dellalibera-Joviliano R, Jacob-Ferreira AL, Joviliano EE, Tanus-Santos JE, Evora PR
Vasc Med 2012 Apr;17(2):73-8. Epub 2012 Mar 8 doi: 10.1177/1358863X11435979. PMID: 22402936
Inverse relationship between markers of nitric oxide formation and plasma matrix metalloproteinase-9 levels in healthy volunteers.
Demacq C, Metzger IF, Gerlach RF, Tanus-Santos JE
Clin Chim Acta 2008 Aug;394(1-2):72-6. Epub 2008 Apr 12 doi: 10.1016/j.cca.2008.04.008. PMID: 18455513

Diagnosis

Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy.
Rysz J, Banach M, Stolarek RA, Pasnik J, Cialkowska-Rysz A, Koktysz R, Piechota M, Baj Z
J Nephrol 2007 Jul-Aug;20(4):444-52. PMID: 17879211

Therapy

Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: A randomized controlled trial.
Gao W, Fang F, Xia TJ, Zhang Y, Sun J, Wu Q, Wang W
Microvasc Res 2022 Jul;142:104381. Epub 2022 May 16 doi: 10.1016/j.mvr.2022.104381. PMID: 35588887
Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome.
Gomes VA, Vieira CS, Jacob-Ferreira AL, Belo VA, Soares GM, França JB, Ferriani RA, Tanus-Santos JE
Basic Clin Pharmacol Toxicol 2012 Sep;111(3):211-6. Epub 2012 May 11 doi: 10.1111/j.1742-7843.2012.00895.x. PMID: 22510229
Imbalanced matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 activities in patients with thromboangiitis obliterans.
Dellalibera-Joviliano R, Jacob-Ferreira AL, Joviliano EE, Tanus-Santos JE, Evora PR
Vasc Med 2012 Apr;17(2):73-8. Epub 2012 Mar 8 doi: 10.1177/1358863X11435979. PMID: 22402936
DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men.
Kelley DS, Siegel D, Fedor DM, Adkins Y, Mackey BE
J Nutr 2009 Mar;139(3):495-501. Epub 2009 Jan 21 doi: 10.3945/jn.108.100354. PMID: 19158225Free PMC Article
Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly.
Paisley AN, O'Callaghan CJ, Lewandowski KC, Parkinson C, Roberts ME, Drake WM, Monson JP, Trainer PJ, Randeva HS
J Clin Endocrinol Metab 2006 Nov;91(11):4635-40. Epub 2006 Aug 22 doi: 10.1210/jc.2005-2589. PMID: 16926249

Prognosis

Decreases in plasma MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios in uremic patients during hemodialysis.
Lu LC, Yang CW, Hsieh WY, Chuang WH, Lin YC, Lin CS
Clin Exp Nephrol 2016 Dec;20(6):934-942. Epub 2015 Dec 28 doi: 10.1007/s10157-015-1221-0. PMID: 26711243

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