U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased circulating biotin concentration

MedGen UID:
1841740
•Concept ID:
C5826511
•
Finding
Synonym: Biotin low in blood
 
HPO: HP:0034599

Definition

Concentration of biotin in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating biotin concentration

Recent clinical studies

Etiology

Metal-Chelating Polymers (MCPs) with Zwitterionic Pendant Groups Complexed to Trastuzumab Exhibit Decreased Liver Accumulation Compared to Polyanionic MCP Immunoconjugates.
Liu P, Boyle AJ, Lu Y, Adams J, Chi Y, Reilly RM, Winnik MA
Biomacromolecules 2015 Nov 9;16(11):3613-23. Epub 2015 Oct 15 doi: 10.1021/acs.biomac.5b01066. PMID: 26469142
Colonic vasoactive intestinal polypeptide (VIP) in ulcerative colitis--a radioimmunoassay and immunohistochemical study.
Todorovic V, Janic B, Koko V, Micev M, Nikolic JA, Ratkovic M, Leposavic G, Jankovic T, Knezevic-Usaj S, Milicevic Z
Hepatogastroenterology 1996 May-Jun;43(9):483-8. PMID: 8799381

Diagnosis

Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.
Das M, Joshi A, Devkar R, Seshadri S, Thakore S
Bioconjug Chem 2022 Feb 16;33(2):369-385. Epub 2022 Jan 11 doi: 10.1021/acs.bioconjchem.1c00614. PMID: 35015523
Palmitoylation of the K(ATP) channel Kir6.2 subunit promotes channel opening by regulating PIP(2) sensitivity.
Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA
Proc Natl Acad Sci U S A 2020 May 12;117(19):10593-10602. Epub 2020 Apr 24 doi: 10.1073/pnas.1918088117. PMID: 32332165Free PMC Article
Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake.
Ungethüm L, Chatrou M, Kusters D, Schurgers L, Reutelingsperger CP
PLoS One 2014;9(5):e96749. Epub 2014 May 6 doi: 10.1371/journal.pone.0096749. PMID: 24801051Free PMC Article

Therapy

Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.
Das M, Joshi A, Devkar R, Seshadri S, Thakore S
Bioconjug Chem 2022 Feb 16;33(2):369-385. Epub 2022 Jan 11 doi: 10.1021/acs.bioconjchem.1c00614. PMID: 35015523
Development of novel biotinylated chitosan-decorated docetaxel-loaded nanocochleates for breast cancer targeting.
Poudel I, Ahiwale R, Pawar A, Mahadik K, Bothiraja C
Artif Cells Nanomed Biotechnol 2018;46(sup2):229-240. Epub 2018 Mar 26 doi: 10.1080/21691401.2018.1453831. PMID: 29575931
Circulating RBC volume, measured with biotinylated RBCs, is superior to the Hct to document the hematologic effects of delayed versus immediate umbilical cord clamping in preterm neonates.
Strauss RG, Mock DM, Johnson K, Mock NI, Cress G, Knosp L, Lobas L, Schmidt RL
Transfusion 2003 Aug;43(8):1168-72. doi: 10.1046/j.1537-2995.2003.00454.x. PMID: 12869126
Effects of nitric oxide on platelet activation during plateletpheresis and in vivo tracking of biotinylated platelets in humans.
Stohlawetz P, Horvath M, Pernerstorfer T, Nguyen H, Vondrovec B, Robisch A, Eichler HG, Spitzauer S, Jilma B
Transfusion 1999 May;39(5):506-14. doi: 10.1046/j.1537-2995.1999.39050506.x. PMID: 10336001
Regulation of the complement-mediated elimination of red blood cells modified with biotin and streptavidin.
Muzykantov VR, Murciano JC, Taylor RP, Atochina EN, Herraez A
Anal Biochem 1996 Oct 1;241(1):109-19. doi: 10.1006/abio.1996.0384. PMID: 8921172

Clinical prediction guides

Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.
Das M, Joshi A, Devkar R, Seshadri S, Thakore S
Bioconjug Chem 2022 Feb 16;33(2):369-385. Epub 2022 Jan 11 doi: 10.1021/acs.bioconjchem.1c00614. PMID: 35015523
Development of novel biotinylated chitosan-decorated docetaxel-loaded nanocochleates for breast cancer targeting.
Poudel I, Ahiwale R, Pawar A, Mahadik K, Bothiraja C
Artif Cells Nanomed Biotechnol 2018;46(sup2):229-240. Epub 2018 Mar 26 doi: 10.1080/21691401.2018.1453831. PMID: 29575931
Effects of nitric oxide on platelet activation during plateletpheresis and in vivo tracking of biotinylated platelets in humans.
Stohlawetz P, Horvath M, Pernerstorfer T, Nguyen H, Vondrovec B, Robisch A, Eichler HG, Spitzauer S, Jilma B
Transfusion 1999 May;39(5):506-14. doi: 10.1046/j.1537-2995.1999.39050506.x. PMID: 10336001

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...