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Increased circulating interleukin 4 concentration

MedGen UID:
1841803
•Concept ID:
C5826432
•
Finding
Synonym: IL-4 high in blood
 
HPO: HP:0034490

Definition

An increased concentration of interleukin-4 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating interleukin 4 concentration

Recent clinical studies

Etiology

Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases.
Calvier L, Drelich A, Hsu J, Tseng CT, Mina Y, Nath A, Kounnas MZ, Herz J
Front Immunol 2023;14:1185748. Epub 2023 Jun 27 doi: 10.3389/fimmu.2023.1185748. PMID: 37441066Free PMC Article
Cytokine profiles in adults with imported malaria.
de Roquetaillade C, Laouenan C, Mira JP, Roy C, Thuong M, Azoulay É, Gruson D, Jacobs F, Chommeloux J, Raffi F, Hocqueloux L, Imbert P, Jeantils V, Delassus JL, Matheron S, Fitting C, Timsit JF, Bruneel F
Sci Rep 2023 Jun 26;13(1):10347. doi: 10.1038/s41598-023-36212-2. PMID: 37365194Free PMC Article
Relationship between circulating senescence-associated secretory phenotype levels and severity of type 2 diabetes-associated periodontitis: A cross-sectional study.
Song X, Yue Z, Fan L, Zou H, Zhao P, Nie L, Zhu K, Jiang J, Lv Q, Wang Q
J Periodontol 2023 Aug;94(8):986-996. Epub 2023 Feb 15 doi: 10.1002/JPER.22-0445. PMID: 36688675
Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder.
Hughes HK, Yang H, Lesh TA, Carter CS, Ashwood P
J Neuroinflammation 2022 Dec 3;19(1):287. doi: 10.1186/s12974-022-02648-y. PMID: 36463221Free PMC Article
Plasma interleukin-4, interleukin-10, and interleukin-13 concentrations and complications after coronary artery bypass graft surgery.
Nathan N, Preux PM, Feiss P, Denizot Y
J Cardiothorac Vasc Anesth 2000 Apr;14(2):156-60. doi: 10.1016/s1053-0770(00)90010-7. PMID: 10794334

Diagnosis

Analysis of Airway Thickening and Serum Cytokines in COPD Patients with Frequent Exacerbations: A Heart of the Matter.
Lin Y, Sang L, Wang J, Chen Y, Lai J, Zhu X, Yang Y, Zhang Z, Liu Y, Wen S, Zhang N, Zhao D
Int J Chron Obstruct Pulmon Dis 2023;18:2353-2364. Epub 2023 Oct 30 doi: 10.2147/COPD.S430650. PMID: 37928768Free PMC Article
Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder.
Hughes HK, Yang H, Lesh TA, Carter CS, Ashwood P
J Neuroinflammation 2022 Dec 3;19(1):287. doi: 10.1186/s12974-022-02648-y. PMID: 36463221Free PMC Article
Serum Amyloid A in Stable COPD Patients is Associated with the Frequent Exacerbator Phenotype.
Zhao D, Abbasi A, Rossiter HB, Su X, Liu H, Pi Y, Sang L, Zhong W, Yang Q, Guo X, Zhou Y, Li T, Casaburi R, Zhang N
Int J Chron Obstruct Pulmon Dis 2020;15:2379-2388. Epub 2020 Sep 30 doi: 10.2147/COPD.S266844. PMID: 33061355Free PMC Article
Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases.
García-Marchena N, Maza-Quiroga R, Serrano A, Barrios V, Requena-Ocaña N, Suárez J, Chowen JA, Argente J, Rubio G, Torrens M, López-Gallardo M, Marco EM, Castilla-Ortega E, Santín LJ, Rodríguez de Fonseca F, Pavón FJ, Araos P
J Psychopharmacol 2020 Nov;34(11):1250-1260. Epub 2020 Jun 13 doi: 10.1177/0269881120928176. PMID: 32536325
Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans.
Suzuki K, Yamada M, Kurakake S, Okamura N, Yamaya K, Liu Q, Kudoh S, Kowatari K, Nakaji S, Sugawara K
Eur J Appl Physiol 2000 Mar;81(4):281-7. doi: 10.1007/s004210050044. PMID: 10664086

Therapy

Analysis of Airway Thickening and Serum Cytokines in COPD Patients with Frequent Exacerbations: A Heart of the Matter.
Lin Y, Sang L, Wang J, Chen Y, Lai J, Zhu X, Yang Y, Zhang Z, Liu Y, Wen S, Zhang N, Zhao D
Int J Chron Obstruct Pulmon Dis 2023;18:2353-2364. Epub 2023 Oct 30 doi: 10.2147/COPD.S430650. PMID: 37928768Free PMC Article
Increased Expression of TLR4 in Circulating CD4+T Cells in Patients with Allergic Conjunctivitis and In Vitro Attenuation of Th2 Inflammatory Response by Alpha-MSH.
Nieto JE, Casanova I, Serna-Ojeda JC, Graue-Hernández EO, Quintana G, Salazar A, Jiménez-Martinez MC
Int J Mol Sci 2020 Oct 23;21(21) doi: 10.3390/ijms21217861. PMID: 33114004Free PMC Article
Immune Response of Healthy Adults to the Ingested Probiotic Lactobacillus casei Shirota.
Harbige LS, Pinto E, Allgrove J, Thomas LV
Scand J Immunol 2016 Dec;84(6):353-364. doi: 10.1111/sji.12495. PMID: 27718254
Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.
Ghoreschi K, Thomas P, Breit S, Dugas M, Mailhammer R, van Eden W, van der Zee R, Biedermann T, Prinz J, Mack M, Mrowietz U, Christophers E, Schlöndorff D, Plewig G, Sander CA, Röcken M
Nat Med 2003 Jan;9(1):40-6. Epub 2002 Dec 2 doi: 10.1038/nm804. PMID: 12461524
Plasma interleukin-4, interleukin-10, and interleukin-13 concentrations and complications after coronary artery bypass graft surgery.
Nathan N, Preux PM, Feiss P, Denizot Y
J Cardiothorac Vasc Anesth 2000 Apr;14(2):156-60. doi: 10.1016/s1053-0770(00)90010-7. PMID: 10794334

Prognosis

Relationship between circulating senescence-associated secretory phenotype levels and severity of type 2 diabetes-associated periodontitis: A cross-sectional study.
Song X, Yue Z, Fan L, Zou H, Zhao P, Nie L, Zhu K, Jiang J, Lv Q, Wang Q
J Periodontol 2023 Aug;94(8):986-996. Epub 2023 Feb 15 doi: 10.1002/JPER.22-0445. PMID: 36688675
Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps.
Zhang F, Xu Z, He X, Sun Y, Zhao C, Zhang J
Mediators Inflamm 2022;2022:7338692. Epub 2022 Apr 8 doi: 10.1155/2022/7338692. PMID: 35431654Free PMC Article
Serum Amyloid A in Stable COPD Patients is Associated with the Frequent Exacerbator Phenotype.
Zhao D, Abbasi A, Rossiter HB, Su X, Liu H, Pi Y, Sang L, Zhong W, Yang Q, Guo X, Zhou Y, Li T, Casaburi R, Zhang N
Int J Chron Obstruct Pulmon Dis 2020;15:2379-2388. Epub 2020 Sep 30 doi: 10.2147/COPD.S266844. PMID: 33061355Free PMC Article
Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases.
García-Marchena N, Maza-Quiroga R, Serrano A, Barrios V, Requena-Ocaña N, Suárez J, Chowen JA, Argente J, Rubio G, Torrens M, López-Gallardo M, Marco EM, Castilla-Ortega E, Santín LJ, Rodríguez de Fonseca F, Pavón FJ, Araos P
J Psychopharmacol 2020 Nov;34(11):1250-1260. Epub 2020 Jun 13 doi: 10.1177/0269881120928176. PMID: 32536325
Serial circulating concentrations of C-reactive protein, interleukin (IL)-4, and IL-6 in patients with acute left heart decompensation.
Sato Y, Takatsu Y, Kataoka K, Yamada T, Taniguchi R, Sasayama S, Matsumori A
Clin Cardiol 1999 Dec;22(12):811-3. doi: 10.1002/clc.4960221211. PMID: 10626084Free PMC Article

Clinical prediction guides

Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases.
Calvier L, Drelich A, Hsu J, Tseng CT, Mina Y, Nath A, Kounnas MZ, Herz J
Front Immunol 2023;14:1185748. Epub 2023 Jun 27 doi: 10.3389/fimmu.2023.1185748. PMID: 37441066Free PMC Article
Relationship between circulating senescence-associated secretory phenotype levels and severity of type 2 diabetes-associated periodontitis: A cross-sectional study.
Song X, Yue Z, Fan L, Zou H, Zhao P, Nie L, Zhu K, Jiang J, Lv Q, Wang Q
J Periodontol 2023 Aug;94(8):986-996. Epub 2023 Feb 15 doi: 10.1002/JPER.22-0445. PMID: 36688675
Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder.
Hughes HK, Yang H, Lesh TA, Carter CS, Ashwood P
J Neuroinflammation 2022 Dec 3;19(1):287. doi: 10.1186/s12974-022-02648-y. PMID: 36463221Free PMC Article
Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps.
Zhang F, Xu Z, He X, Sun Y, Zhao C, Zhang J
Mediators Inflamm 2022;2022:7338692. Epub 2022 Apr 8 doi: 10.1155/2022/7338692. PMID: 35431654Free PMC Article
Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
Mucosal Immunol 2012 Mar;5(2):140-9. Epub 2011 Dec 21 doi: 10.1038/mi.2011.60. PMID: 22189956

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