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Elevated brain glutamine level by MRS

MedGen UID:
1841826
•Concept ID:
C5826435
•
Finding
HPO: HP:0034495

Definition

An increased in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated brain glutamine level by MRS

Professional guidelines

PubMed

Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder: A Longitudinal 1H Magnetic Resonance Spectroscopy Study.
Ermis C, Aydin B, Kucukguclu S, Yurt A, Renshaw PF, Yildiz A
J ECT 2021 Dec 1;37(4):263-269. doi: 10.1097/YCT.0000000000000766. PMID: 33840802
Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment.
Subramani E, Radoul M, Najac C, Batsios G, Molloy AR, Hong D, Gillespie AM, Santos RD, Viswanath P, Costello JF, Pieper RO, Ronen SM
Cancer Res 2020 Nov 15;80(22):5098-5108. Epub 2020 Sep 21 doi: 10.1158/0008-5472.CAN-20-1314. PMID: 32958546Free PMC Article
Glutamatergic neurometabolites and cortical thickness in treatment-resistant schizophrenia: Implications for glutamate-mediated excitotoxicity.
Shah P, Plitman E, Iwata Y, Kim J, Nakajima S, Chan N, Brown EE, Caravaggio F, Torres E, Hahn M, Chakravarty MM, Remington G, Gerretsen P, Graff-Guerrero A
J Psychiatr Res 2020 May;124:151-158. Epub 2020 Mar 5 doi: 10.1016/j.jpsychires.2020.02.032. PMID: 32169688

Recent clinical studies

Etiology

In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET, (1)H-MRS, and MRI.
Watts JJ, Guma E, Chavez S, Tyndale RF, Ross RA, Houle S, Wilson AA, Chakravarty M, Rusjan PM, Mizrahi R
Neuropsychopharmacology 2022 Oct;47(11):1984-1991. Epub 2022 Jul 29 doi: 10.1038/s41386-022-01384-4. PMID: 35906490Free PMC Article
Increased prefrontal GABA concentrations in adults with autism spectrum disorders.
Maier S, Düppers AL, Runge K, Dacko M, Lange T, Fangmeier T, Riedel A, Ebert D, Endres D, Domschke K, Perlov E, Nickel K, Tebartz van Elst L
Autism Res 2022 Jul;15(7):1222-1236. Epub 2022 May 19 doi: 10.1002/aur.2740. PMID: 35587691
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Glutamatergic Correlates of Bipolar Symptoms in Adolescents.
Sonmez AI, Lewis CP, Port JD, Cabello-Arreola A, Blacker CJ, Seewoo BJ, McKean AJ, Leffler JM, Frye MA, Croarkin PE
J Child Adolesc Psychopharmacol 2020 Dec;30(10):599-605. Epub 2020 Nov 11 doi: 10.1089/cap.2020.0082. PMID: 33179961Free PMC Article
Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes.
Oeltzschner G, Butz M, Wickrath F, Wittsack HJ, Schnitzler A
Metab Brain Dis 2016 Jun;31(3):517-27. Epub 2015 Nov 12 doi: 10.1007/s11011-015-9760-3. PMID: 26563124

Diagnosis

In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET, (1)H-MRS, and MRI.
Watts JJ, Guma E, Chavez S, Tyndale RF, Ross RA, Houle S, Wilson AA, Chakravarty M, Rusjan PM, Mizrahi R
Neuropsychopharmacology 2022 Oct;47(11):1984-1991. Epub 2022 Jul 29 doi: 10.1038/s41386-022-01384-4. PMID: 35906490Free PMC Article
Effects of sex hormones on brain GABA and glutamate levels in a cis- and transgender cohort.
Spurny-Dworak B, Handschuh P, Spies M, Kaufmann U, Seiger R, Klöbl M, Konadu ME, Reed MB, Ritter V, Baldinger-Melich P, Bogner W, Kranz GS, Lanzenberger R
Psychoneuroendocrinology 2022 Apr;138:105683. Epub 2022 Feb 1 doi: 10.1016/j.psyneuen.2022.105683. PMID: 35176535
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Glutamatergic Correlates of Bipolar Symptoms in Adolescents.
Sonmez AI, Lewis CP, Port JD, Cabello-Arreola A, Blacker CJ, Seewoo BJ, McKean AJ, Leffler JM, Frye MA, Croarkin PE
J Child Adolesc Psychopharmacol 2020 Dec;30(10):599-605. Epub 2020 Nov 11 doi: 10.1089/cap.2020.0082. PMID: 33179961Free PMC Article
Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy.
Harris RE, Clauw DJ
Neurosci Lett 2012 Jun 29;520(2):192-6. Epub 2012 Mar 22 doi: 10.1016/j.neulet.2012.03.042. PMID: 22445845

Therapy

Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics.
Avgerinos KI, Mullins RJ, Vreones M, Mustapic M, Chen Q, Melvin D, Kapogiannis D, Egan JM
Cells 2022 Oct 25;11(21) doi: 10.3390/cells11213372. PMID: 36359767Free PMC Article
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment.
Subramani E, Radoul M, Najac C, Batsios G, Molloy AR, Hong D, Gillespie AM, Santos RD, Viswanath P, Costello JF, Pieper RO, Ronen SM
Cancer Res 2020 Nov 15;80(22):5098-5108. Epub 2020 Sep 21 doi: 10.1158/0008-5472.CAN-20-1314. PMID: 32958546Free PMC Article
Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy.
Harris RE, Clauw DJ
Neurosci Lett 2012 Jun 29;520(2):192-6. Epub 2012 Mar 22 doi: 10.1016/j.neulet.2012.03.042. PMID: 22445845

Prognosis

Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder: A Longitudinal 1H Magnetic Resonance Spectroscopy Study.
Ermis C, Aydin B, Kucukguclu S, Yurt A, Renshaw PF, Yildiz A
J ECT 2021 Dec 1;37(4):263-269. doi: 10.1097/YCT.0000000000000766. PMID: 33840802
Choline elevation in amygdala region at recovery indicates longer survival without depressive episode: a magnetic resonance spectroscopy study.
Henigsberg N, Savić A, Radoš M, Radoš M, Šarac H, Šečić A, Bajs Janović M, Foro T, Ozretić D, Erdeljić Turk V, Hrabač P, Kalember P
Psychopharmacology (Berl) 2021 May;238(5):1303-1314. Epub 2019 Sep 4 doi: 10.1007/s00213-019-05303-2. PMID: 31482202Free PMC Article
Glutamatergic Correlates of Bipolar Symptoms in Adolescents.
Sonmez AI, Lewis CP, Port JD, Cabello-Arreola A, Blacker CJ, Seewoo BJ, McKean AJ, Leffler JM, Frye MA, Croarkin PE
J Child Adolesc Psychopharmacol 2020 Dec;30(10):599-605. Epub 2020 Nov 11 doi: 10.1089/cap.2020.0082. PMID: 33179961Free PMC Article
Glutamatergic and GABA-ergic abnormalities in First-episode depression. A 1-year follow-up 1H-MR spectroscopic study.
Draganov M, Vives-Gilabert Y, de Diego-Adeliño J, Vicent-Gil M, Puigdemont D, Portella MJ
J Affect Disord 2020 Apr 1;266:572-577. Epub 2020 Jan 26 doi: 10.1016/j.jad.2020.01.138. PMID: 32056929
Magnetic resonance imaging and spectroscopy of the brain in propionic acidemia: clinical and biochemical considerations.
Bergman AJ, Van der Knaap MS, Smeitink JA, Duran M, Dorland L, Valk J, Poll-The BT
Pediatr Res 1996 Sep;40(3):404-9. doi: 10.1203/00006450-199609000-00007. PMID: 8865276

Clinical prediction guides

Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Glutamatergic Correlates of Bipolar Symptoms in Adolescents.
Sonmez AI, Lewis CP, Port JD, Cabello-Arreola A, Blacker CJ, Seewoo BJ, McKean AJ, Leffler JM, Frye MA, Croarkin PE
J Child Adolesc Psychopharmacol 2020 Dec;30(10):599-605. Epub 2020 Nov 11 doi: 10.1089/cap.2020.0082. PMID: 33179961Free PMC Article
Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A (1)H-MRS and pCASL study.
Wijtenburg SA, Wright SN, Korenic SA, Gaston FE, Ndubuizu N, Chiappelli J, McMahon RP, Chen H, Savransky A, Du X, Wang DJ, Kochunov P, Hong LE, Rowland LM
Neuropsychopharmacology 2017 Jan;42(2):562-571. Epub 2016 Aug 26 doi: 10.1038/npp.2016.172. PMID: 27562377Free PMC Article
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632

Recent systematic reviews

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632
Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis.
Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN
Bipolar Disord 2012 Aug;14(5):478-87. doi: 10.1111/j.1399-5618.2012.01033.x. PMID: 22834460

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