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Abnormal circulating erythropoietin concentration

MedGen UID:
1841862
•Concept ID:
C5826395
•
Finding
HPO: HP:0034442

Definition

Any deviation from the normal concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating erythropoietin concentration

Recent clinical studies

Etiology

The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.
Kowalska-Kańka A, Maciejewski T, Niemiec KT
Med Wieku Rozwoj 2013 Jul-Sep;17(3):232-45. PMID: 24296447
Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation.
Jimenez-Zepeda VH, Trudel S, Reece DE, Chen C, Rabea AM, Kukreti V
Am J Hematol 2011 Oct;86(10):873-5. Epub 2011 Aug 3 doi: 10.1002/ajh.22115. PMID: 21815185
Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial.
Sörgel F, Thyroff-Friesinger U, Vetter A, Vens-Cappell B, Kinzig M
BMC Clin Pharmacol 2009 May 22;9:10. doi: 10.1186/1472-6904-9-10. PMID: 19463151Free PMC Article
Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders.
Prchal JT
Semin Hematol 2001 Jan;38(1 Suppl 2):10-20. doi: 10.1016/s0037-1963(01)90135-0. PMID: 11242597
Umbilical venous erythropoietin and umbilical arterial pH in relation to morphologic placental abnormalities.
Maier RF, Günther A, Vogel M, Dudenhausen JW, Obladen M
Obstet Gynecol 1994 Jul;84(1):81-7. PMID: 8008330

Diagnosis

Placental delayed villous maturation is associated with evidence of chronic fetal hypoxia.
Jaiman S, Romero R, Pacora P, Jung EJ, Kacerovsky M, Bhatti G, Yeo L, Hsu CD
J Perinat Med 2020 Jun 25;48(5):516-518. doi: 10.1515/jpm-2020-0014. PMID: 32396141Free PMC Article
Evaluation of six erythropoietin kits.
Marsden JT, Sherwood RA, Peters TJ
Ann Clin Biochem 1999 May;36 ( Pt 3):380-7. doi: 10.1177/000456329903600312. PMID: 10376082

Therapy

Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation.
Jimenez-Zepeda VH, Trudel S, Reece DE, Chen C, Rabea AM, Kukreti V
Am J Hematol 2011 Oct;86(10):873-5. Epub 2011 Aug 3 doi: 10.1002/ajh.22115. PMID: 21815185
Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial.
Sörgel F, Thyroff-Friesinger U, Vetter A, Vens-Cappell B, Kinzig M
BMC Clin Pharmacol 2009 May 22;9:10. doi: 10.1186/1472-6904-9-10. PMID: 19463151Free PMC Article
Indirect evidence of hormone abuse. Proof of doping?
Minuto F, Barreca A, Melioli G
J Endocrinol Invest 2003 Sep;26(9):919-23. doi: 10.1007/BF03345244. PMID: 14964446
Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders.
Prchal JT
Semin Hematol 2001 Jan;38(1 Suppl 2):10-20. doi: 10.1016/s0037-1963(01)90135-0. PMID: 11242597
Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis.
Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A
Blood 1996 Jun 1;87(11):4824-30. PMID: 8639855

Prognosis

The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.
Kowalska-Kańka A, Maciejewski T, Niemiec KT
Med Wieku Rozwoj 2013 Jul-Sep;17(3):232-45. PMID: 24296447
Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial.
Sörgel F, Thyroff-Friesinger U, Vetter A, Vens-Cappell B, Kinzig M
BMC Clin Pharmacol 2009 May 22;9:10. doi: 10.1186/1472-6904-9-10. PMID: 19463151Free PMC Article
Serum erythropoietin levels in patients with sepsis and septic shock.
Abel J, Spannbrucker N, Fandrey J, Jelkmann W
Eur J Haematol 1996 Nov;57(5):359-63. doi: 10.1111/j.1600-0609.1996.tb01393.x. PMID: 9003476
Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis.
Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A
Blood 1996 Jun 1;87(11):4824-30. PMID: 8639855

Clinical prediction guides

The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.
Kowalska-Kańka A, Maciejewski T, Niemiec KT
Med Wieku Rozwoj 2013 Jul-Sep;17(3):232-45. PMID: 24296447
Indirect evidence of hormone abuse. Proof of doping?
Minuto F, Barreca A, Melioli G
J Endocrinol Invest 2003 Sep;26(9):919-23. doi: 10.1007/BF03345244. PMID: 14964446
Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis.
Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A
Blood 1996 Jun 1;87(11):4824-30. PMID: 8639855
Serum immunoreactive erythropoietin and erythropoiesis in protein-energy malnutrition.
Wickramasinghe SN, Cotes PM, Gill DS, Tam RC, Grange A, Akinyanju OO
Br J Haematol 1985 Jul;60(3):515-24. doi: 10.1111/j.1365-2141.1985.tb07448.x. PMID: 3925982
Measurement of human erythroid burst-promoting activity by a specific cell culture assay.
Dukes PP, Ma A, Clemons GK, Meytes D
Exp Hematol 1985 Jan;13(1):59-66. PMID: 3871703

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