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Reduced epidermal bullous pemphigoid antigen 1 protein expression

MedGen UID:: 1841899
•Concept ID:: C5826491
•: Finding

Synonym:	Skin biopsy: BPAG1-e antibody staining abnormal or absent

HPO:	HP:0034576

Definition

Lower than normal amount of bullous pemphigoid antigen 1 (BP230) in the epidermis. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVReduced epidermal bullous pemphigoid antigen 1 protein expression

Phenotypic abnormality
- Abnormality of the integument
  - Abnormality of the skin
    - Abnormal skin morphology
      - Abnormal epidermal morphology
        Abnormal epidermal protein expression
        Reduced epidermal bullous pemphigoid antigen 1 protein expression

Recent clinical studies

Diagnosis

Production of the entire extracellular domain of BP180 (type XVII collagen) by baculovirus expression.

Hata Y, Fujii Y, Tsunoda K, Amagai M
J Dermatol Sci 2000 Aug;23(3):183-90. doi: 10.1016/s0923-1811(00)00074-8. PMID: 10959044

Clinical prediction guides

Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes.

Westgate GE, Weaver AC, Couchman JR
J Invest Dermatol 1985 Mar;84(3):218-24. doi: 10.1111/1523-1747.ep12265229. PMID: 2579167

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