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Pancreatic hamartoma

MedGen UID:
1841921
•Concept ID:
C5826692
•
Neoplastic Process
HPO: HP:0034831

Definition

A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the pancreas. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic hamartoma

Professional guidelines

PubMed

Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology
Am J Gastroenterol 2015 Feb;110(2):223-62; quiz 263. Epub 2015 Feb 3 doi: 10.1038/ajg.2014.435. PMID: 25645574Free PMC Article
Upper gastrointestinal submucosal lesions--clinical and endosonographic evaluation and management.
Bhatia V, Tajika M, Rastogi A
Trop Gastroenterol 2010 Jan-Mar;31(1):5-29. PMID: 20860221

Recent clinical studies

Etiology

Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound-guided fine-needle aspiration biopsy.
Shintaku H, Gokita K, Oshima T, Suzuki K, Fujii K, Sugaya N, Tomii S, Onishi I, Shimada K, Ohashi K
Diagn Cytopathol 2023 Sep;51(9):E267-E272. Epub 2023 May 31 doi: 10.1002/dc.25174. PMID: 37255003
Pancreatic Lipomatous Hamartoma: A Hitherto Unrecognized Variant.
Tanaka M, Ushiku T, Ikemura M, Takazawa Y, Igari T, Shimizu M, Yamaguchi H, Fukushima N, Sakuma K, Arita J, Sakamoto Y, Hasegawa K, Watadani T, Nakai Y, Koike K, Fukayama M
Am J Surg Pathol 2018 Jul;42(7):891-897. doi: 10.1097/PAS.0000000000001075. PMID: 29738363
"Paraduodenal" pancreatitis: results of surgery on 58 consecutives patients from a single institution.
Casetti L, Bassi C, Salvia R, Butturini G, Graziani R, Falconi M, Frulloni L, Crippa S, Zamboni G, Pederzoli P
World J Surg 2009 Dec;33(12):2664-9. doi: 10.1007/s00268-009-0238-5. PMID: 19809849
Multicystic pancreatic hamartoma: a distinctive lesion with immunohistochemical and ultrastructural study.
Flaherty MJ, Benjamin DR
Hum Pathol 1992 Nov;23(11):1309-12. doi: 10.1016/0046-8177(92)90301-i. PMID: 1427759

Diagnosis

Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound-guided fine-needle aspiration biopsy.
Shintaku H, Gokita K, Oshima T, Suzuki K, Fujii K, Sugaya N, Tomii S, Onishi I, Shimada K, Ohashi K
Diagn Cytopathol 2023 Sep;51(9):E267-E272. Epub 2023 May 31 doi: 10.1002/dc.25174. PMID: 37255003
Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene.
Tanigawa M, Koga Y, Naito Y, Yamaguchi H, Iwasaki T, Kohashi K, Ohike N, Hanada K, Higashi M, Komatsu M, Imai H, Yamakita K, Nagakawa T, Okabe Y, Kato S, Noguchi H, Nakayama T, Yasuda M, Kusano H, Akiba J, Oda Y, Yano H
Histopathology 2022 Sep;81(3):319-328. Epub 2022 Jul 14 doi: 10.1111/his.14703. PMID: 35758200
Pancreatic Hamartoma Difficult to Diagnose Preoperatively.
Noguchi T, Ryozawa S, Mizuide M, Tanisaka Y, Fujita A, Ogawa T, Suzuki M, Katsuda H, Nagata K, Kawasaki T, Aikawa M, Okamoto K
Intern Med 2021 Jul 1;60(13):2055-2059. Epub 2021 Feb 1 doi: 10.2169/internalmedicine.5982-20. PMID: 33518562Free PMC Article
Pancreatic hamartoma.
Addeo P, Tudor G, Oussoultzoglou E, Averous G, Bachellier P
Surgery 2014 Nov;156(5):1284-5. Epub 2013 May 4 doi: 10.1016/j.surg.2013.02.021. PMID: 23652195
Pancreatic hamartoma.
McFaul CD, Vitone LJ, Campbell F, Azadeh B, Hughes ML, Garvey CJ, Ghaneh P, Neoptolemos JP
Pancreatology 2004;4(6):533-7; discussion 537-8. Epub 2004 Aug 30 doi: 10.1159/000080528. PMID: 15340246

Prognosis

Rare case of pancreatic lipomatous hamartoma.
Tee CL, Lin EY, Bundele MM, Low JK
BMJ Case Rep 2022 Apr 7;15(4) doi: 10.1136/bcr-2021-248132. PMID: 35393275Free PMC Article
Pancreatic hamartoma and SAPHO syndrome: a case report.
Sampelean D, Adam M, Muntean V, Hanescu B, Domsa I
J Gastrointestin Liver Dis 2009 Dec;18(4):483-6. PMID: 20076824
Solid pancreatic hamartoma.
Nagata S, Yamaguchi K, Inoue T, Yamaguchi H, Ito T, Gibo J, Tanaka M, Tsuneyoshi M
Pathol Int 2007 May;57(5):276-80. doi: 10.1111/j.1440-1827.2007.02090.x. PMID: 17493175

Clinical prediction guides

Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound-guided fine-needle aspiration biopsy.
Shintaku H, Gokita K, Oshima T, Suzuki K, Fujii K, Sugaya N, Tomii S, Onishi I, Shimada K, Ohashi K
Diagn Cytopathol 2023 Sep;51(9):E267-E272. Epub 2023 May 31 doi: 10.1002/dc.25174. PMID: 37255003
Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene.
Tanigawa M, Koga Y, Naito Y, Yamaguchi H, Iwasaki T, Kohashi K, Ohike N, Hanada K, Higashi M, Komatsu M, Imai H, Yamakita K, Nagakawa T, Okabe Y, Kato S, Noguchi H, Nakayama T, Yasuda M, Kusano H, Akiba J, Oda Y, Yano H
Histopathology 2022 Sep;81(3):319-328. Epub 2022 Jul 14 doi: 10.1111/his.14703. PMID: 35758200
A case of pancreatic hamartoma with characteristic radiological findings: radiological-pathological correlation.
Toyama K, Matsusaka Y, Okuda S, Miura E, Kubota N, Masugi Y, Kitago M, Hori S, Yokose T, Shinoda M, Sakamoto M, Jinzaki M
Abdom Radiol (NY) 2020 Jul;45(7):2244-2248. doi: 10.1007/s00261-020-02425-6. PMID: 32016502
Distinctive histopathologic findings of pancreatic hamartomas suggesting their "hamartomatous" nature: a study of 9 cases.
Yamaguchi H, Aishima S, Oda Y, Mizukami H, Tajiri T, Yamada S, Tasaki T, Yamakita K, Imai K, Kawakami F, Hara S, Hanada K, Iiboshi T, Fukuda T, Imai H, Inoue H, Nagakawa T, Muraoka S, Furukawa T, Shimizu M
Am J Surg Pathol 2013 Jul;37(7):1006-13. doi: 10.1097/PAS.0b013e318283ce4c. PMID: 23715157
Pancreatic hamartoma and SAPHO syndrome: a case report.
Sampelean D, Adam M, Muntean V, Hanescu B, Domsa I
J Gastrointestin Liver Dis 2009 Dec;18(4):483-6. PMID: 20076824

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