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Decreased circulating transcobalamin II concentration

MedGen UID:
1841932
•Concept ID:
C5826520
•
Finding
Synonym: Transcobalamin II low in blood
 
HPO: HP:0034608

Definition

Concentration of transcobalamin II in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating transcobalamin II concentration

Professional guidelines

PubMed

Effect of vitamin B12 treatment on haptocorrin.
Mørkbak AL, Hvas AM, Lloyd-Wright Z, Sanders TA, Bleie O, Refsum H, Nygaard OK, Nexø E
Clin Chem 2006 Jun;52(6):1104-11. Epub 2006 Apr 13 doi: 10.1373/clinchem.2005.061549. PMID: 16613998

Recent clinical studies

Etiology

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
A genetic variant in vitamin B12 metabolic genes that reduces the risk of congenital heart disease in Han Chinese populations.
Wang J, Zhao JY, Wang F, Peng QQ, Hou J, Sun SN, Gui YH, Duan WY, Qiao B, Wang HY
PLoS One 2014;9(2):e88332. Epub 2014 Feb 12 doi: 10.1371/journal.pone.0088332. PMID: 24533076Free PMC Article
A longitudinal study of serum cobalamins and its binding proteins in lactating women.
Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E
Eur J Clin Nutr 2007 Feb;61(2):184-9. Epub 2006 Aug 9 doi: 10.1038/sj.ejcn.1602502. PMID: 16900082
Effect of vitamin B12 treatment on haptocorrin.
Mørkbak AL, Hvas AM, Lloyd-Wright Z, Sanders TA, Bleie O, Refsum H, Nygaard OK, Nexø E
Clin Chem 2006 Jun;52(6):1104-11. Epub 2006 Apr 13 doi: 10.1373/clinchem.2005.061549. PMID: 16613998
Increased circulating levels of transcobalamin II in malarial patients with renal involvement.
Areekul S, Churdchu K, Wilairatana P, Charoenlarp P
Ann Trop Med Parasitol 1993 Feb;87(1):17-22. doi: 10.1080/00034983.1993.11812735. PMID: 8346988

Diagnosis

Serum transcobalamin II level in glucose-6-phosphate dehydrogenase deficient subjects with typhoid fever.
Areekul S, Paksanond S, Thanomsak W, Vatanavicharn S
J Med Assoc Thai 1996 May;79(5):325-9. PMID: 8708525
Staging vitamin B-12 (cobalamin) status in vegetarians.
Herbert V
Am J Clin Nutr 1994 May;59(5 Suppl):1213S-1222S. doi: 10.1093/ajcn/59.5.1213S. PMID: 8172125

Therapy

Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment.
Gatford KL, Houda CM, Lu ZX, Coat S, Baghurst PA, Owens JA, Sikaris K, Rowan JA, Hague WM
Diabetes Obes Metab 2013 Jul;15(7):660-7. Epub 2013 Feb 28 doi: 10.1111/dom.12080. PMID: 23402546
A longitudinal study of serum cobalamins and its binding proteins in lactating women.
Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E
Eur J Clin Nutr 2007 Feb;61(2):184-9. Epub 2006 Aug 9 doi: 10.1038/sj.ejcn.1602502. PMID: 16900082
Effect of vitamin B12 treatment on haptocorrin.
Mørkbak AL, Hvas AM, Lloyd-Wright Z, Sanders TA, Bleie O, Refsum H, Nygaard OK, Nexø E
Clin Chem 2006 Jun;52(6):1104-11. Epub 2006 Apr 13 doi: 10.1373/clinchem.2005.061549. PMID: 16613998
Staging vitamin B-12 (cobalamin) status in vegetarians.
Herbert V
Am J Clin Nutr 1994 May;59(5 Suppl):1213S-1222S. doi: 10.1093/ajcn/59.5.1213S. PMID: 8172125

Prognosis

A longitudinal study of serum cobalamins and its binding proteins in lactating women.
Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E
Eur J Clin Nutr 2007 Feb;61(2):184-9. Epub 2006 Aug 9 doi: 10.1038/sj.ejcn.1602502. PMID: 16900082

Clinical prediction guides

Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
Boachie J, Adaikalakoteswari A, Goljan I, Samavat J, Cagampang FR, Saravanan P
Int J Mol Sci 2021 Mar 17;22(6) doi: 10.3390/ijms22063089. PMID: 33803025Free PMC Article
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
A longitudinal study of serum cobalamins and its binding proteins in lactating women.
Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E
Eur J Clin Nutr 2007 Feb;61(2):184-9. Epub 2006 Aug 9 doi: 10.1038/sj.ejcn.1602502. PMID: 16900082
Effect of vitamin B12 treatment on haptocorrin.
Mørkbak AL, Hvas AM, Lloyd-Wright Z, Sanders TA, Bleie O, Refsum H, Nygaard OK, Nexø E
Clin Chem 2006 Jun;52(6):1104-11. Epub 2006 Apr 13 doi: 10.1373/clinchem.2005.061549. PMID: 16613998
Inhibition of vitamin B12 binding to transcobalamin II at low pH: basis of a procedure for quantitation of circulating TC II and R binders.
Gilbert HS
J Lab Clin Med 1977 Jan;89(1):13-24. PMID: 12239

Recent systematic reviews

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article

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