Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Reduced erythrocyte glutathione concentration

MedGen UID:: 1841986
•Concept ID:: C5826627
•: Finding

HPO:	HP:0034738

Definition

Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVReduced erythrocyte glutathione concentration

Phenotypic abnormality
- Abnormality of blood and blood-forming tissues
  - Abnormal erythrocyte morphology
    - Abnormal erythrocyte metabolite concentration
      - Reduced erythrocyte glutathione concentration

Professional guidelines

PubMed

Development and In Vivo Evaluation of Pectin Based Enteric Coated Microparticles Loaded with Mesalamine and Saccharomyces boulardii for Management of Ulcerative Colitis.

Singh A, Mandal UK, Narang RK
Assay Drug Dev Technol 2022 Jan;20(1):22-34. Epub 2021 Nov 15 doi: 10.1089/adt.2021.052. PMID: 34780287

Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency.

Seghrouchni I, Drai J, Bannier E, Rivière J, Calmard P, Garcia I, Orgiazzi J, Revol A
Clin Chim Acta 2002 Jul;321(1-2):89-96. doi: 10.1016/s0009-8981(02)00099-2. PMID: 12031597

Metabolic and cellular basis of 2-butoxyethanol-induced hemolytic anemia in rats and assessment of human risk in vitro.

Ghanayem BI
Biochem Pharmacol 1989 May 15;38(10):1679-84. doi: 10.1016/0006-2952(89)90317-1. PMID: 2730682

See all (11)

Recent clinical studies

Etiology

Evaluation of the efficacy and safety of amustaline/glutathione pathogen-reduced RBCs in complex cardiac surgery: the Red Cell Pathogen Inactivation (ReCePI) study-protocol for a phase 3, randomized, controlled trial.

Snyder EL, Sekela ME, Welsby IJ, Toyoda Y, Alsammak M, Sodha NR, Beaver TM, Pelletier JPR, Gorham JD, McNeil JS, Sniecinski RM, Pearl RG, Nuttall GA, Sarode R, Reece TB, Kaplan A, Davenport RD, Ipe TS, Benharash P, Lopez-Plaza I, Gammon RR, Sadler P, Pitman JP, Liu K, Bentow S, Corash L, Mufti N, Varrone J, Benjamin RJ; for the ReCePI study group
Trials 2023 Dec 11;24(1):799. doi: 10.1186/s13063-023-07831-x. PMID: 38082326 Free PMC Article

Erythropoietin Resistance Development in Hemodialysis Patients: The Role of Oxidative Stress.

Joksimovic Jovic J, Antic S, Nikolic T, Andric K, Petrovic D, Bolevich S, Jakovljevic V
Oxid Med Cell Longev 2022;2022:9598211. Epub 2022 Apr 14 doi: 10.1155/2022/9598211. PMID: 35464768 Free PMC Article

Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer's disease.

Zalewska A, Klimiuk A, Zięba S, Wnorowska O, Rusak M, Waszkiewicz N, Szarmach I, Dzierżanowski K, Maciejczyk M
Sci Rep 2021 Dec 13;11(1):23904. doi: 10.1038/s41598-021-03456-9. PMID: 34903846 Free PMC Article

Eryptosis in lead-exposed workers.

Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684

Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis.

Swietek K, Juszczyk J
J Viral Hepat 1997 Mar;4(2):139-41. doi: 10.1111/j.1365-2893.1997.tb00217.x. PMID: 9097271

See all (280)

Diagnosis

Erythrocyte Lipid and Antioxidant Changes in Plasmodium falciparum-infected Children Attending Mother and Child Hospital in Akure, Nigeria.

Oluba OM
Pak J Biol Sci 2019 Jan;22(6):257-264. doi: 10.3923/pjbs.2019.257.264. PMID: 31930848

Eryptosis in lead-exposed workers.

Simultaneous analysis of reduced glutathione and glutathione disulfide by capillary zone electrophoresis.

Hempe JM, Ory-Ascani J
Electrophoresis 2014 Apr;35(7):967-71. Epub 2014 Feb 8 doi: 10.1002/elps.201300450. PMID: 24338531

Alterations in erythrocyte glutathione metabolism associated with cervical dysplasias and carcinoma in situ.

Basu J, Duttagupta C, Vermund SH, Ahn C, Palan PR, Romney SL
Cancer Invest 1993;11(6):652-9. doi: 10.3109/07357909309046937. PMID: 8221197

See all (90)

Therapy

Erythropoietin Resistance Development in Hemodialysis Patients: The Role of Oxidative Stress.

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends.

Ścibior A, Pietrzyk Ł, Plewa Z, Skiba A
J Trace Elem Med Biol 2020 Sep;61:126508. Epub 2020 Apr 12 doi: 10.1016/j.jtemb.2020.126508. PMID: 32305626 Free PMC Article

Erythrocyte Lipid and Antioxidant Changes in Plasmodium falciparum-infected Children Attending Mother and Child Hospital in Akure, Nigeria.

Oluba OM
Pak J Biol Sci 2019 Jan;22(6):257-264. doi: 10.3923/pjbs.2019.257.264. PMID: 31930848

Eryptosis in lead-exposed workers.

Dapsone toxicity: some current perspectives.

Coleman MD
Gen Pharmacol 1995 Nov;26(7):1461-7. doi: 10.1016/0306-3623(95)00029-1. PMID: 8690232

See all (193)

Prognosis

Impaired Enzymatic Antioxidant Defense in Erythrocytes of Rats with Ammonia-Induced Encephalopathy: Role of NMDA Receptors.

Kosenko EA, Alilova GA, Tikhonova LA
Biochemistry (Mosc) 2023 Sep;88(9):1404-1415. doi: 10.1134/S0006297923090195. PMID: 37770406

Antioxidative mechanism in the course of varicose veins.

Horecka A, Biernacka J, Hordyjewska A, Dąbrowski W, Terlecki P, Zubilewicz T, Musik I, Kurzepa J
Phlebology 2018 Aug;33(7):464-469. Epub 2017 Jul 14 doi: 10.1177/0268355517721055. PMID: 28705052

Acute consumption of organic and conventional tropical grape juices (Vitis labrusca L.) increases antioxidants in plasma and erythrocytes, but not glucose and uric acid levels, in healthy individuals.

Toaldo IM, Cruz FA, da Silva EL, Bordignon-Luiz MT
Nutr Res 2016 Aug;36(8):808-17. Epub 2016 Apr 29 doi: 10.1016/j.nutres.2016.04.010. PMID: 27440535

Changes in the erythrocyte glutathione concentration in the course of diabetes mellitus.

Nwose EU, Jelinek HF, Richards RS, Kerr PG
Redox Rep 2006;11(3):99-104. doi: 10.1179/135100006X116583. PMID: 16805963

Plasma selenium concentration and glutathione peroxidase activity in HIV-1/AIDS infected patients: a correlation with the disease progression.

Ogunro PS, Ogungbamigbe TO, Elemie PO, Egbewale BE, Adewole TA
Niger Postgrad Med J 2006 Mar;13(1):1-5. PMID: 16633369

See all (34)

Clinical prediction guides

Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer's disease.

Erythrocyte Lipid and Antioxidant Changes in Plasmodium falciparum-infected Children Attending Mother and Child Hospital in Akure, Nigeria.

Oluba OM
Pak J Biol Sci 2019 Jan;22(6):257-264. doi: 10.3923/pjbs.2019.257.264. PMID: 31930848

Uremia and Hypoxia Independently Induce Eryptosis and Erythrocyte Redox Imbalance.

Tozoni SS, Dias GF, Bohnen G, Grobe N, Pecoits-Filho R, Kotanko P, Moreno-Amaral AN
Cell Physiol Biochem 2019;53:794-804. doi: 10.33594/000000173. PMID: 31661199

Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate.

Cakir Y, Yildiz D
Blood Cells Mol Dis 2013 Jan;50(1):1-7. Epub 2012 Jul 22 doi: 10.1016/j.bcmd.2012.07.001. PMID: 22824382

Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis.

Swietek K, Juszczyk J
J Viral Hepat 1997 Mar;4(2):139-41. doi: 10.1111/j.1365-2893.1997.tb00217.x. PMID: 9097271

See all (231)