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Abnormal gamma-glutamyltransferase level

MedGen UID:
1842000
•Concept ID:
C5826397
•
Finding
HPO: HP:0034444

Definition

Any deviation from the normal level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal gamma-glutamyltransferase level

Professional guidelines

PubMed

Analysis of gamma-glutamyltransferase in acute promyelocytic leukemia patients undergoing arsenic trioxide treatment.
Sui M, Wei H, Zhang Q, Xiu R, Shen X, Zhang Z, Zhou J
Hematology 2021 Dec;26(1):58-64. doi: 10.1080/16078454.2020.1868782. PMID: 33402059
Laboratory test based assessment of WHO alcohol risk drinking levels.
Niemelä O, Nivukoski U, Bloigu A, Bloigu R, Aalto M, Laatikainen T
Scand J Clin Lab Invest 2019 Feb-Apr;79(1-2):58-64. Epub 2019 Feb 5 doi: 10.1080/00365513.2019.1571625. PMID: 30721633
Advances in Identifying Urine/Serum Biomarkers in Alpha-1 Antitrypsin Deficiency for More Personalized Future Treatment Strategies.
Ferrarotti I, Corsico AG, Stolk J, Ottaviani S, Fumagalli M, Janciauskiene S, Iadarola P
COPD 2017 Feb;14(1):56-65. Epub 2016 Nov 9 doi: 10.1080/15412555.2016.1241760. PMID: 27827549

Recent clinical studies

Etiology

Evaluation of Laboratory Follow-up in Acne Patients Treated With Isotretinoin.
Özaslan M, Peker D
Cutis 2023 Jul;112(1):38-43. doi: 10.12788/cutis.0808. PMID: 37611311
Age-adjusted mortality and predictive value of liver chemistries in a Viennese cohort of COVID-19 patients.
Hartl L, Haslinger K, Angerer M, Jachs M, Simbrunner B, Bauer DJM, Semmler G, Scheiner B, Eigenbauer E, Strassl R, Breuer M, Kimberger O, Laxar D, Trauner M, Mandorfer M, Reiberger T
Liver Int 2022 Jun;42(6):1297-1307. Epub 2022 May 5 doi: 10.1111/liv.15274. PMID: 35412018Free PMC Article
Analysis of gamma-glutamyltransferase in acute promyelocytic leukemia patients undergoing arsenic trioxide treatment.
Sui M, Wei H, Zhang Q, Xiu R, Shen X, Zhang Z, Zhou J
Hematology 2021 Dec;26(1):58-64. doi: 10.1080/16078454.2020.1868782. PMID: 33402059
Implications of abnormal liver function in pregnancy and non-alcoholic fatty liver disease.
Lao TT
Best Pract Res Clin Obstet Gynaecol 2020 Oct;68:2-11. Epub 2020 Mar 7 doi: 10.1016/j.bpobgyn.2020.02.011. PMID: 32312689
Clinical Features of COVID-19-Related Liver Functional Abnormality.
Fan Z, Chen L, Li J, Cheng X, Yang J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J
Clin Gastroenterol Hepatol 2020 Jun;18(7):1561-1566. Epub 2020 Apr 10 doi: 10.1016/j.cgh.2020.04.002. PMID: 32283325Free PMC Article

Diagnosis

Diagnostic values of plasma matrix metalloproteinase-7, interleukin-8, and gamma-glutamyl transferase in biliary atresia.
Wu B, Zhou Y, Tian X, Cai W, Xiao Y
Eur J Pediatr 2022 Nov;181(11):3945-3953. Epub 2022 Sep 12 doi: 10.1007/s00431-022-04612-7. PMID: 36094664
Characteristics of peripheral blood Gamma-glutamyl transferase in different liver diseases.
Xing M, Gao M, Li J, Han P, Mei L, Zhao L
Medicine (Baltimore) 2022 Jan 7;101(1):e28443. doi: 10.1097/MD.0000000000028443. PMID: 35029891Free PMC Article
COVID-19 and liver injury: a meta-analysis.
Wijarnpreecha K, Ungprasert P, Panjawatanan P, Harnois DM, Zaver HB, Ahmed A, Kim D
Eur J Gastroenterol Hepatol 2021 Jul 1;33(7):990-995. doi: 10.1097/MEG.0000000000001817. PMID: 32639420Free PMC Article
An ultrasensitive bioluminogenic probe of γ-Glutamyltranspeptidase in vivo and in human serum for tumor diagnosis.
Li S, Hu R, Yang C, Zhang X, Zeng Y, Wang S, Guo X, Li Y, Cai X, Li S, Han C, Yang G
Biosens Bioelectron 2017 Dec 15;98:325-329. Epub 2017 Jun 28 doi: 10.1016/j.bios.2017.06.059. PMID: 28697445
Liver enzyme alteration: a guide for clinicians.
Giannini EG, Testa R, Savarino V
CMAJ 2005 Feb 1;172(3):367-79. doi: 10.1503/cmaj.1040752. PMID: 15684121Free PMC Article

Therapy

Evaluation of Laboratory Follow-up in Acne Patients Treated With Isotretinoin.
Özaslan M, Peker D
Cutis 2023 Jul;112(1):38-43. doi: 10.12788/cutis.0808. PMID: 37611311
Analysis of gamma-glutamyltransferase in acute promyelocytic leukemia patients undergoing arsenic trioxide treatment.
Sui M, Wei H, Zhang Q, Xiu R, Shen X, Zhang Z, Zhou J
Hematology 2021 Dec;26(1):58-64. doi: 10.1080/16078454.2020.1868782. PMID: 33402059
Clinical Features of COVID-19-Related Liver Functional Abnormality.
Fan Z, Chen L, Li J, Cheng X, Yang J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J
Clin Gastroenterol Hepatol 2020 Jun;18(7):1561-1566. Epub 2020 Apr 10 doi: 10.1016/j.cgh.2020.04.002. PMID: 32283325Free PMC Article
Peripheral hemorheological and vascular correlates of coronary blood flow.
Damaske A, Muxel S, Fasola F, Radmacher MC, Schaefer S, Jabs A, Orphal D, Wild P, Parker JD, Fineschi M, Munzel T, Forconi S, Gori T
Clin Hemorheol Microcirc 2011;49(1-4):261-9. doi: 10.3233/CH-2011-1476. PMID: 22214697
Pitavastatin: clinical effects from the LIVES Study.
Teramoto T
Atheroscler Suppl 2011 Nov;12(3):285-8. doi: 10.1016/S1567-5688(11)70888-1. PMID: 22152283

Prognosis

Evaluation of Laboratory Follow-up in Acne Patients Treated With Isotretinoin.
Özaslan M, Peker D
Cutis 2023 Jul;112(1):38-43. doi: 10.12788/cutis.0808. PMID: 37611311
Age-adjusted mortality and predictive value of liver chemistries in a Viennese cohort of COVID-19 patients.
Hartl L, Haslinger K, Angerer M, Jachs M, Simbrunner B, Bauer DJM, Semmler G, Scheiner B, Eigenbauer E, Strassl R, Breuer M, Kimberger O, Laxar D, Trauner M, Mandorfer M, Reiberger T
Liver Int 2022 Jun;42(6):1297-1307. Epub 2022 May 5 doi: 10.1111/liv.15274. PMID: 35412018Free PMC Article
Characteristics of peripheral blood Gamma-glutamyl transferase in different liver diseases.
Xing M, Gao M, Li J, Han P, Mei L, Zhao L
Medicine (Baltimore) 2022 Jan 7;101(1):e28443. doi: 10.1097/MD.0000000000028443. PMID: 35029891Free PMC Article
Clinical Features of COVID-19-Related Liver Functional Abnormality.
Fan Z, Chen L, Li J, Cheng X, Yang J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J
Clin Gastroenterol Hepatol 2020 Jun;18(7):1561-1566. Epub 2020 Apr 10 doi: 10.1016/j.cgh.2020.04.002. PMID: 32283325Free PMC Article
Pitavastatin: clinical effects from the LIVES Study.
Teramoto T
Atheroscler Suppl 2011 Nov;12(3):285-8. doi: 10.1016/S1567-5688(11)70888-1. PMID: 22152283

Clinical prediction guides

Age-adjusted mortality and predictive value of liver chemistries in a Viennese cohort of COVID-19 patients.
Hartl L, Haslinger K, Angerer M, Jachs M, Simbrunner B, Bauer DJM, Semmler G, Scheiner B, Eigenbauer E, Strassl R, Breuer M, Kimberger O, Laxar D, Trauner M, Mandorfer M, Reiberger T
Liver Int 2022 Jun;42(6):1297-1307. Epub 2022 May 5 doi: 10.1111/liv.15274. PMID: 35412018Free PMC Article
Characteristics of peripheral blood Gamma-glutamyl transferase in different liver diseases.
Xing M, Gao M, Li J, Han P, Mei L, Zhao L
Medicine (Baltimore) 2022 Jan 7;101(1):e28443. doi: 10.1097/MD.0000000000028443. PMID: 35029891Free PMC Article
Evaluation of inflammatory parameters in patients with hepatic hydatid disease.
Fan Z, Hu Y, Wang L, Jiang H, Li D, Zhao H, Wang Z
Ann Med 2021 Dec;53(1):1370-1376. doi: 10.1080/07853890.2021.1966084. PMID: 34405745Free PMC Article
Analysis of gamma-glutamyltransferase in acute promyelocytic leukemia patients undergoing arsenic trioxide treatment.
Sui M, Wei H, Zhang Q, Xiu R, Shen X, Zhang Z, Zhou J
Hematology 2021 Dec;26(1):58-64. doi: 10.1080/16078454.2020.1868782. PMID: 33402059
Pitavastatin: clinical effects from the LIVES Study.
Teramoto T
Atheroscler Suppl 2011 Nov;12(3):285-8. doi: 10.1016/S1567-5688(11)70888-1. PMID: 22152283

Recent systematic reviews

Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
Eslami L, Merat S, Malekzadeh R, Nasseri-Moghaddam S, Aramin H
Cochrane Database Syst Rev 2013 Dec 27;(12):CD008623. doi: 10.1002/14651858.CD008623.pub2. PMID: 24374462

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