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Mitral chordae tendinae rupture

MedGen UID:
1842037
•Concept ID:
C5826383
•
Disease or Syndrome
HPO: HP:0034419

Definition

Breakage of the chordae tendinae of the mitral valve. This can lead to loss of tension of one of the mitral valve leaflets and mitral regurgitation. [from HPO]

Professional guidelines

PubMed

Assessment and Management of Acute Severe Mitral Regurgitation in the Intensive Care Unit.
Leitman M, Tyomkin V, Raanani E, Sharony R, Tzatskin L, Peleg E, Blatt A, Vered Z
J Heart Valve Dis 2017 Mar;26(2):161-168. PMID: 28820545
The systolic click-murmur syndrome: clinical recognition and management.
O'rourke RA, Crawford MH
Curr Probl Cardiol 1976 Mar-Apr;1(1):1-60. doi: 10.1016/s0146-2806(76)80006-0. PMID: 1017208
Etiology and differential diagnosis of acute mitral regurgitation.
Sanders CA, Armstrong PW, Willerson JT, Dinsmore RE
Prog Cardiovasc Dis 1971 Sep;14(2):129-52. doi: 10.1016/0033-0620(71)90051-x. PMID: 4256649

Recent clinical studies

Etiology

Matrix metalloproteinase-1 mitral expression and -1607 1G/2G gene promoter polymorphism in mitral chordae tendinae rupture.
Lin TH, Yang SF, Chiu CC, Su HM, Wang CL, Voon WC, Lai WT, Sheu SH
Transl Res 2013 May;161(5):406-13. Epub 2012 Oct 29 doi: 10.1016/j.trsl.2012.10.002. PMID: 23116893
Synergistic effect of mitral expression of tissue inhibitor of metalloproteinase-2 with hypertension on the occurrence of mitral chordae tendinae rupture.
Lin TH, Yang SF, Chiu CC, Lee YT, Su HM, Voon WC, Lai WT, Sheu SH
J Hypertens 2009 Oct;27(10):2079-85. doi: 10.1097/HJH.0b013e32832f50d8. PMID: 19727008
Association between hypertension and primary mitral chordae tendinae rupture.
Lin TH, Su HM, Voon WC, Lai HM, Yen HW, Lai WT, Sheu SH
Am J Hypertens 2006 Jan;19(1):75-9. doi: 10.1016/j.amjhyper.2005.06.020. PMID: 16461195

Therapy

A pig model of ischemic mitral regurgitation induced by mitral chordae tendinae rupture and implantation of an ameroid constrictor.
Cui YC, Li K, Tian Y, Yuan WM, Peng P, Yang JZ, Zhang BJ, Zhang HD, Wu AL, Tang Y
PLoS One 2014;9(12):e111689. Epub 2014 Dec 5 doi: 10.1371/journal.pone.0111689. PMID: 25479001Free PMC Article

Prognosis

Association between hypertension and primary mitral chordae tendinae rupture.
Lin TH, Su HM, Voon WC, Lai HM, Yen HW, Lai WT, Sheu SH
Am J Hypertens 2006 Jan;19(1):75-9. doi: 10.1016/j.amjhyper.2005.06.020. PMID: 16461195

Clinical prediction guides

A pig model of ischemic mitral regurgitation induced by mitral chordae tendinae rupture and implantation of an ameroid constrictor.
Cui YC, Li K, Tian Y, Yuan WM, Peng P, Yang JZ, Zhang BJ, Zhang HD, Wu AL, Tang Y
PLoS One 2014;9(12):e111689. Epub 2014 Dec 5 doi: 10.1371/journal.pone.0111689. PMID: 25479001Free PMC Article
Association between hypertension and primary mitral chordae tendinae rupture.
Lin TH, Su HM, Voon WC, Lai HM, Yen HW, Lai WT, Sheu SH
Am J Hypertens 2006 Jan;19(1):75-9. doi: 10.1016/j.amjhyper.2005.06.020. PMID: 16461195

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