U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Focal necrotic brainstem lesion

MedGen UID:
1842052
•Concept ID:
C5826813
•
Finding
HPO: HP:0034986

Definition

A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the brainstem. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal necrotic brainstem lesion

Professional guidelines

PubMed

Space-occupying cerebellar infarction: complications, treatment, and outcome.
Neugebauer H, Witsch J, Zweckberger K, Jüttler E
Neurosurg Focus 2013 May;34(5):E8. doi: 10.3171/2013.2.FOCUS12363. PMID: 23634927
Percheron artery syndrome: variability in presentation and differential diagnosis.
de la Cruz-Cosme C, Márquez-Martínez M, Aguilar-Cuevas R, Romero-Acebal M, Valdivielso-Felices P
Rev Neurol 2011 Aug 16;53(4):193-200. PMID: 21780071
Treatment of central nervous system involvement associated with primary Sjögren's syndrome.
Ozgocmen S, Gur A
Curr Pharm Des 2008;14(13):1270-3. doi: 10.2174/138161208799316366. PMID: 18537651

Recent clinical studies

Etiology

Improved detectability of acute and subacute brainstem infarctions by combining standard axial and thin-sliced sagittal DWI.
Schönfeld MH, Ritzel RM, Kemmling A, Ernst M, Fiehler J, Gellißen S
PLoS One 2018;13(7):e0200092. Epub 2018 Jul 3 doi: 10.1371/journal.pone.0200092. PMID: 29969485Free PMC Article
Stem cell transplantation for ischemic stroke.
Boncoraglio GB, Bersano A, Candelise L, Reynolds BA, Parati EA
Cochrane Database Syst Rev 2010 Sep 8;(9):CD007231. doi: 10.1002/14651858.CD007231.pub2. PMID: 20824857
Prenatal stroke.
Govaert P
Semin Fetal Neonatal Med 2009 Oct;14(5):250-66. Epub 2009 Aug 6 doi: 10.1016/j.siny.2009.07.008. PMID: 19664975
Brainstem reflex circuits revisited.
Cruccu G, Iannetti GD, Marx JJ, Thoemke F, Truini A, Fitzek S, Galeotti F, Urban PP, Romaniello A, Stoeter P, Manfredi M, Hopf HC
Brain 2005 Feb;128(Pt 2):386-94. Epub 2004 Dec 15 doi: 10.1093/brain/awh366. PMID: 15601661
MRI characteristics of acute and subacute brainstem and thalamic infarctions: value of T2- and diffusion-weighted sequences.
Küker W, Weise J, Krapf H, Schmidt F, Friese S, Bähr M
J Neurol 2002 Jan;249(1):33-42. doi: 10.1007/pl00007845. PMID: 11954866

Diagnosis

Ependymoma Presenting as a -Rim-Enhancing Lesion in the Brainstem.
Malbari F, Aldave G, Birchansky SB, Paulino AC, Lopez-Terrada DH, Mohila CA, Zhao S, Chintagumpala M
Pediatr Neurosurg 2021;56(5):455-459. Epub 2021 Jun 18 doi: 10.1159/000516001. PMID: 34148044
Improved detectability of acute and subacute brainstem infarctions by combining standard axial and thin-sliced sagittal DWI.
Schönfeld MH, Ritzel RM, Kemmling A, Ernst M, Fiehler J, Gellißen S
PLoS One 2018;13(7):e0200092. Epub 2018 Jul 3 doi: 10.1371/journal.pone.0200092. PMID: 29969485Free PMC Article
Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL).
Stojanov D, Vojinovic S, Aracki-Trenkic A, Tasic A, Benedeto-Stojanov D, Ljubisavljevic S, Vujnovic S
Bosn J Basic Med Sci 2015 Feb 9;15(1):1-8. doi: 10.17305/bjbms.2015.247. PMID: 25725137Free PMC Article
Prenatal stroke.
Govaert P
Semin Fetal Neonatal Med 2009 Oct;14(5):250-66. Epub 2009 Aug 6 doi: 10.1016/j.siny.2009.07.008. PMID: 19664975
Brainstem reflex circuits revisited.
Cruccu G, Iannetti GD, Marx JJ, Thoemke F, Truini A, Fitzek S, Galeotti F, Urban PP, Romaniello A, Stoeter P, Manfredi M, Hopf HC
Brain 2005 Feb;128(Pt 2):386-94. Epub 2004 Dec 15 doi: 10.1093/brain/awh366. PMID: 15601661

Therapy

CO(2)-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death.
Jaster JH, Zamecnik J, Giannì AB, Ottaviani G
Cardiovasc Pathol 2019 Jan-Feb;38:42-45. Epub 2018 Oct 26 doi: 10.1016/j.carpath.2018.10.009. PMID: 30466068
Stem cell transplantation for ischemic stroke.
Boncoraglio GB, Bersano A, Candelise L, Reynolds BA, Parati EA
Cochrane Database Syst Rev 2010 Sep 8;(9):CD007231. doi: 10.1002/14651858.CD007231.pub2. PMID: 20824857
Treatment of central nervous system involvement associated with primary Sjögren's syndrome.
Ozgocmen S, Gur A
Curr Pharm Des 2008;14(13):1270-3. doi: 10.2174/138161208799316366. PMID: 18537651
Emerging concepts in periventricular white matter injury.
Back SA, Rivkees SA
Semin Perinatol 2004 Dec;28(6):405-14. doi: 10.1053/j.semperi.2004.10.010. PMID: 15693397
Environmental influence on recovery after brain lesions--experimental and clinical data.
Johansson BB
J Rehabil Med 2003 May;(41 Suppl):11-6. doi: 10.1080/16501960310010089. PMID: 12817651

Prognosis

Intracranial melanotic schwannomas: a rare variant with unusual adherent features.
Mahato D, Vivas-Buitrago T, Gassie K, Jentoft M, Tavanaiepour D, Quiñones-Hinojosa A
J Neurooncol 2018 Jan;136(2):299-306. Epub 2017 Nov 2 doi: 10.1007/s11060-017-2653-z. PMID: 29098570
Molecular pathogenesis of polymerase γ-related neurodegeneration.
Tzoulis C, Tran GT, Coxhead J, Bertelsen B, Lilleng PK, Balafkan N, Payne B, Miletic H, Chinnery PF, Bindoff LA
Ann Neurol 2014 Jul;76(1):66-81. Epub 2014 Jun 14 doi: 10.1002/ana.24185. PMID: 24841123Free PMC Article
Space-occupying cerebellar infarction: complications, treatment, and outcome.
Neugebauer H, Witsch J, Zweckberger K, Jüttler E
Neurosurg Focus 2013 May;34(5):E8. doi: 10.3171/2013.2.FOCUS12363. PMID: 23634927
The use of motor evoked potential monitoring during cerebral aneurysm surgery to predict pure motor deficits due to subcortical ischemia.
Guo L, Gelb AW
Clin Neurophysiol 2011 Apr;122(4):648-55. doi: 10.1016/j.clinph.2010.09.001. PMID: 20869304
Neuro-Behçet's disease.
Hadfield MG, Aydin F, Lippman HR, Sanders KM
Clin Neuropathol 1997 Mar-Apr;16(2):55-60. PMID: 9101104

Clinical prediction guides

Clinical and Radiological Characteristics Associated with Respiratory Failure in Unilateral Lateral Medullary Infarction.
Pavšič K, Fabjan A, Zgonc V, Šurlan Popović K, Pretnar Oblak J, Bajrović FF
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105947. Epub 2021 Jun 27 doi: 10.1016/j.jstrokecerebrovasdis.2021.105947. PMID: 34192618
Focal brainstem infarction in the adult rat.
Namioka A, Namioka T, Sasaki M, Kocsis JD, Honmou O
Lab Anim (NY) 2021 Apr;50(4):97-107. Epub 2021 Feb 9 doi: 10.1038/s41684-021-00722-1. PMID: 33564191
Improved detectability of acute and subacute brainstem infarctions by combining standard axial and thin-sliced sagittal DWI.
Schönfeld MH, Ritzel RM, Kemmling A, Ernst M, Fiehler J, Gellißen S
PLoS One 2018;13(7):e0200092. Epub 2018 Jul 3 doi: 10.1371/journal.pone.0200092. PMID: 29969485Free PMC Article
Space-occupying cerebellar infarction: complications, treatment, and outcome.
Neugebauer H, Witsch J, Zweckberger K, Jüttler E
Neurosurg Focus 2013 May;34(5):E8. doi: 10.3171/2013.2.FOCUS12363. PMID: 23634927
The use of motor evoked potential monitoring during cerebral aneurysm surgery to predict pure motor deficits due to subcortical ischemia.
Guo L, Gelb AW
Clin Neurophysiol 2011 Apr;122(4):648-55. doi: 10.1016/j.clinph.2010.09.001. PMID: 20869304

Recent systematic reviews

Stem cell transplantation for ischemic stroke.
Boncoraglio GB, Bersano A, Candelise L, Reynolds BA, Parati EA
Cochrane Database Syst Rev 2010 Sep 8;(9):CD007231. doi: 10.1002/14651858.CD007231.pub2. PMID: 20824857

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...