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Abnormal liver enzyme activity or concentration

MedGen UID:
1842083
•Concept ID:
C5826587
•
Finding
Synonym: Abnormal hepatic enzyme activity or concentration
 
HPO: HP:0034685

Definition

Concentration or activity of an enzyme is above or below the limits of normal in liver tissue. [from HPO]

Professional guidelines

PubMed

Continuous glucose monitoring and metrics for clinical trials: an international consensus statement.
Battelino T, Alexander CM, Amiel SA, Arreaza-Rubin G, Beck RW, Bergenstal RM, Buckingham BA, Carroll J, Ceriello A, Chow E, Choudhary P, Close K, Danne T, Dutta S, Gabbay R, Garg S, Heverly J, Hirsch IB, Kader T, Kenney J, Kovatchev B, Laffel L, Maahs D, Mathieu C, Mauricio D, Nimri R, Nishimura R, Scharf M, Del Prato S, Renard E, Rosenstock J, Saboo B, Ueki K, Umpierrez GE, Weinzimer SA, Phillip M
Lancet Diabetes Endocrinol 2023 Jan;11(1):42-57. Epub 2022 Dec 6 doi: 10.1016/S2213-8587(22)00319-9. PMID: 36493795
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL
Eur Heart J 2022 Oct 14;43(39):3925-3946. doi: 10.1093/eurheartj/ehac361. PMID: 36036785Free PMC Article
Clinical practice guideline on diagnosis and treatment of hyponatraemia.
Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, van der Veer S, Van Biesen W, Nagler E; Hyponatraemia Guideline Development Group
Eur J Endocrinol 2014 Mar;170(3):G1-47. Epub 2014 Feb 25 doi: 10.1530/EJE-13-1020. PMID: 24569125

Recent clinical studies

Etiology

International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
The interplay between thyroid and liver: implications for clinical practice.
Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML
J Endocrinol Invest 2020 Jul;43(7):885-899. Epub 2020 Mar 12 doi: 10.1007/s40618-020-01208-6. PMID: 32166702
Statins and Abnormal Liver Enzymes.
Shrestha A, Mulmi A, Munankarmi R
S D Med 2019 Jan;72(1):12-14. PMID: 30849222
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE
J Am Soc Nephrol 2018 Oct;29(10):2458-2470. Epub 2018 Sep 18 doi: 10.1681/ASN.2018060590. PMID: 30228150Free PMC Article
Adverse effects of creatine supplementation: fact or fiction?
Poortmans JR, Francaux M
Sports Med 2000 Sep;30(3):155-70. doi: 10.2165/00007256-200030030-00002. PMID: 10999421

Diagnosis

Approach to Elevated Liver Enzymes.
Rosenberg J, Sola O, Visconti A
Prim Care 2023 Sep;50(3):363-376. Epub 2023 May 16 doi: 10.1016/j.pop.2023.03.007. PMID: 37516508
International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
Abnormal Liver Enzymes.
Melendez-Rosado J, Alsaad A, Stancampiano FF, Palmer WC
Gastroenterol Nurs 2018 Nov/Dec;41(6):497-507. doi: 10.1097/SGA.0000000000000346. PMID: 30418344
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE
J Am Soc Nephrol 2018 Oct;29(10):2458-2470. Epub 2018 Sep 18 doi: 10.1681/ASN.2018060590. PMID: 30228150Free PMC Article
Liver enzyme alteration: a guide for clinicians.
Giannini EG, Testa R, Savarino V
CMAJ 2005 Feb 1;172(3):367-79. doi: 10.1503/cmaj.1040752. PMID: 15684121Free PMC Article

Therapy

Statins and Abnormal Liver Enzymes.
Shrestha A, Mulmi A, Munankarmi R
S D Med 2019 Jan;72(1):12-14. PMID: 30849222
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE
J Am Soc Nephrol 2018 Oct;29(10):2458-2470. Epub 2018 Sep 18 doi: 10.1681/ASN.2018060590. PMID: 30228150Free PMC Article
Ursodeoxycholic acid for cystic fibrosis-related liver disease.
Cheng K, Ashby D, Smyth RL
Cochrane Database Syst Rev 2017 Sep 11;9(9):CD000222. doi: 10.1002/14651858.CD000222.pub4. PMID: 28891588Free PMC Article
Adverse effects of creatine supplementation: fact or fiction?
Poortmans JR, Francaux M
Sports Med 2000 Sep;30(3):155-70. doi: 10.2165/00007256-200030030-00002. PMID: 10999421
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Prognosis

Nonalcoholic Fatty Liver Disease Incidence and Remission and Their Predictors During 7 Years of Follow-up Among Finns.
Korpimäki S, Rovio SP, Juonala M, Hutri-Kähönen N, Lehtimäki T, Laitinen TP, Tossavainen P, Jokinen E, Loo BM, Männistö S, Tammelin T, Haarala A, Aatola H, Komar G, Viikari J, Raitakari O, Kähönen M, Pahkala K
J Clin Endocrinol Metab 2023 Dec 21;109(1):e291-e305. doi: 10.1210/clinem/dgad418. PMID: 37463486Free PMC Article
Thyroid Storm: A Japanese Perspective.
Akamizu T
Thyroid 2018 Jan;28(1):32-40. Epub 2017 Oct 5 doi: 10.1089/thy.2017.0243. PMID: 28899229Free PMC Article
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
McGovern MM, Avetisyan R, Sanson BJ, Lidove O
Orphanet J Rare Dis 2017 Feb 23;12(1):41. doi: 10.1186/s13023-017-0572-x. PMID: 28228103Free PMC Article
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588
Neonatal adrenoleukodystrophy.
Aubourg P, Scotto J, Rocchiccioli F, Feldmann-Pautrat D, Robain O
J Neurol Neurosurg Psychiatry 1986 Jan;49(1):77-86. doi: 10.1136/jnnp.49.1.77. PMID: 2420940Free PMC Article

Clinical prediction guides

The interplay between thyroid and liver: implications for clinical practice.
Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML
J Endocrinol Invest 2020 Jul;43(7):885-899. Epub 2020 Mar 12 doi: 10.1007/s40618-020-01208-6. PMID: 32166702
A critical appraisal of one-stage and chromogenic assays of factor VIII activity.
Peyvandi F, Oldenburg J, Friedman KD
J Thromb Haemost 2016 Feb;14(2):248-61. Epub 2016 Feb 1 doi: 10.1111/jth.13215. PMID: 26663865
Liver involvement in Turner syndrome.
Roulot D
Liver Int 2013 Jan;33(1):24-30. Epub 2012 Nov 1 doi: 10.1111/liv.12007. PMID: 23121401
Part I: Liver function in oncology: biochemistry and beyond.
Field KM, Dow C, Michael M
Lancet Oncol 2008 Nov;9(11):1092-101. doi: 10.1016/S1470-2045(08)70279-1. PMID: 19012858
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Recent systematic reviews

Patients With Knee Osteoarthritis Who Receive Platelet-Rich Plasma or Bone Marrow Aspirate Concentrate Injections Have Better Outcomes Than Patients Who Receive Hyaluronic Acid: Systematic Review and Meta-analysis.
Belk JW, Lim JJ, Keeter C, McCulloch PC, Houck DA, McCarty EC, Frank RM, Kraeutler MJ
Arthroscopy 2023 Jul;39(7):1714-1734. Epub 2023 Mar 11 doi: 10.1016/j.arthro.2023.03.001. PMID: 36913992
Dimensional and histomorphometric evaluation of biomaterials used for alveolar ridge preservation: a systematic review and network meta-analysis.
Canullo L, Del Fabbro M, Khijmatgar S, Panda S, Ravidà A, Tommasato G, Sculean A, Pesce P
Clin Oral Investig 2022 Jan;26(1):141-158. Epub 2021 Nov 26 doi: 10.1007/s00784-021-04248-1. PMID: 34826029
Risk factors for postpartum depression: An evidence-based systematic review of systematic reviews and meta-analyses.
Zhao XH, Zhang ZH
Asian J Psychiatr 2020 Oct;53:102353. Epub 2020 Aug 30 doi: 10.1016/j.ajp.2020.102353. PMID: 32927309
Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review.
Solderer A, Kaufmann M, Hofer D, Wiedemeier D, Attin T, Schmidlin PR
Clin Oral Investig 2019 Jan;23(1):21-32. Epub 2018 Dec 7 doi: 10.1007/s00784-018-2761-y. PMID: 30535817
Lithium toxicity profile: a systematic review and meta-analysis.
McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR
Lancet 2012 Feb 25;379(9817):721-8. Epub 2012 Jan 20 doi: 10.1016/S0140-6736(11)61516-X. PMID: 22265699

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