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Elevated circulating homoarginine concentration

MedGen UID:
1842096
•Concept ID:
C5826630
•
Finding
Synonym: Homoarginine high in blood
 
HPO: HP:0034741

Definition

Concentration of homoarginine in the blood circulation above the upper limit of normal. [from HPO]

Recent clinical studies

Etiology

Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection.
Bollenbach A, Hanff E, Brunner G, Tsikas D
Amino Acids 2019 Jun;51(6):961-971. Epub 2019 Apr 26 doi: 10.1007/s00726-019-02737-y. PMID: 31028565
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes.
Tsikas D, Bollenbach A, Hanff E, Kayacelebi AA
Cardiovasc Diabetol 2018 Jan 4;17(1):1. doi: 10.1186/s12933-017-0656-x. PMID: 29301528Free PMC Article
Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood.
Langen J, Kayacelebi AA, Beckmann B, Weigt-Usinger K, Carmann C, Hörster I, Lilienthal E, Richter-Unruh A, Tsikas D, Lücke T
Amino Acids 2015 Sep;47(9):1875-83. Epub 2015 Jun 28 doi: 10.1007/s00726-015-2028-8. PMID: 26123987
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
Kayacelebi AA, Willers J, Pham VV, Hahn A, Schneider JY, Rothmann S, Frölich JC, Tsikas D
Amino Acids 2015 Sep;47(9):1885-91. Epub 2015 Jan 25 doi: 10.1007/s00726-015-1915-3. PMID: 25618752
Serum reference intervals of homoarginine, ADMA, and SDMA in the study of health in Pomerania.
Atzler D, Schwedhelm E, Nauck M, Ittermann T, Böger RH, Friedrich N
Clin Chem Lab Med 2014 Dec;52(12):1835-42. doi: 10.1515/cclm-2014-0314. PMID: 24945429

Diagnosis

Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood.
Langen J, Kayacelebi AA, Beckmann B, Weigt-Usinger K, Carmann C, Hörster I, Lilienthal E, Richter-Unruh A, Tsikas D, Lücke T
Amino Acids 2015 Sep;47(9):1875-83. Epub 2015 Jun 28 doi: 10.1007/s00726-015-2028-8. PMID: 26123987
The L-arginine/NO pathway, homoarginine, and nitrite-dependent renal carbonic anhydrase activity in young people with type 1 diabetes mellitus.
Carmann C, Lilienthal E, Weigt-Usinger K, Schmidt-Choudhury A, Hörster I, Kayacelebi AA, Beckmann B, Chobanyan-Jürgens K, Tsikas D, Lücke T
Amino Acids 2015 Sep;47(9):1865-74. Epub 2015 Jun 28 doi: 10.1007/s00726-015-2027-9. PMID: 26123986
Serum reference intervals of homoarginine, ADMA, and SDMA in the study of health in Pomerania.
Atzler D, Schwedhelm E, Nauck M, Ittermann T, Böger RH, Friedrich N
Clin Chem Lab Med 2014 Dec;52(12):1835-42. doi: 10.1515/cclm-2014-0314. PMID: 24945429

Therapy

Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood.
Langen J, Kayacelebi AA, Beckmann B, Weigt-Usinger K, Carmann C, Hörster I, Lilienthal E, Richter-Unruh A, Tsikas D, Lücke T
Amino Acids 2015 Sep;47(9):1875-83. Epub 2015 Jun 28 doi: 10.1007/s00726-015-2028-8. PMID: 26123987
The L-arginine/NO pathway, homoarginine, and nitrite-dependent renal carbonic anhydrase activity in young people with type 1 diabetes mellitus.
Carmann C, Lilienthal E, Weigt-Usinger K, Schmidt-Choudhury A, Hörster I, Kayacelebi AA, Beckmann B, Chobanyan-Jürgens K, Tsikas D, Lücke T
Amino Acids 2015 Sep;47(9):1865-74. Epub 2015 Jun 28 doi: 10.1007/s00726-015-2027-9. PMID: 26123986
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
Kayacelebi AA, Willers J, Pham VV, Hahn A, Schneider JY, Rothmann S, Frölich JC, Tsikas D
Amino Acids 2015 Sep;47(9):1885-91. Epub 2015 Jan 25 doi: 10.1007/s00726-015-1915-3. PMID: 25618752

Clinical prediction guides

The L-arginine/NO pathway, homoarginine, and nitrite-dependent renal carbonic anhydrase activity in young people with type 1 diabetes mellitus.
Carmann C, Lilienthal E, Weigt-Usinger K, Schmidt-Choudhury A, Hörster I, Kayacelebi AA, Beckmann B, Chobanyan-Jürgens K, Tsikas D, Lücke T
Amino Acids 2015 Sep;47(9):1865-74. Epub 2015 Jun 28 doi: 10.1007/s00726-015-2027-9. PMID: 26123986

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