U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alpha granule disease

MedGen UID:
1842309
•Concept ID:
C5681720
•
Disease or Syndrome
Synonym: alpha granule disease
 
Monarch Initiative: MONDO:0020117
Orphanet: ORPHA98455

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlpha granule disease

Professional guidelines

PubMed

Ovarian cancer treatment and natural killer cell-based immunotherapy.
Fan Z, Han D, Fan X, Zhao L
Front Immunol 2023;14:1308143. Epub 2023 Dec 21 doi: 10.3389/fimmu.2023.1308143. PMID: 38187402Free PMC Article
Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis.
Makkar R, Sehgal A, Singh S, Sharma N, Rawat R, Rashid S, Vargas-De-La-Cruz C, Yadav S, Bungau SG, Behl T
Inflammopharmacology 2023 Aug;31(4):1577-1588. Epub 2023 Jun 19 doi: 10.1007/s10787-023-01262-5. PMID: 37335368
Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment.
Chong S, Wei C, Feng L, Guo R
ACS Biomater Sci Eng 2023 Jun 12;9(6):3368-3378. Epub 2023 Apr 28 doi: 10.1021/acsbiomaterials.3c00284. PMID: 37115665

Recent clinical studies

Etiology

Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.
Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, Liu W, Li G, Lu D, Meng G, Hu L, Yuan A, Lu X, Pu J
Eur Heart J 2022 Jun 21;43(24):2317-2334. doi: 10.1093/eurheartj/ehac109. PMID: 35267019Free PMC Article
Release of α-granule contents during platelet activation.
Smith CW
Platelets 2022 May 19;33(4):491-502. Epub 2021 Sep 25 doi: 10.1080/09537104.2021.1913576. PMID: 34569425
Platelet-cancer interactions.
Goubran HA, Stakiw J, Radosevic M, Burnouf T
Semin Thromb Hemost 2014 Apr;40(3):296-305. Epub 2014 Mar 3 doi: 10.1055/s-0034-1370767. PMID: 24590421
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033

Diagnosis

Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
α-granule biogenesis: from disease to discovery.
Chen CH, Lo RW, Urban D, Pluthero FG, Kahr WH
Platelets 2017 Mar;28(2):147-154. Epub 2017 Feb 22 doi: 10.1080/09537104.2017.1280599. PMID: 28277061
Chromogranin A as biomarker in diabetes.
Broedbaek K, Hilsted L
Biomark Med 2016 Nov;10(11):1181-1189. Epub 2016 Sep 9 doi: 10.2217/bmm-2016-0091. PMID: 27611656
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Therapy

The immunology of PF4 polyanion interactions.
Ngo ATP, Bochenek V, Gollomp K
Curr Opin Hematol 2023 Nov 1;30(6):219-229. Epub 2023 Aug 28 doi: 10.1097/MOH.0000000000000782. PMID: 37603711
Dimethyl fumarate possesses antiplatelet and antithrombotic properties.
Chu X, Zhang J, Li Y, Yuan K, Wang X, Gui X, Sun Y, Geng C, Ju W, Xu M, Li Z, Zeng L, Xu K, Qiao J
Int Immunopharmacol 2023 Jul;120:110381. Epub 2023 May 26 doi: 10.1016/j.intimp.2023.110381. PMID: 37245302
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.
Qi Z, Hu L, Zhang J, Yang W, Liu X, Jia D, Yao Z, Chang L, Pan G, Zhong H, Luo X, Yao K, Sun A, Qian J, Ding Z, Ge J
Circulation 2021 Jan 5;143(1):45-61. Epub 2020 Sep 29 doi: 10.1161/CIRCULATIONAHA.120.046290. PMID: 32988222
Regulation of PCSK9 by nutraceuticals.
Momtazi AA, Banach M, Pirro M, Katsiki N, Sahebkar A
Pharmacol Res 2017 Jun;120:157-169. Epub 2017 Mar 29 doi: 10.1016/j.phrs.2017.03.023. PMID: 28363723
Subcutaneous panniculitis-like T-cell lymphoma.
Tomasini D, Berti E
G Ital Dermatol Venereol 2013 Aug;148(4):395-411. PMID: 23900161

Prognosis

Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Platelets in the NETworks interweaving inflammation and thrombosis.
Wienkamp AK, Erpenbeck L, Rossaint J
Front Immunol 2022;13:953129. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.953129. PMID: 35979369Free PMC Article
Release of α-granule contents during platelet activation.
Smith CW
Platelets 2022 May 19;33(4):491-502. Epub 2021 Sep 25 doi: 10.1080/09537104.2021.1913576. PMID: 34569425
Subcutaneous panniculitis-like T-cell lymphoma.
Tomasini D, Berti E
G Ital Dermatol Venereol 2013 Aug;148(4):395-411. PMID: 23900161
Pancreatoblastoma.
Chun Y, Kim W, Park K, Lee S, Jung S
J Pediatr Surg 1997 Nov;32(11):1612-5. doi: 10.1016/s0022-3468(97)90465-6. PMID: 9396538

Clinical prediction guides

Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis.
Meng Z, Zhang S, Li W, Wang Y, Wang M, Liu X, Liu CL, Liao S, Liu T, Yang C, Lindholt JS, Rasmussen LM, Obel LM, Stubbe J, Diederichsen AC, Sun Y, Chen Y, Yu PB, Libby P, Shi GP, Guo J
Eur Heart J 2023 Aug 1;44(29):2763-2783. doi: 10.1093/eurheartj/ehad262. PMID: 37279475Free PMC Article
Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease.
Zhang X, Chao P, Zhang L, Xu L, Cui X, Wang S, Wusiman M, Jiang H, Lu C
Front Immunol 2023;14:1030198. Epub 2023 Mar 29 doi: 10.3389/fimmu.2023.1030198. PMID: 37063851Free PMC Article
Alpha-Synuclein and Its Role in Melanocytes.
Rachinger N, Mittag N, Böhme-Schäfer I, Xiang W, Kuphal S, Bosserhoff AK
Cells 2022 Jun 30;11(13) doi: 10.3390/cells11132087. PMID: 35805172Free PMC Article
Release of α-granule contents during platelet activation.
Smith CW
Platelets 2022 May 19;33(4):491-502. Epub 2021 Sep 25 doi: 10.1080/09537104.2021.1913576. PMID: 34569425
The early history of the eosinophil.
Kay AB
Clin Exp Allergy 2015 Mar;45(3):575-82. doi: 10.1111/cea.12480. PMID: 25544991

Recent systematic reviews

Uterine wound healing after caesarean section: A systematic review.
Debras E, Capmas P, Maudot C, Chavatte-Palmer P
Eur J Obstet Gynecol Reprod Biol 2024 May;296:83-90. Epub 2024 Feb 27 doi: 10.1016/j.ejogrb.2024.02.045. PMID: 38417279
Adverse reactions of Niaoduqing granules: A systematic review and meta-analysis.
Fu B, Shang Z, Song S, Xu Y, Wei L, Li G, Yang H
Phytomedicine 2023 Jan;109:154535. Epub 2022 Nov 9 doi: 10.1016/j.phymed.2022.154535. PMID: 36610168
Effects of Uremic Clearance Granules in Uremic Pruritus: A Meta-Analysis.
Lu PH, Wang JY, Chuo HE, Lu PH
Toxins (Basel) 2021 Oct 4;13(10) doi: 10.3390/toxins13100702. PMID: 34678995Free PMC Article
Effect of resistant starch type 2 on inflammatory mediators: A systematic review and meta-analysis of randomized controlled trials.
Haghighatdoost F, Gholami A, Hariri M
Complement Ther Med 2021 Jan;56:102597. Epub 2020 Oct 24 doi: 10.1016/j.ctim.2020.102597. PMID: 33197672
Platelet rich plasma: a valid augmentation for cartilage scaffolds? A systematic review.
Perdisa F, Filardo G, Di Matteo B, Marcacci M, Kon E
Histol Histopathol 2014 Jul;29(7):805-14. Epub 2014 Jan 24 doi: 10.14670/HH-29.805. PMID: 24458849

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...