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Acute disseminated encephalomyelitis with anti-MOG antibodies

MedGen UID:
1842363
•Concept ID:
C5680301
•
Disease or Syndrome
Synonyms: acute disseminated encephalomyelitis with anti-MOG antibodies; Acute disseminated encephalomyelitis with anti-myelin oligodendrocyte glycoprotein antibodies; ADEM with anti-MOG antibodies
 
Monarch Initiative: MONDO:0035669
Orphanet: ORPHA592894

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute disseminated encephalomyelitis with anti-MOG antibodies

Professional guidelines

PubMed

Pathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.
Tanaka K, Kezuka T, Ishikawa H, Tanaka M, Sakimura K, Abe M, Kawamura M
Int J Mol Sci 2023 Aug 29;24(17) doi: 10.3390/ijms241713368. PMID: 37686172Free PMC Article
Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome.
Wong YYM, Hacohen Y, Armangue T, Wassmer E, Verhelst H, Hemingway C, van Pelt ED, Catsman-Berrevoets CE, Hintzen RQ, Deiva K, Lim MJ, Rostásy K, Neuteboom RF
Eur J Neurol 2018 May;25(5):782-786. Epub 2018 Mar 9 doi: 10.1111/ene.13602. PMID: 29443442

Recent clinical studies

Etiology

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.
Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780
Myelin Oligodendrocyte Glycoprotein-Associated Disorders.
Longbrake E
Continuum (Minneap Minn) 2022 Aug 1;28(4):1171-1193. doi: 10.1212/CON.0000000000001127. PMID: 35938661Free PMC Article
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Rempe T, Tarhan B, Rodriguez E, Viswanathan VT, Gyang TV, Carlson A, Tuna IS, Rees J
Mult Scler Relat Disord 2021 Feb;48:102718. Epub 2020 Dec 24 doi: 10.1016/j.msard.2020.102718. PMID: 33388560
Seropositive anti-MOG antibody-associated acute disseminated encephalomyelitis (ADEM): a sequelae of Mycoplasma pneumoniae infection.
Bonagiri P, Park D, Ingebritsen J, Christie LJ
BMJ Case Rep 2020 May 19;13(5) doi: 10.1136/bcr-2020-234565. PMID: 32434879Free PMC Article
The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults.
de Mol CL, Wong Y, van Pelt ED, Wokke B, Siepman T, Neuteboom RF, Hamann D, Hintzen RQ
Mult Scler 2020 Jun;26(7):806-814. Epub 2019 May 16 doi: 10.1177/1352458519845112. PMID: 31094288Free PMC Article

Diagnosis

Myelin Oligodendrocyte Glycoprotein-Associated Disorders.
Longbrake E
Continuum (Minneap Minn) 2022 Aug 1;28(4):1171-1193. doi: 10.1212/CON.0000000000001127. PMID: 35938661Free PMC Article
Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Rempe T, Tarhan B, Rodriguez E, Viswanathan VT, Gyang TV, Carlson A, Tuna IS, Rees J
Mult Scler Relat Disord 2021 Feb;48:102718. Epub 2020 Dec 24 doi: 10.1016/j.msard.2020.102718. PMID: 33388560
MOG antibody-associated encephalomyelitis/encephalitis.
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.
Ramanathan S, Dale RC, Brilot F
Autoimmun Rev 2016 Apr;15(4):307-24. Epub 2015 Dec 17 doi: 10.1016/j.autrev.2015.12.004. PMID: 26708342

Therapy

A case of bilateral limbic and recurrent unilateral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein antibody positivity.
Horita T, Inoue T, Kuki I, Nagase S, Yamamoto N, Yamada N, Oki K, Nukui M, Okazaki S, Amo K, Kawawaki H, Sakuma H, Togawa M
Brain Dev 2022 Mar;44(3):254-258. Epub 2021 Nov 18 doi: 10.1016/j.braindev.2021.10.011. PMID: 34802814
Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article
Acute Disseminated Encephalomyelitis (ADEM) and Increased Intracranial Pressure Associated With Anti-Myelin Oligodendrocyte Glycoprotein Antibodies.
Narayan RN, Wang C, Greenberg BM
Pediatr Neurol 2019 Oct;99:64-68. Epub 2019 Mar 22 doi: 10.1016/j.pediatrneurol.2019.03.009. PMID: 31248672
MOG antibody-associated encephalomyelitis/encephalitis.
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome.
Wong YYM, Hacohen Y, Armangue T, Wassmer E, Verhelst H, Hemingway C, van Pelt ED, Catsman-Berrevoets CE, Hintzen RQ, Deiva K, Lim MJ, Rostásy K, Neuteboom RF
Eur J Neurol 2018 May;25(5):782-786. Epub 2018 Mar 9 doi: 10.1111/ene.13602. PMID: 29443442

Prognosis

Myelin Oligodendrocyte Glycoprotein-Associated Disorders.
Longbrake E
Continuum (Minneap Minn) 2022 Aug 1;28(4):1171-1193. doi: 10.1212/CON.0000000000001127. PMID: 35938661Free PMC Article
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Rempe T, Tarhan B, Rodriguez E, Viswanathan VT, Gyang TV, Carlson A, Tuna IS, Rees J
Mult Scler Relat Disord 2021 Feb;48:102718. Epub 2020 Dec 24 doi: 10.1016/j.msard.2020.102718. PMID: 33388560
Seropositive anti-MOG antibody-associated acute disseminated encephalomyelitis (ADEM): a sequelae of Mycoplasma pneumoniae infection.
Bonagiri P, Park D, Ingebritsen J, Christie LJ
BMJ Case Rep 2020 May 19;13(5) doi: 10.1136/bcr-2020-234565. PMID: 32434879Free PMC Article
Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with optic neuritis and seizures.
Gutman JM, Kupersmith M, Galetta S, Kister I
J Neurol Sci 2018 Apr 15;387:170-173. Epub 2018 Feb 2 doi: 10.1016/j.jns.2018.01.042. PMID: 29571858
Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.
Ramanathan S, Dale RC, Brilot F
Autoimmun Rev 2016 Apr;15(4):307-24. Epub 2015 Dec 17 doi: 10.1016/j.autrev.2015.12.004. PMID: 26708342

Clinical prediction guides

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.
Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780
Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article
Serial Anti-Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes.
Waters P, Fadda G, Woodhall M, O'Mahony J, Brown RA, Castro DA, Longoni G, Irani SR, Sun B, Yeh EA, Marrie RA, Arnold DL, Banwell B, Bar-Or A; Canadian Pediatric Demyelinating Disease Network
JAMA Neurol 2020 Jan 1;77(1):82-93. doi: 10.1001/jamaneurol.2019.2940. PMID: 31545352Free PMC Article
Anti-MOG antibodies plead against MS diagnosis in an Acquired Demyelinating Syndromes cohort.
Ketelslegers IA, Van Pelt DE, Bryde S, Neuteboom RF, Catsman-Berrevoets CE, Hamann D, Hintzen RQ
Mult Scler 2015 Oct;21(12):1513-20. Epub 2015 Feb 6 doi: 10.1177/1352458514566666. PMID: 25662345
Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis.
Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E, Derfuss T
Neurology 2011 Aug 9;77(6):580-8. Epub 2011 Jul 27 doi: 10.1212/WNL.0b013e318228c0b1. PMID: 21795651

Recent systematic reviews

Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Aug 27 doi: 10.1212/NXI.0000000000001080. PMID: 34452974Free PMC Article
Aseptic meningitis and leptomeningeal enhancement associated with anti-MOG antibodies: A review.
Gombolay GY, Gadde JA
J Neuroimmunol 2021 Sep 15;358:577653. Epub 2021 Jul 1 doi: 10.1016/j.jneuroim.2021.577653. PMID: 34229204

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