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Non-acquired pituitary hormone deficiency

MedGen UID:
1842784
•Concept ID:
C5681572
•
Disease or Syndrome
Synonym: non-acquired pituitary hormone deficiency
 
Monarch Initiative: MONDO:0019824
Orphanet: ORPHA95488

Recent clinical studies

Etiology

Clinical lessons learned in constitutional hypopituitarism from two decades of experience in a large international cohort.
Jullien N, Saveanu A, Vergier J, Marquant E, Quentien MH, Castinetti F, Galon-Faure N, Brauner R, Marrakchi Turki Z, Tauber M, El Kholy M, Linglart A, Rodien P, Fedala NS, Bergada I, Cortet-Rudelli C, Polak M, Nicolino M, Stuckens C, Barlier A, Brue T, Reynaud R; Genhypopit Network
Clin Endocrinol (Oxf) 2021 Feb;94(2):277-289. Epub 2020 Dec 21 doi: 10.1111/cen.14355. PMID: 33098107
Impact of the underlying etiology of growth hormone deficiency on serum IGF-I SDS levels during GH treatment in children.
Léger J, Mohamed D, Dos Santos S, Ben Azoun M, Zénaty D, Simon D, Paulsen A, Martinerie L, Chevenne D, Alberti C, Carel JC, Guilmin-Crepon S
Eur J Endocrinol 2017 Sep;177(3):267-276. doi: 10.1530/EJE-17-0215. PMID: 28760908
Response of Indian growth hormone deficient children to growth hormone therapy: association with pituitary size.
Khadilkar VV, Prasad HK, Ekbote VH, Rustagi VT, Singh J, Chiplonkar SA, Khadilkar AV
Indian J Pediatr 2015 May;82(5):404-9. Epub 2014 Apr 29 doi: 10.1007/s12098-014-1412-9. PMID: 24777622

Diagnosis

Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency.
Ranke MB
Front Endocrinol (Lausanne) 2021;12:720419. Epub 2021 Sep 1 doi: 10.3389/fendo.2021.720419. PMID: 34539573Free PMC Article
Clinical lessons learned in constitutional hypopituitarism from two decades of experience in a large international cohort.
Jullien N, Saveanu A, Vergier J, Marquant E, Quentien MH, Castinetti F, Galon-Faure N, Brauner R, Marrakchi Turki Z, Tauber M, El Kholy M, Linglart A, Rodien P, Fedala NS, Bergada I, Cortet-Rudelli C, Polak M, Nicolino M, Stuckens C, Barlier A, Brue T, Reynaud R; Genhypopit Network
Clin Endocrinol (Oxf) 2021 Feb;94(2):277-289. Epub 2020 Dec 21 doi: 10.1111/cen.14355. PMID: 33098107
Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non-acquired GH deficiency (naGHD): observations from a single center over a period of five decades.
Ranke MB, Schweizer R, Binder G
J Pediatr Endocrinol Metab 2018 Nov 27;31(11):1257-1266. doi: 10.1515/jpem-2018-0025. PMID: 30332395
Secondary IGF-I deficiency as a prognostic factor of growth hormone (GH) therapy effectiveness in children with isolated, non-acquired GH deficiency.
Smyczyńska J, Stawerska R, Hilczer M, Lewiński A
Exp Clin Endocrinol Diabetes 2015 Apr;123(4):209-14. Epub 2015 Jan 21 doi: 10.1055/s-0034-1395665. PMID: 25607339
Incidence and predictors of persistent growth hormone deficiency (GHD) in patients with isolated, childhood-onset GHD.
Smyczyńska J, Stawerska R, Lewiński A, Hilczer M
Endokrynol Pol 2014;65(5):334-41. doi: 10.5603/EP.2014.0046. PMID: 25301482

Therapy

Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency.
Ranke MB
Front Endocrinol (Lausanne) 2021;12:720419. Epub 2021 Sep 1 doi: 10.3389/fendo.2021.720419. PMID: 34539573Free PMC Article
Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non-acquired GH deficiency (naGHD): observations from a single center over a period of five decades.
Ranke MB, Schweizer R, Binder G
J Pediatr Endocrinol Metab 2018 Nov 27;31(11):1257-1266. doi: 10.1515/jpem-2018-0025. PMID: 30332395
Secondary IGF-I deficiency as a prognostic factor of growth hormone (GH) therapy effectiveness in children with isolated, non-acquired GH deficiency.
Smyczyńska J, Stawerska R, Hilczer M, Lewiński A
Exp Clin Endocrinol Diabetes 2015 Apr;123(4):209-14. Epub 2015 Jan 21 doi: 10.1055/s-0034-1395665. PMID: 25607339
Response of Indian growth hormone deficient children to growth hormone therapy: association with pituitary size.
Khadilkar VV, Prasad HK, Ekbote VH, Rustagi VT, Singh J, Chiplonkar SA, Khadilkar AV
Indian J Pediatr 2015 May;82(5):404-9. Epub 2014 Apr 29 doi: 10.1007/s12098-014-1412-9. PMID: 24777622
Incidence and predictors of persistent growth hormone deficiency (GHD) in patients with isolated, childhood-onset GHD.
Smyczyńska J, Stawerska R, Lewiński A, Hilczer M
Endokrynol Pol 2014;65(5):334-41. doi: 10.5603/EP.2014.0046. PMID: 25301482

Prognosis

Secondary IGF-I deficiency as a prognostic factor of growth hormone (GH) therapy effectiveness in children with isolated, non-acquired GH deficiency.
Smyczyńska J, Stawerska R, Hilczer M, Lewiński A
Exp Clin Endocrinol Diabetes 2015 Apr;123(4):209-14. Epub 2015 Jan 21 doi: 10.1055/s-0034-1395665. PMID: 25607339
Response of Indian growth hormone deficient children to growth hormone therapy: association with pituitary size.
Khadilkar VV, Prasad HK, Ekbote VH, Rustagi VT, Singh J, Chiplonkar SA, Khadilkar AV
Indian J Pediatr 2015 May;82(5):404-9. Epub 2014 Apr 29 doi: 10.1007/s12098-014-1412-9. PMID: 24777622
Incidence and predictors of persistent growth hormone deficiency (GHD) in patients with isolated, childhood-onset GHD.
Smyczyńska J, Stawerska R, Lewiński A, Hilczer M
Endokrynol Pol 2014;65(5):334-41. doi: 10.5603/EP.2014.0046. PMID: 25301482

Clinical prediction guides

Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non-acquired GH deficiency (naGHD): observations from a single center over a period of five decades.
Ranke MB, Schweizer R, Binder G
J Pediatr Endocrinol Metab 2018 Nov 27;31(11):1257-1266. doi: 10.1515/jpem-2018-0025. PMID: 30332395
Impact of the underlying etiology of growth hormone deficiency on serum IGF-I SDS levels during GH treatment in children.
Léger J, Mohamed D, Dos Santos S, Ben Azoun M, Zénaty D, Simon D, Paulsen A, Martinerie L, Chevenne D, Alberti C, Carel JC, Guilmin-Crepon S
Eur J Endocrinol 2017 Sep;177(3):267-276. doi: 10.1530/EJE-17-0215. PMID: 28760908
Secondary IGF-I deficiency as a prognostic factor of growth hormone (GH) therapy effectiveness in children with isolated, non-acquired GH deficiency.
Smyczyńska J, Stawerska R, Hilczer M, Lewiński A
Exp Clin Endocrinol Diabetes 2015 Apr;123(4):209-14. Epub 2015 Jan 21 doi: 10.1055/s-0034-1395665. PMID: 25607339
Response of Indian growth hormone deficient children to growth hormone therapy: association with pituitary size.
Khadilkar VV, Prasad HK, Ekbote VH, Rustagi VT, Singh J, Chiplonkar SA, Khadilkar AV
Indian J Pediatr 2015 May;82(5):404-9. Epub 2014 Apr 29 doi: 10.1007/s12098-014-1412-9. PMID: 24777622
Incidence and predictors of persistent growth hormone deficiency (GHD) in patients with isolated, childhood-onset GHD.
Smyczyńska J, Stawerska R, Lewiński A, Hilczer M
Endokrynol Pol 2014;65(5):334-41. doi: 10.5603/EP.2014.0046. PMID: 25301482

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