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Juvenile myasthenia gravis

MedGen UID:
1842990
Concept ID:
C5680023
Disease or Syndrome
Synonyms: childhood myasthenia gravis; Childhood myasthenia gravis; Juvenile acquired myasthenia; juvenile acquired myasthenia; Juvenile autoimmune myasthenia gravis; juvenile autoimmune myasthenia gravis; juvenile myasthenia gravis; myasthenia gravis of childhood; paediatric myasthenia gravis; pediatric myasthenia gravis
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018325
Orphanet: ORPHA391497

Definition

Juvenile myasthenia gravis (MG; see this term) is a rare form of MG, an autoimmune disorder of the neuromuscular junction resulting in ocular manifestations or generalized weakness, with onset before 18 years of age. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile myasthenia gravis

Professional guidelines

PubMed

Özsoy Ö, Cinleti T, Günay Ç, Sarıkaya Uzan G, Giray Bozkaya Ö, Çağlayan AO, Hız Kurul S, Yiş U
Acta Neurol Belg 2023 Dec;123(6):2325-2335. Epub 2023 Sep 1 doi: 10.1007/s13760-023-02370-3. PMID: 37656362
Della Marina A, Trippe H, Lutz S, Schara U
Neuropediatrics 2014 Apr;45(2):75-83. Epub 2014 Jan 27 doi: 10.1055/s-0033-1364181. PMID: 24470240
Ionita CM, Acsadi G
Pediatr Neurol 2013 Feb;48(2):95-104. doi: 10.1016/j.pediatrneurol.2012.07.008. PMID: 23337001

Recent clinical studies

Etiology

Ramdas S, Della Marina A, Ryan MM, McWilliam K, Klein A, Jacquier D, Alabaf S, Childs AM, Parasuraman D, Beeson D, Palace J, Jungbluth H
Eur J Paediatr Neurol 2022 Sep;40:5-10. Epub 2022 Jun 25 doi: 10.1016/j.ejpn.2022.06.009. PMID: 35835035
Ng WC, Hartley L
Neuromuscul Disord 2021 Nov;31(11):1113-1123. Epub 2021 Oct 8 doi: 10.1016/j.nmd.2021.09.013. PMID: 34756789
Kim AG, Upah SA, Brandsema JF, Yum SW, Blinman TA
Pediatr Surg Int 2019 May;35(5):603-610. Epub 2019 Feb 7 doi: 10.1007/s00383-019-04441-0. PMID: 30729982Free PMC Article
Della Marina A, Trippe H, Lutz S, Schara U
Neuropediatrics 2014 Apr;45(2):75-83. Epub 2014 Jan 27 doi: 10.1055/s-0033-1364181. PMID: 24470240
Chiang LM, Darras BT, Kang PB
Muscle Nerve 2009 Apr;39(4):423-31. doi: 10.1002/mus.21195. PMID: 19229875

Diagnosis

Rathore G, Kang PB
Pediatr Neurol 2023 Dec;149:1-14. Epub 2023 Aug 29 doi: 10.1016/j.pediatrneurol.2023.08.034. PMID: 37757659
Peragallo JH
Semin Pediatr Neurol 2017 May;24(2):116-121. Epub 2017 Apr 7 doi: 10.1016/j.spen.2017.04.003. PMID: 28941526
Della Marina A, Trippe H, Lutz S, Schara U
Neuropediatrics 2014 Apr;45(2):75-83. Epub 2014 Jan 27 doi: 10.1055/s-0033-1364181. PMID: 24470240
Liew WK, Kang PB
Curr Opin Pediatr 2013 Dec;25(6):694-700. doi: 10.1097/MOP.0b013e328365ad16. PMID: 24141560
Chiang LM, Darras BT, Kang PB
Muscle Nerve 2009 Apr;39(4):423-31. doi: 10.1002/mus.21195. PMID: 19229875

Therapy

Ramdas S, Della Marina A, Ryan MM, McWilliam K, Klein A, Jacquier D, Alabaf S, Childs AM, Parasuraman D, Beeson D, Palace J, Jungbluth H
Eur J Paediatr Neurol 2022 Sep;40:5-10. Epub 2022 Jun 25 doi: 10.1016/j.ejpn.2022.06.009. PMID: 35835035
Kim AG, Upah SA, Brandsema JF, Yum SW, Blinman TA
Pediatr Surg Int 2019 May;35(5):603-610. Epub 2019 Feb 7 doi: 10.1007/s00383-019-04441-0. PMID: 30729982Free PMC Article
Liew WK, Kang PB
Curr Opin Pediatr 2013 Dec;25(6):694-700. doi: 10.1097/MOP.0b013e328365ad16. PMID: 24141560
Ionita CM, Acsadi G
Pediatr Neurol 2013 Feb;48(2):95-104. doi: 10.1016/j.pediatrneurol.2012.07.008. PMID: 23337001
Chiang LM, Darras BT, Kang PB
Muscle Nerve 2009 Apr;39(4):423-31. doi: 10.1002/mus.21195. PMID: 19229875

Prognosis

Arroyo HA, Torres AR
Neuromuscul Disord 2022 Mar;32(3):213-219. Epub 2022 Jan 12 doi: 10.1016/j.nmd.2021.11.014. PMID: 35094888
Kim AG, Upah SA, Brandsema JF, Yum SW, Blinman TA
Pediatr Surg Int 2019 May;35(5):603-610. Epub 2019 Feb 7 doi: 10.1007/s00383-019-04441-0. PMID: 30729982Free PMC Article
Lee HN, Kang HC, Lee JS, Kim HD, Shin HY, Kim SM, Sunwoo IN, Lee YM
J Child Neurol 2016 Dec;31(14):1561-1568. Epub 2016 Aug 31 doi: 10.1177/0883073816666206. PMID: 27581849
Della Marina A, Trippe H, Lutz S, Schara U
Neuropediatrics 2014 Apr;45(2):75-83. Epub 2014 Jan 27 doi: 10.1055/s-0033-1364181. PMID: 24470240
Afifi AK, Bell WE
J Child Neurol 1993 Oct;8(4):403-11. doi: 10.1177/088307389300800422. PMID: 8228040

Clinical prediction guides

Özsoy Ö, Cinleti T, Günay Ç, Sarıkaya Uzan G, Giray Bozkaya Ö, Çağlayan AO, Hız Kurul S, Yiş U
Acta Neurol Belg 2023 Dec;123(6):2325-2335. Epub 2023 Sep 1 doi: 10.1007/s13760-023-02370-3. PMID: 37656362
Molimard A, Gitiaux C, Barnerias C, Audic F, Isapof A, Walther-Louvier U, Cances C, Espil-Taris C, Davion JB, Quijano-Roy S, Grisel C, Chabrol B, Desguerre I
Neurology 2022 Jun 7;98(23):e2368-e2376. Epub 2022 Mar 21 doi: 10.1212/WNL.0000000000200288. PMID: 35314497
Li Z, Li F, Zhang H, Swierzy M, Ismail M, Meisel A, Rueckert JC
Ann Thorac Surg 2022 Jan;113(1):295-301. Epub 2021 Jan 19 doi: 10.1016/j.athoracsur.2020.12.045. PMID: 33482164
Bhatia S, Quinlan H, McCracken C, Price EW, Guglani L, Verma S
Muscle Nerve 2018 Nov;58(5):729-732. Epub 2018 Oct 2 doi: 10.1002/mus.26319. PMID: 30106469
Afifi AK, Bell WE
J Child Neurol 1993 Oct;8(4):403-11. doi: 10.1177/088307389300800422. PMID: 8228040

Recent systematic reviews

Madenci AL, Li GZ, Weil BR, Zurakowski D, Kang PB, Weldon CB
Pediatr Surg Int 2017 Jun;33(6):683-694. Epub 2017 Apr 11 doi: 10.1007/s00383-017-4086-3. PMID: 28401300

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