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Postgastrectomy syndrome

MedGen UID:
18588
•Concept ID:
C0032763
•
Disease or Syndrome
Synonyms: Postgastrectomy Syndrome; Postgastrectomy Syndromes; Syndrome, Postgastrectomy; Syndromes, Postgastrectomy
SNOMED CT: Postgastric surgery syndrome (80193009); Jejunal syndrome (80193009); Postgastrectomy syndrome (80193009); Post-cibal syndrome (80193009)
 
Monarch Initiative: MONDO:0004566

Definition

Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (dumping syndrome and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostgastrectomy syndrome

Professional guidelines

PubMed

Alkaline reflux gastritis. Late results on a controlled trial of diagnosis and treatment.
Ritchie WP Jr
Ann Surg 1986 May;203(5):537-44. doi: 10.1097/00000658-198605000-00014. PMID: 3707233Free PMC Article
Alkaline reflux gastritis. An objective assessment of its diagnosis and treatment.
Ritchie WP Jr
Ann Surg 1980 Sep;192(3):288-98. doi: 10.1097/00000658-198009000-00003. PMID: 7416826Free PMC Article

Recent clinical studies

Etiology

Clinical Relevance of Proximal Gastrectomy With Double-flap Esophagogastrostomy Reconstruction With Glycemic Profile and Postgastrectomy Syndromes.
Shibamoto J, Kubota T, Nishibeppu K, Ohashi T, Konishi H, Shiozaki A, Fujiwara H, Otsuji E
Anticancer Res 2023 Feb;43(2):857-864. doi: 10.21873/anticanres.16228. PMID: 36697086
A comparative study of laparoscopic near-total and total gastrectomy for patient nutritional status and quality of life using a propensity score matching analysis.
Ko CS, Gong CS, Kim BS, Kim SO, Kim HS
Surg Endosc 2022 Aug;36(8):5610-5617. Epub 2022 May 25 doi: 10.1007/s00464-021-08959-0. PMID: 35612639
Optimal Procedures for Double Tract Reconstruction After Proximal Gastrectomy Assessed by Postgastrectomy Syndrome Assessment Scale-45.
Kamiya S, Namikawa T, Takahashi M, Hasegawa Y, Ikeda M, Kinami S, Isozaki H, Takeuchi H, Oshio A, Nakada K
J Gastrointest Surg 2022 Sep;26(9):1817-1829. Epub 2022 May 6 doi: 10.1007/s11605-022-05328-7. PMID: 35524078
Roux-en-Y versus Billroth-I reconstruction after distal gastrectomy for gastric cancer.
Nishizaki D, Ganeko R, Hoshino N, Hida K, Obama K, Furukawa TA, Sakai Y, Watanabe N
Cochrane Database Syst Rev 2021 Sep 15;9(9):CD012998. doi: 10.1002/14651858.CD012998.pub2. PMID: 34523717Free PMC Article
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study.
Fujita J, Takahashi M, Urushihara T, Tanabe K, Kodera Y, Yumiba T, Matsumoto H, Takagane A, Kunisaki C, Nakada K
Gastric Cancer 2016 Jan;19(1):302-11. Epub 2015 Jan 31 doi: 10.1007/s10120-015-0460-9. PMID: 25637175

Diagnosis

Optimal Procedures for Double Tract Reconstruction After Proximal Gastrectomy Assessed by Postgastrectomy Syndrome Assessment Scale-45.
Kamiya S, Namikawa T, Takahashi M, Hasegawa Y, Ikeda M, Kinami S, Isozaki H, Takeuchi H, Oshio A, Nakada K
J Gastrointest Surg 2022 Sep;26(9):1817-1829. Epub 2022 May 6 doi: 10.1007/s11605-022-05328-7. PMID: 35524078
Roux-en-Y versus Billroth-I reconstruction after distal gastrectomy for gastric cancer.
Nishizaki D, Ganeko R, Hoshino N, Hida K, Obama K, Furukawa TA, Sakai Y, Watanabe N
Cochrane Database Syst Rev 2021 Sep 15;9(9):CD012998. doi: 10.1002/14651858.CD012998.pub2. PMID: 34523717Free PMC Article
Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45.
Tanizawa Y, Tanabe K, Kawahira H, Fujita J, Takiguchi N, Takahashi M, Ito Y, Mitsumori N, Namikawa T, Oshio A, Nakada K; Japan Postgastrectomy Syndrome Working Party
Dig Surg 2016;33(2):94-103. Epub 2015 Dec 18 doi: 10.1159/000442217. PMID: 26682541
Postgastrectomy syndromes.
Bolton JS, Conway WC 2nd
Surg Clin North Am 2011 Oct;91(5):1105-22. doi: 10.1016/j.suc.2011.07.001. PMID: 21889032
Alkaline reflux gastritis.
Ritchie WP Jr
Gastroenterol Clin North Am 1994 Jun;23(2):281-94. PMID: 8070913

Therapy

Clinical Relevance of Proximal Gastrectomy With Double-flap Esophagogastrostomy Reconstruction With Glycemic Profile and Postgastrectomy Syndromes.
Shibamoto J, Kubota T, Nishibeppu K, Ohashi T, Konishi H, Shiozaki A, Fujiwara H, Otsuji E
Anticancer Res 2023 Feb;43(2):857-864. doi: 10.21873/anticanres.16228. PMID: 36697086
Roux-en-Y versus Billroth-I reconstruction after distal gastrectomy for gastric cancer.
Nishizaki D, Ganeko R, Hoshino N, Hida K, Obama K, Furukawa TA, Sakai Y, Watanabe N
Cochrane Database Syst Rev 2021 Sep 15;9(9):CD012998. doi: 10.1002/14651858.CD012998.pub2. PMID: 34523717Free PMC Article
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study.
Fujita J, Takahashi M, Urushihara T, Tanabe K, Kodera Y, Yumiba T, Matsumoto H, Takagane A, Kunisaki C, Nakada K
Gastric Cancer 2016 Jan;19(1):302-11. Epub 2015 Jan 31 doi: 10.1007/s10120-015-0460-9. PMID: 25637175
Characteristics and clinical relevance of postgastrectomy syndrome assessment scale (PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life in postgastrectomy patients.
Nakada K, Ikeda M, Takahashi M, Kinami S, Yoshida M, Uenosono Y, Kawashima Y, Oshio A, Suzukamo Y, Terashima M, Kodera Y
Gastric Cancer 2015 Jan;18(1):147-58. Epub 2014 Feb 11 doi: 10.1007/s10120-014-0344-4. PMID: 24515247
Postgastrectomy syndromes.
Bolton JS, Conway WC 2nd
Surg Clin North Am 2011 Oct;91(5):1105-22. doi: 10.1016/j.suc.2011.07.001. PMID: 21889032

Prognosis

Evaluation of Quality of Life and Prognosis of Gastric Cancer Patients After Laparoscopic Subtotal Gastrectomy.
Shimonosono M, Arigami T, Matsushita D, Tsuruda Y, Sasaki K, Baba K, Uchikado Y, Kurahara H, Ohtsuka T
Anticancer Res 2024 Jan;44(1):387-396. doi: 10.21873/anticanres.16823. PMID: 38159990
Postoperative quality of life after laparoscopy-assisted pylorus-preserving gastrectomy compared With laparoscopy-assisted distal gastrectomy: A cross-sectional postal questionnaire survey.
Hosoda K, Yamashita K, Sakuramoto S, Katada N, Moriya H, Mieno H, Watanabe M
Am J Surg 2017 Apr;213(4):763-770. Epub 2016 Oct 8 doi: 10.1016/j.amjsurg.2016.09.041. PMID: 27751530
Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study.
Fujita J, Takahashi M, Urushihara T, Tanabe K, Kodera Y, Yumiba T, Matsumoto H, Takagane A, Kunisaki C, Nakada K
Gastric Cancer 2016 Jan;19(1):302-11. Epub 2015 Jan 31 doi: 10.1007/s10120-015-0460-9. PMID: 25637175
Roux-en-Y limb motility after total gastrectomy.
Herbella FA, Silva LC, Vicentine FP, Patti MG
J Gastrointest Surg 2014 May;18(5):906-10. Epub 2014 Feb 5 doi: 10.1007/s11605-014-2473-9. PMID: 24496746
Postgastrectomy syndromes.
Bolton JS, Conway WC 2nd
Surg Clin North Am 2011 Oct;91(5):1105-22. doi: 10.1016/j.suc.2011.07.001. PMID: 21889032

Clinical prediction guides

Clinical Relevance of Proximal Gastrectomy With Double-flap Esophagogastrostomy Reconstruction With Glycemic Profile and Postgastrectomy Syndromes.
Shibamoto J, Kubota T, Nishibeppu K, Ohashi T, Konishi H, Shiozaki A, Fujiwara H, Otsuji E
Anticancer Res 2023 Feb;43(2):857-864. doi: 10.21873/anticanres.16228. PMID: 36697086
An early interactive human coaching via a mobile application to improve quality of life in patients who underwent gastrectomy for gastric cancer: Design and protocol of a randomized controlled trial.
Kim HJ, Yoon HM, Ryu KW, Kim YW, Kim SY, Oh JM, Wie GA, Ko H, Lee J, Kim Y, Cho H, Eom BW
PLoS One 2022;17(12):e0278370. Epub 2022 Dec 9 doi: 10.1371/journal.pone.0278370. PMID: 36490244Free PMC Article
A comparative study of laparoscopic near-total and total gastrectomy for patient nutritional status and quality of life using a propensity score matching analysis.
Ko CS, Gong CS, Kim BS, Kim SO, Kim HS
Surg Endosc 2022 Aug;36(8):5610-5617. Epub 2022 May 25 doi: 10.1007/s00464-021-08959-0. PMID: 35612639
Optimal Procedures for Double Tract Reconstruction After Proximal Gastrectomy Assessed by Postgastrectomy Syndrome Assessment Scale-45.
Kamiya S, Namikawa T, Takahashi M, Hasegawa Y, Ikeda M, Kinami S, Isozaki H, Takeuchi H, Oshio A, Nakada K
J Gastrointest Surg 2022 Sep;26(9):1817-1829. Epub 2022 May 6 doi: 10.1007/s11605-022-05328-7. PMID: 35524078
Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45.
Tanizawa Y, Tanabe K, Kawahira H, Fujita J, Takiguchi N, Takahashi M, Ito Y, Mitsumori N, Namikawa T, Oshio A, Nakada K; Japan Postgastrectomy Syndrome Working Party
Dig Surg 2016;33(2):94-103. Epub 2015 Dec 18 doi: 10.1159/000442217. PMID: 26682541

Recent systematic reviews

Roux-en-Y with or without jejunal J-pouch reconstruction after total gastrectomy for gastric cancer: systematic review and meta-analysis of long-term functional outcomes.
Realis Luc M, Bonomi AM, Carbone F, Ascari F, de Pascale S, Fumagalli Romario U
J Gastrointest Surg 2024 Mar;28(3):291-300. Epub 2024 Jan 19 doi: 10.1016/j.gassur.2023.12.015. PMID: 38445924
Uncut Roux-en-Y reconstruction after distal gastrectomy for gastric cancer.
Cai Z, Mu M, Ma Q, Liu C, Jiang Z, Liu B, Ji G, Zhang B
Cochrane Database Syst Rev 2024 Feb 29;2(2):CD015014. doi: 10.1002/14651858.CD015014.pub2. PMID: 38421211Free PMC Article
Roux-en-Y versus Billroth-I reconstruction after distal gastrectomy for gastric cancer.
Nishizaki D, Ganeko R, Hoshino N, Hida K, Obama K, Furukawa TA, Sakai Y, Watanabe N
Cochrane Database Syst Rev 2021 Sep 15;9(9):CD012998. doi: 10.1002/14651858.CD012998.pub2. PMID: 34523717Free PMC Article
Rikkunshito for upper gastrointestinal symptoms: A systematic review and meta-analysis.
Hoshino N, Nishizaki D, Hida K, Obama K, Sakai Y
Complement Ther Med 2019 Feb;42:255-263. Epub 2018 Nov 30 doi: 10.1016/j.ctim.2018.11.025. PMID: 30670250

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