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Ectopic pregnancy

MedGen UID:
18618
Concept ID:
C0032987
Pathologic Function
Synonyms: Ectopic Pregnancies; Ectopic Pregnancy; Extrauterine Pregnancies; Extrauterine Pregnancy; Pregnancies, Ectopic; Pregnancies, Extrauterine; Pregnancy, Ectopic; Pregnancy, Extrauterine
SNOMED CT: EP - Ectopic pregnancy (34801009); Ectopic pregnancy (34801009)
 
HPO: HP:0031456
Monarch Initiative: MONDO:0000755

Definition

A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube). [from HPO]

Professional guidelines

PubMed

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
Curry A, Williams T, Penny ML
Am Fam Physician 2019 Sep 15;100(6):357-364. PMID: 31524362

Curated

UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

Recent clinical studies

Etiology

Ban Y, Shen J, Wang X, Zhang T, Lu X, Qu W, Hao Y, Mao Z, Li S, Tao G, Wang F, Zhao Y, Zhang X, Zhang Y, Zhang G, Cui B
Obstet Gynecol 2023 May 1;141(5):927-936. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005113. PMID: 37023450Free PMC Article
Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Farquhar CM
Lancet 2005 Aug 13-19;366(9485):583-91. doi: 10.1016/S0140-6736(05)67103-6. PMID: 16099295

Diagnosis

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Houser M, Kandalaft N, Khati NJ
Emerg Radiol 2022 Feb;29(1):161-172. Epub 2021 Oct 7 doi: 10.1007/s10140-021-01974-7. PMID: 34618256
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Farquhar CM
Lancet 2005 Aug 13-19;366(9485):583-91. doi: 10.1016/S0140-6736(05)67103-6. PMID: 16099295

Therapy

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Tonick S, Conageski C
Obstet Gynecol Clin North Am 2022 Sep;49(3):537-549. doi: 10.1016/j.ogc.2022.02.018. PMID: 36122984
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Gonzalez N, Tulandi T
J Minim Invasive Gynecol 2017 Jul-Aug;24(5):731-738. Epub 2017 Mar 6 doi: 10.1016/j.jmig.2017.02.020. PMID: 28268103
Taran FA, Kagan KO, Hübner M, Hoopmann M, Wallwiener D, Brucker S
Dtsch Arztebl Int 2015 Oct 9;112(41):693-703; quiz 704-5. doi: 10.3238/arztebl.2015.0693. PMID: 26554319Free PMC Article

Prognosis

Farren J, Jalmbrant M, Falconieri N, Mitchell-Jones N, Bobdiwala S, Al-Memar M, Tapp S, Van Calster B, Wynants L, Timmerman D, Bourne T
Am J Obstet Gynecol 2020 Apr;222(4):367.e1-367.e22. Epub 2019 Dec 13 doi: 10.1016/j.ajog.2019.10.102. PMID: 31953115
Skerlev M, Čulav-Košćak I
Clin Dermatol 2014 Mar-Apr;32(2):275-81. doi: 10.1016/j.clindermatol.2013.08.010. PMID: 24559563
Marion LL, Meeks GR
Clin Obstet Gynecol 2012 Jun;55(2):376-86. doi: 10.1097/GRF.0b013e3182516d7b. PMID: 22510618
Varma R, Gupta J
BMJ Clin Evid 2012 Feb 10;2012 PMID: 22321966Free PMC Article
Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF
Lancet 2006 Apr 1;367(9516):1066-1074. doi: 10.1016/S0140-6736(06)68397-9. PMID: 16581405

Clinical prediction guides

Nijjar S, Jauniaux E, Jurkovic D
Best Pract Res Clin Obstet Gynaecol 2023 Jul;89:102360. Epub 2023 May 31 doi: 10.1016/j.bpobgyn.2023.102360. PMID: 37356119
Ban Y, Shen J, Wang X, Zhang T, Lu X, Qu W, Hao Y, Mao Z, Li S, Tao G, Wang F, Zhao Y, Zhang X, Zhang Y, Zhang G, Cui B
Obstet Gynecol 2023 May 1;141(5):927-936. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005113. PMID: 37023450Free PMC Article
Yong PJ, Matwani S, Brace C, Quaiattini A, Bedaiwy MA, Albert A, Allaire C
J Minim Invasive Gynecol 2020 Feb;27(2):352-361.e2. Epub 2019 Sep 20 doi: 10.1016/j.jmig.2019.09.778. PMID: 31546066
Bobdiwala S, Al-Memar M, Farren J, Bourne T
Womens Health (Lond) 2017 Aug;13(2):27-33. Epub 2017 Jun 29 doi: 10.1177/1745505717709677. PMID: 28660799Free PMC Article
Bottomley C, Bourne T
Best Pract Res Clin Obstet Gynaecol 2009 Aug;23(4):463-77. Epub 2009 Jun 6 doi: 10.1016/j.bpobgyn.2009.02.004. PMID: 19502113

Recent systematic reviews

Xiao C, Shi Q, Cheng Q, Xu J
Medicine (Baltimore) 2021 Dec 17;100(50):e27851. doi: 10.1097/MD.0000000000027851. PMID: 34918633Free PMC Article
Ozcan MCH, Wilson JR, Frishman GN
J Minim Invasive Gynecol 2021 Mar;28(3):656-667. Epub 2020 Oct 24 doi: 10.1016/j.jmig.2020.10.014. PMID: 33198948
Calì G, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteaugudo A, Buca D, Forlani F, Familiari A, Scambia G, Acharya G, D'Antonio F
Ultrasound Obstet Gynecol 2018 Feb;51(2):169-175. doi: 10.1002/uog.17568. PMID: 28661021
Gonzalez N, Tulandi T
J Minim Invasive Gynecol 2017 Jul-Aug;24(5):731-738. Epub 2017 Mar 6 doi: 10.1016/j.jmig.2017.02.020. PMID: 28268103
Birch Petersen K, Hoffmann E, Rifbjerg Larsen C, Svarre Nielsen H
Fertil Steril 2016 Apr;105(4):958-67. Epub 2016 Jan 18 doi: 10.1016/j.fertnstert.2015.12.130. PMID: 26794422

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

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