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Mycoplasma pneumoniae pneumonia

MedGen UID:
19363
•Concept ID:
C0032302
•
Disease or Syndrome
Synonym: Mycoplasmal pneumonia
SNOMED CT: Pneumonia due to Mycoplasma pneumoniae (46970008); Eaton's agent pneumonia (46970008); Pneumonia caused by Mycoplasma pneumoniae (46970008); Primary atypical pneumonia caused by Mycoplasma pneumoniae (46970008); Mycoplasma pneumoniae pneumonia (46970008); Mycoplasmal pneumonia (46970008); Mycoplasma pneumonia (46970008); Primary atypical pneumonia due to Mycoplasma pneumoniae (46970008); Endemic pneumonia (46970008)
 
Monarch Initiative: MONDO:0005867

Definition

Pneumonia caused by Mycoplasma pneumoniae. Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMycoplasma pneumoniae pneumonia

Professional guidelines

PubMed

Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article
The treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Dai FF, Liu FQ, Chen X, Yang J, Wang K, Guo CY
J Clin Pharm Ther 2021 Jun;46(3):705-710. Epub 2021 Jan 6 doi: 10.1111/jcpt.13331. PMID: 33403672

Recent clinical studies

Etiology

Immune response plays a role in Mycoplasma pneumoniae pneumonia.
Zhu Y, Luo Y, Li L, Jiang X, Du Y, Wang J, Li H, Gu H, Li D, Tang H, Qin H, Xu C, Liu Y, Zhao D, Guo Y, Liu F
Front Immunol 2023;14:1189647. Epub 2023 May 26 doi: 10.3389/fimmu.2023.1189647. PMID: 37304280Free PMC Article
Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.
Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A
Emerg Microbes Infect 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272. PMID: 37132354Free PMC Article
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Lee H, Yun KW, Lee HJ, Choi EH
Expert Rev Anti Infect Ther 2018 Jan;16(1):23-34. Epub 2017 Dec 11 doi: 10.1080/14787210.2018.1414599. PMID: 29212389

Diagnosis

Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children.
Fan F, Lv J, Yang Q, Jiang F
Clin Respir J 2023 Jul;17(7):607-617. Epub 2023 May 4 doi: 10.1111/crj.13620. PMID: 37142438Free PMC Article
Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.
Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A
Emerg Microbes Infect 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272. PMID: 37132354Free PMC Article
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children.
Tsai TA, Tsai CK, Kuo KC, Yu HR
J Microbiol Immunol Infect 2021 Aug;54(4):557-565. Epub 2020 Oct 17 doi: 10.1016/j.jmii.2020.10.002. PMID: 33268306

Therapy

Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Mycoplasma pneumoniae triggers pneumonia epidemic in autumn and winter in Beijing: a multicentre, population-based epidemiological study between 2015 and 2020.
Wang X, Li M, Luo M, Luo Q, Kang L, Xie H, Wang Y, Yu X, Li A, Dong M, Huang F, Gong C
Emerg Microbes Infect 2022 Dec;11(1):1508-1517. doi: 10.1080/22221751.2022.2078228. PMID: 35582916Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children.
Tsai TA, Tsai CK, Kuo KC, Yu HR
J Microbiol Immunol Infect 2021 Aug;54(4):557-565. Epub 2020 Oct 17 doi: 10.1016/j.jmii.2020.10.002. PMID: 33268306
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Lee H, Yun KW, Lee HJ, Choi EH
Expert Rev Anti Infect Ther 2018 Jan;16(1):23-34. Epub 2017 Dec 11 doi: 10.1080/14787210.2018.1414599. PMID: 29212389

Prognosis

Molecular epidemiology of Mycoplasma pneumoniae pneumonia in children, Wuhan, 2020-2022.
Xu M, Li Y, Shi Y, Liu H, Tong X, Ma L, Gao J, Du Q, Du H, Liu D, Lu X, Yan Y
BMC Microbiol 2024 Jan 17;24(1):23. doi: 10.1186/s12866-024-03180-0. PMID: 38229068Free PMC Article
Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children.
Fan F, Lv J, Yang Q, Jiang F
Clin Respir J 2023 Jul;17(7):607-617. Epub 2023 May 4 doi: 10.1111/crj.13620. PMID: 37142438Free PMC Article
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Thromboembolic complications of Mycoplasma pneumoniae pneumonia in children.
Chen L, Yin J, Liu X, Liu J, Xu B, Shen K
Clin Respir J 2023 Mar;17(3):187-196. Epub 2023 Jan 19 doi: 10.1111/crj.13584. PMID: 36658687Free PMC Article
Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article

Clinical prediction guides

Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children.
Fan F, Lv J, Yang Q, Jiang F
Clin Respir J 2023 Jul;17(7):607-617. Epub 2023 May 4 doi: 10.1111/crj.13620. PMID: 37142438Free PMC Article
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article
Clinical features of Mycoplasma pneumoniae pneumonia with adenovirus infection in children.
Peng L, Zhong LL, Huang Z, Li Y, Zhang B
Zhongguo Dang Dai Er Ke Za Zhi 2021 Oct 15;23(10):1033-1037. doi: 10.7499/j.issn.1008-8830.2107080. PMID: 34719419Free PMC Article
Clinical significance of D-dimer levels in refractory Mycoplasma pneumoniae pneumonia.
Huang X, Li D, Liu F, Zhao D, Zhu Y, Tang H
BMC Infect Dis 2021 Jan 6;21(1):14. doi: 10.1186/s12879-020-05700-5. PMID: 33407216Free PMC Article

Recent systematic reviews

Cytokines and refractory mycoplasma pneumoniae pneumonia in children: a systematic review.
Yu M, Zhang Q, Yan H
Minerva Pediatr (Torino) 2024 Apr;76(2):259-267. Epub 2023 May 8 doi: 10.23736/S2724-5276.23.07158-6. PMID: 37155205
Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article
Combined therapy of Xiaoer Feire Kechuan oral liquid and azithromycin for mycoplasma Pneumoniae pneumonia in children: A systematic review & meta-analysis.
Peng Y, Chen Z, Li Y, Lu Q, Li H, Han Y, Sun D, Li X
Phytomedicine 2022 Feb;96:153899. Epub 2021 Dec 30 doi: 10.1016/j.phymed.2021.153899. PMID: 35026500
Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article
Shuanghuanglian oral preparations combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: A systematic review and meta-analysis of randomized controlled trials.
Peng Y, Chen Z, Li Y, Lu Q, Li H, Han Y, Sun D, Li X
PLoS One 2021;16(7):e0254405. Epub 2021 Jul 13 doi: 10.1371/journal.pone.0254405. PMID: 34255785Free PMC Article

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