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Brainstem glioma

MedGen UID:
195650
•Concept ID:
C0677865
•
Neoplastic Process
Synonyms: Brain Stem Glioma; brain stem glioma; Brain Stem Neuroglial Neoplasm; brain stem neuroglial neoplasm; Brain Stem Neuroglial Tumor; brain stem neuroglial tumor; brain stem neuroglial tumour; Brainstem Glioma; brainstem glioma; brainstem malignant glioma; Brainstem Neuroglial Neoplasm; brainstem neuroglial neoplasm; Brainstem Neuroglial Tumor; brainstem neuroglial tumor; brainstem neuroglial tumour; diffuse brainstem glioma; Glioma of Brain Stem; glioma of brain stem; Glioma of brainstem; Glioma of Brainstem; glioma of brainstem; Glioma of the Brain Stem; glioma of the brain stem; Glioma of the Brainstem; glioma of the brainstem; malignant glioma of brainstem
SNOMED CT: Glioma of brainstem (444545003)
 
HPO: HP:0010796
Monarch Initiative: MONDO:0002911

Definition

A glioma affecting the brainstem. [from HPO]

Professional guidelines

PubMed

Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Adult brainstem glioma differential diagnoses: an MRI-based approach in a series of 68 patients.
Duran-Peña A, Ducray F, Ramirez C, Bauchet L, Constans JM, Grand S, Guillamo JS, Larrieu-Ciron D, Frappaz D, Pyatigorskaya N, Savatovsky J, Loiseau H, Duverneuil NM, Laigle-Donadey F
J Neurol 2022 Aug;269(8):4349-4362. Epub 2022 Apr 20 doi: 10.1007/s00415-022-11070-6. PMID: 35441889

Curated

UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

Recent clinical studies

Etiology

Experimental murine models of brainstem gliomas.
Ni S, Chen R, Hu K
Drug Discov Today 2022 May;27(5):1218-1235. Epub 2021 Dec 23 doi: 10.1016/j.drudis.2021.12.016. PMID: 34954326
The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors.
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C
World Neurosurg 2021 Feb;146:e639-e650. Epub 2020 Nov 2 doi: 10.1016/j.wneu.2020.10.147. PMID: 33152495
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Improving outcomes for neurofibromatosis 1-associated brain tumors.
Brossier NM, Gutmann DH
Expert Rev Anticancer Ther 2015 Apr;15(4):415-23. Epub 2015 Feb 5 doi: 10.1586/14737140.2015.1009043. PMID: 25652347
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Diagnosis

Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature.
Leibetseder A, Leitner J, Mair MJ, Meckel S, Hainfellner JA, Aichholzer M, Widhalm G, Dieckmann K, Weis S, Furtner J, von Oertzen T, Preusser M, Pichler J, Berghoff AS
J Neurol 2022 Mar;269(3):1574-1590. Epub 2021 Aug 3 doi: 10.1007/s00415-021-10725-0. PMID: 34342680Free PMC Article
Posterior Fossa Tumors.
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Therapy

Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG).
Gwak HS, Park HJ
Crit Rev Oncol Hematol 2017 Dec;120:111-119. Epub 2017 Oct 31 doi: 10.1016/j.critrevonc.2017.10.013. PMID: 29198324
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Improving outcomes for neurofibromatosis 1-associated brain tumors.
Brossier NM, Gutmann DH
Expert Rev Anticancer Ther 2015 Apr;15(4):415-23. Epub 2015 Feb 5 doi: 10.1586/14737140.2015.1009043. PMID: 25652347
Diffuse intrinsic pontine gliomas: treatments and controversies.
Bredlau AL, Korones DN
Adv Cancer Res 2014;121:235-259. doi: 10.1016/B978-0-12-800249-0.00006-8. PMID: 24889533

Prognosis

Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors.
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C
World Neurosurg 2021 Feb;146:e639-e650. Epub 2020 Nov 2 doi: 10.1016/j.wneu.2020.10.147. PMID: 33152495
Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG).
Gwak HS, Park HJ
Crit Rev Oncol Hematol 2017 Dec;120:111-119. Epub 2017 Oct 31 doi: 10.1016/j.critrevonc.2017.10.013. PMID: 29198324
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Adult brainstem gliomas.
Landolfi JC, Thaler HT, DeAngelis LM
Neurology 1998 Oct;51(4):1136-9. doi: 10.1212/wnl.51.4.1136. PMID: 9781543

Clinical prediction guides

Mutational landscape of primary spinal cord astrocytoma.
Cheng L, Zhang F, Zhao X, Wang L, Duan W, Guan J, Wang K, Liu Z, Wang X, Wang Z, Wu H, Chen Z, Teng L, Li Y, Xiao F, Fan T, Jian F
J Pathol 2023 Jul;260(3):317-328. Epub 2023 Apr 28 doi: 10.1002/path.6084. PMID: 37114614
Prediction of Cancer-Specific Survival of Brainstem Glioma in Children Based on Risk Stratification Model.
Sun K, Xu M, Fei X, Wang H, Xu L, Xu R, Xu M
Comput Math Methods Med 2022;2022:3436631. Epub 2022 Jul 20 doi: 10.1155/2022/3436631. PMID: 35912147Free PMC Article
Prediction of H3K27M-mutant brainstem glioma by amide proton transfer-weighted imaging and its derived radiomics.
Zhuo Z, Qu L, Zhang P, Duan Y, Cheng D, Xu X, Sun T, Ding J, Xie C, Liu X, Haller S, Barkhof F, Zhang L, Liu Y
Eur J Nucl Med Mol Imaging 2021 Dec;48(13):4426-4436. Epub 2021 Jun 16 doi: 10.1007/s00259-021-05455-4. PMID: 34131804
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article
Adult brainstem gliomas.
Landolfi JC, Thaler HT, DeAngelis LM
Neurology 1998 Oct;51(4):1136-9. doi: 10.1212/wnl.51.4.1136. PMID: 9781543

Recent systematic reviews

Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma.
Ius T, Montemurro N, Lombardi G, Berardinelli J, Romano A, Barresi V, Cerretti G, Guarnera A, Tel A, Cavallo LM, Pasqualetti F, Feletti A
Crit Rev Oncol Hematol 2024 Apr;196:104261. Epub 2024 Feb 22 doi: 10.1016/j.critrevonc.2024.104261. PMID: 38395241
Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
The Prognostic Impact of Radiotherapy in Conjunction with Temozolomide in Diffuse Intrinsic Pontine Glioma: A Systematic Review and Meta-Analysis.
Shi S, Lu S, Jing X, Liao J, Li Q
World Neurosurg 2021 Apr;148:e565-e571. Epub 2021 Jan 19 doi: 10.1016/j.wneu.2021.01.024. PMID: 33476781
Brainstem gliomas in pregnancy: a systematic review†.
Rosen A, Anderson V, Bercovici E, Laperriere N, D'Souza R
J Matern Fetal Neonatal Med 2020 Aug;33(16):2841-2851. Epub 2019 Jan 7 doi: 10.1080/14767058.2018.1560410. PMID: 30563399
Radiotherapy for diffuse brainstem glioma in children and young adults.
Hu X, Fang Y, Hui X, Jv Y, You C
Cochrane Database Syst Rev 2016 Jun 27;2016(6):CD010439. doi: 10.1002/14651858.CD010439.pub2. PMID: 27378212Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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