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Metastatic carcinoma in the bone

MedGen UID:
195970
•Concept ID:
C0700110
•
Neoplastic Process
Synonyms: Metastatic Carcinoma in the Bone; metastatic carcinoma in the bone; Metastatic Carcinoma to the Bone; metastatic carcinoma to the bone
 
Monarch Initiative: MONDO:0024884

Definition

A carcinoma that has spread to the bone from another, primary anatomic site. Bone is one of the most frequent sites of metastatic carcinoma. Common sites of origin include lung, breast, and prostate. [from NCI]

Professional guidelines

PubMed

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
The Role of Targeted Therapy in the Management of Sinonasal Malignancies.
Kashat L, Le CH, Chiu AG
Otolaryngol Clin North Am 2017 Apr;50(2):443-455. doi: 10.1016/j.otc.2016.12.016. PMID: 28314406
Nanoparticles-Based Treatment for Bone Metastasis.
Saracino R, Luciano R, Battafarano G, Perrotta A, Muraca M, Del Fattore A
Curr Drug Targets 2016;17(3):303-10. doi: 10.2174/1389450116666150427154706. PMID: 25915486

Recent clinical studies

Etiology

Unclassified Oncocytic Renal Neoplasm with Rib and Liver Metastases: Metastatic Oncocytoma?
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Clinical features and outcomes of metastatic bone tumors of the pelvis.
Yang Q, Chen N, Fu W
J Int Med Res 2021 Jun;49(6):3000605211013152. doi: 10.1177/03000605211013152. PMID: 34154434Free PMC Article
The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease.
Turner CJ, Edwards CM
Curr Osteoporos Rep 2016 Oct;14(5):170-7. doi: 10.1007/s11914-016-0323-2. PMID: 27566487
Implications of bone metastases and the benefits of bone-targeted therapy.
Lipton A
Semin Oncol 2010 Oct;37 Suppl 2:S15-29. doi: 10.1053/j.seminoncol.2010.10.002. PMID: 21111244
Metastatic carcinoma of the long bones.
Riccio AI, Wodajo FM, Malawer M
Am Fam Physician 2007 Nov 15;76(10):1489-94. PMID: 18052014

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base.
Thompson LDR, Bishop JA
Head Neck Pathol 2022 Mar;16(1):1-18. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01406-5. PMID: 35312976Free PMC Article
Bone invasion by oral squamous cell carcinoma.
Král D, Pink R, Šašková L, Michálek J, Tvrdý P
Acta Chir Plast 2021 Fall;63(3):139-144. doi: 10.48095/ccachp2021139. PMID: 34814695
Acrometastases.
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
Acrometastases.
Bricout PB
J Natl Med Assoc 1981 Apr;73(4):325-9. PMID: 7218364Free PMC Article

Therapy

Targeting the BMP Pathway in Prostate Cancer Induced Bone Disease.
Straign DM, Ihle CL, Provera MD, Owens P
Front Endocrinol (Lausanne) 2021;12:769316. Epub 2021 Dec 10 doi: 10.3389/fendo.2021.769316. PMID: 34956082Free PMC Article
Treatment and trials in non-metastatic castration-resistant prostate cancer.
Lokeshwar SD, Klaassen Z, Saad F
Nat Rev Urol 2021 Jul;18(7):433-442. Epub 2021 May 17 doi: 10.1038/s41585-021-00470-4. PMID: 34002069
The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease.
Turner CJ, Edwards CM
Curr Osteoporos Rep 2016 Oct;14(5):170-7. doi: 10.1007/s11914-016-0323-2. PMID: 27566487
Implications of bone metastases and the benefits of bone-targeted therapy.
Lipton A
Semin Oncol 2010 Oct;37 Suppl 2:S15-29. doi: 10.1053/j.seminoncol.2010.10.002. PMID: 21111244
Carcinoid tumors.
Boushey RP, Dackiw AP
Curr Treat Options Oncol 2002 Aug;3(4):319-26. doi: 10.1007/s11864-002-0031-2. PMID: 12074768

Prognosis

The Association Between Lymph Node Stage and Clinical Prognosis in Thyroid Cancer.
Zhang J, Cheng X, Shen L, Wang X, Wang L, Sun X, Qu S
Front Endocrinol (Lausanne) 2020;11:90. Epub 2020 Feb 27 doi: 10.3389/fendo.2020.00090. PMID: 32174889Free PMC Article
The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma.
Yoshida S, Shimo T, Murase Y, Takabatake K, Kishimoto K, Ibaragi S, Yoshioka N, Okui T, Nagatsuka H, Sasaki A
Anticancer Res 2018 Feb;38(2):955-962. doi: 10.21873/anticanres.12309. PMID: 29374727
Muscle metastasis of carcinoma.
Molina-Garrido MJ, Guillén-Ponce C
Clin Transl Oncol 2011 Feb;13(2):98-101. doi: 10.1007/s12094-011-0625-x. PMID: 21324797
Primary bone lymphoma.
Bhagavathi S, Fu K
Arch Pathol Lab Med 2009 Nov;133(11):1868-71. doi: 10.5858/133.11.1868. PMID: 19886726
Sarcoma and metastatic carcinoma.
Wolf RE
J Surg Oncol 2000 Jan;73(1):39-46. doi: 10.1002/(sici)1096-9098(200001)73:1<39::aid-jso11>3.0.co;2-q. PMID: 10649279

Clinical prediction guides

Ameloblastic carcinoma: A systematic review.
Robinson L, Abreu LG, Fonseca FP, Hunter KD, Ambele MA, van Heerden WFP
J Oral Pathol Med 2024 Mar;53(3):174-181. Epub 2024 Feb 18 doi: 10.1111/jop.13517. PMID: 38368851
Metastatic Renal Cell Carcinoma to the Spine: Outcomes and Morbidity: Single-Center Experience.
Park BJ, Seaman SC, Noeller JL, Smith MC, Hasan DM, Yasin H, Hitchon PW
World Neurosurg 2021 Oct;154:e398-e405. Epub 2021 Jul 17 doi: 10.1016/j.wneu.2021.07.041. PMID: 34280537
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF
Cancer Lett 2021 Nov 1;520:80-90. Epub 2021 Jul 4 doi: 10.1016/j.canlet.2021.06.030. PMID: 34233150Free PMC Article
Surgical treatment in bone metastases in the appendicular skeleton.
Clara-Altamirano MA, Garcia-Ortega DY, Martinez-Said H, Caro-Sánchez CHS, Herrera-Gomez A, Cuellar-Hubbe M
Rev Esp Cir Ortop Traumatol (Engl Ed) 2018 May-Jun;62(3):185-189. Epub 2018 Mar 21 doi: 10.1016/j.recot.2017.12.001. PMID: 29574162
Metastatic bone disease: A review of survival, prognostic factors and outcomes following surgical treatment of the appendicular skeleton.
Kirkinis MN, Lyne CJ, Wilson MD, Choong PF
Eur J Surg Oncol 2016 Dec;42(12):1787-1797. Epub 2016 Apr 19 doi: 10.1016/j.ejso.2016.03.036. PMID: 27499111

Recent systematic reviews

Ameloblastic carcinoma: A systematic review.
Robinson L, Abreu LG, Fonseca FP, Hunter KD, Ambele MA, van Heerden WFP
J Oral Pathol Med 2024 Mar;53(3):174-181. Epub 2024 Feb 18 doi: 10.1111/jop.13517. PMID: 38368851
Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Acrometastases to the Hand: A Systematic Review.
Umana GE, Scalia G, Palmisciano P, Passanisi M, Da Ros V, Pompili G, Barone F, Amico P, Tomasi SO, Graziano F, Patti IV, Mele S, Maugeri R, Raffa G, Giammalva GR, Iacopino GD, Germanò A, Nicoletti GF, Ippolito M, Sabini MG, Cicero S, Strigari L, Cuttone G
Medicina (Kaunas) 2021 Sep 9;57(9) doi: 10.3390/medicina57090950. PMID: 34577873Free PMC Article
Systematic review of site distribution of bone metastases in differentiated thyroid cancer.
Osorio M, Moubayed SP, Su H, Urken ML
Head Neck 2017 Apr;39(4):812-818. Epub 2017 Jan 11 doi: 10.1002/hed.24655. PMID: 28079945
Metastasis therapies for renal cancer.
Dabestani S, Marconi L, Bex A
Curr Opin Urol 2016 Nov;26(6):566-72. doi: 10.1097/MOU.0000000000000330. PMID: 27471993

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