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Ejection Fraction Decreased

MedGen UID:
196649
•Concept ID:
C0743400
•
Finding
Synonyms: Decreased ejection fraction; Ejection fraction decreased

Definition

A finding indicating a decrease in the volume of blood ejected during ventricular heart contraction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEjection Fraction Decreased

Professional guidelines

PubMed

Evolving Management Paradigm for Stable Ischemic Heart Disease Patients: JACC Review Topic of the Week.
Boden WE, Marzilli M, Crea F, Mancini GBJ, Weintraub WS, Taqueti VR, Pepine CJ, Escaned J, Al-Lamee R, Gowdak LHW, Berry C, Kaski JC; Chronic Myocardial Ischemic Syndromes Task Force
J Am Coll Cardiol 2023 Feb 7;81(5):505-514. doi: 10.1016/j.jacc.2022.08.814. PMID: 36725179Free PMC Article
HER2+ breast cancer treatment and cardiotoxicity: monitoring and management.
Jerusalem G, Lancellotti P, Kim SB
Breast Cancer Res Treat 2019 Sep;177(2):237-250. Epub 2019 Jun 5 doi: 10.1007/s10549-019-05303-y. PMID: 31165940Free PMC Article
Cardioembolic stroke: practical considerations for patient risk management and secondary prevention.
Amin H, Nowak RJ, Schindler JL
Postgrad Med 2014 Jan;126(1):55-65. doi: 10.3810/pgm.2014.01.2725. PMID: 24393752

Recent clinical studies

Etiology

A comprehensive echocardiographic analysis during simulated hypovolaemia: An observational study.
Feldheiser A, Juhl-Olsen P, Nordine M, Stetzuhn M, Wiegank L, Knebel F, Treskatsch S, Berger C
Eur J Anaesthesiol 2023 Aug 1;40(8):578-586. Epub 2023 Jun 1 doi: 10.1097/EJA.0000000000001863. PMID: 37265333
Dimensionless Index in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Ejection Fraction.
Altes A, Thellier N, Rusinaru D, Marsou W, Bohbot Y, Chadha G, Leman B, Paquet P, Ennezat PV, Tribouilloy C, Maréchaux S
Circ Cardiovasc Imaging 2020 Oct;13(10):e010925. Epub 2020 Oct 20 doi: 10.1161/CIRCIMAGING.120.010925. PMID: 33076698
Acellular Human Amniotic Membrane Scaffold with 15d-PGJ(2) Nanoparticles in Postinfarct Rat Model.
Francisco JC, Uemura L, Simeoni RB, da Cunha RC, Mogharbel BF, Simeoni PRB, Naves G, Napimoga MH, Noronha L, Carvalho KAT, Moreira LFP, Guarita-Souza LC
Tissue Eng Part A 2020 Nov;26(21-22):1128-1137. Epub 2020 Aug 18 doi: 10.1089/ten.TEA.2019.0340. PMID: 32486914
Factors associated with abnormal left ventricular ejection fraction (decreased or increased) in patients with sepsis in the intensive care unit.
Shin DG, Kang MK, Seo YB, Choi J, Choi SY, Choi S, Cho JR, Lee N
PLoS One 2020;15(3):e0229563. Epub 2020 Mar 10 doi: 10.1371/journal.pone.0229563. PMID: 32155161Free PMC Article
Plasticity of left ventricular function with cardiac resynchronization therapy.
Niu HX, Hu YR, Hua W, Gu M, Wang J, Gold MR, Zhang S
J Interv Card Electrophysiol 2020 Mar;57(2):289-294. Epub 2019 May 28 doi: 10.1007/s10840-019-00562-7. PMID: 31140043

Diagnosis

External validation and comparison of CHA(2)DS(2)-VASc-RAF and CHA(2)DS(2)-VASc-LAF scores for predicting left atrial thrombus and spontaneous echo contrast in patients with non-valvular atrial fibrillation.
Zheng N, Zhang J
J Interv Card Electrophysiol 2022 Nov;65(2):535-542. Epub 2022 Jul 13 doi: 10.1007/s10840-022-01285-y. PMID: 35831771
Serial Assessment of Right Ventricular Deformation in Patients With Hypoplastic Left Heart Syndrome: A Cardiovascular Magnetic Resonance Feature Tracking Study.
Kanngiesser LM, Freitag-Wolf S, Boroni Grazioli S, Gabbert DD, Hansen JH, Uebing AS, Voges I
J Am Heart Assoc 2022 May 3;11(9):e025332. Epub 2022 Apr 27 doi: 10.1161/JAHA.122.025332. PMID: 35475354Free PMC Article
Dimensionless Index in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Ejection Fraction.
Altes A, Thellier N, Rusinaru D, Marsou W, Bohbot Y, Chadha G, Leman B, Paquet P, Ennezat PV, Tribouilloy C, Maréchaux S
Circ Cardiovasc Imaging 2020 Oct;13(10):e010925. Epub 2020 Oct 20 doi: 10.1161/CIRCIMAGING.120.010925. PMID: 33076698
Factors associated with abnormal left ventricular ejection fraction (decreased or increased) in patients with sepsis in the intensive care unit.
Shin DG, Kang MK, Seo YB, Choi J, Choi SY, Choi S, Cho JR, Lee N
PLoS One 2020;15(3):e0229563. Epub 2020 Mar 10 doi: 10.1371/journal.pone.0229563. PMID: 32155161Free PMC Article
Cardiac dysfunction in cirrhosis - does adrenal function play a role? A hypothesis.
Theocharidou E, Krag A, Bendtsen F, Møller S, Burroughs AK
Liver Int 2012 Oct;32(9):1327-32. Epub 2012 Jan 31 doi: 10.1111/j.1478-3231.2011.02751.x. PMID: 22292920

Therapy

A disproportionality analysis of adverse events associated to pertuzumab in the FDA Adverse Event Reporting System (FAERS).
Zou SP, Yang HY, Ouyang ML, Cheng Q, Shi X, Sun MH
BMC Pharmacol Toxicol 2023 Nov 13;24(1):62. doi: 10.1186/s40360-023-00702-w. PMID: 37957717Free PMC Article
A comprehensive echocardiographic analysis during simulated hypovolaemia: An observational study.
Feldheiser A, Juhl-Olsen P, Nordine M, Stetzuhn M, Wiegank L, Knebel F, Treskatsch S, Berger C
Eur J Anaesthesiol 2023 Aug 1;40(8):578-586. Epub 2023 Jun 1 doi: 10.1097/EJA.0000000000001863. PMID: 37265333
Long-term outcomes after aortic valve replacement using a 19-mm bioprosthesis.
Okamura H, Kusadokoro S, Mieno M, Kimura N, Yamaguchi A
Eur J Cardiothorac Surg 2022 Feb 18;61(3):625-634. doi: 10.1093/ejcts/ezab379. PMID: 34431991
Acellular Human Amniotic Membrane Scaffold with 15d-PGJ(2) Nanoparticles in Postinfarct Rat Model.
Francisco JC, Uemura L, Simeoni RB, da Cunha RC, Mogharbel BF, Simeoni PRB, Naves G, Napimoga MH, Noronha L, Carvalho KAT, Moreira LFP, Guarita-Souza LC
Tissue Eng Part A 2020 Nov;26(21-22):1128-1137. Epub 2020 Aug 18 doi: 10.1089/ten.TEA.2019.0340. PMID: 32486914
Case report and review of the literature: the utilisation of a ventricular assist device as bridge to recovery for anthracycline-induced ventricular dysfunction.
Krasnopero D, Asante-Korang A, Jacobs JP, Stapleton S, Carapellucci J, Dotson M, Stapleton G
Cardiol Young 2018 Mar;28(3):471-475. Epub 2017 Dec 4 doi: 10.1017/S1047951117002281. PMID: 29198224

Prognosis

Variations in serum low-density lipoprotein and sST2 among heart failure patients with different ejection fraction groups and their clinical significance.
Liu Y, Gao L, Zhao G, Zhang W, Du C, Sun W, Jin L, Lu H, Zhou H
Medicine (Baltimore) 2024 Mar 1;103(9):e37357. doi: 10.1097/MD.0000000000037357. PMID: 38428890Free PMC Article
External validation and comparison of CHA(2)DS(2)-VASc-RAF and CHA(2)DS(2)-VASc-LAF scores for predicting left atrial thrombus and spontaneous echo contrast in patients with non-valvular atrial fibrillation.
Zheng N, Zhang J
J Interv Card Electrophysiol 2022 Nov;65(2):535-542. Epub 2022 Jul 13 doi: 10.1007/s10840-022-01285-y. PMID: 35831771
Serial Assessment of Right Ventricular Deformation in Patients With Hypoplastic Left Heart Syndrome: A Cardiovascular Magnetic Resonance Feature Tracking Study.
Kanngiesser LM, Freitag-Wolf S, Boroni Grazioli S, Gabbert DD, Hansen JH, Uebing AS, Voges I
J Am Heart Assoc 2022 May 3;11(9):e025332. Epub 2022 Apr 27 doi: 10.1161/JAHA.122.025332. PMID: 35475354Free PMC Article
Dimensionless Index in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Ejection Fraction.
Altes A, Thellier N, Rusinaru D, Marsou W, Bohbot Y, Chadha G, Leman B, Paquet P, Ennezat PV, Tribouilloy C, Maréchaux S
Circ Cardiovasc Imaging 2020 Oct;13(10):e010925. Epub 2020 Oct 20 doi: 10.1161/CIRCIMAGING.120.010925. PMID: 33076698
Trends in long-term prognosis according to left ventricular ejection fraction after acute coronary syndrome.
Yahud E, Tzuman O, Fink N, Goldenberg I, Goldkorn R, Peled Y, Lev E, Asher E
J Cardiol 2020 Sep;76(3):303-308. Epub 2020 Apr 22 doi: 10.1016/j.jjcc.2020.03.012. PMID: 32334901

Clinical prediction guides

A comprehensive echocardiographic analysis during simulated hypovolaemia: An observational study.
Feldheiser A, Juhl-Olsen P, Nordine M, Stetzuhn M, Wiegank L, Knebel F, Treskatsch S, Berger C
Eur J Anaesthesiol 2023 Aug 1;40(8):578-586. Epub 2023 Jun 1 doi: 10.1097/EJA.0000000000001863. PMID: 37265333
External validation and comparison of CHA(2)DS(2)-VASc-RAF and CHA(2)DS(2)-VASc-LAF scores for predicting left atrial thrombus and spontaneous echo contrast in patients with non-valvular atrial fibrillation.
Zheng N, Zhang J
J Interv Card Electrophysiol 2022 Nov;65(2):535-542. Epub 2022 Jul 13 doi: 10.1007/s10840-022-01285-y. PMID: 35831771
Serial Assessment of Right Ventricular Deformation in Patients With Hypoplastic Left Heart Syndrome: A Cardiovascular Magnetic Resonance Feature Tracking Study.
Kanngiesser LM, Freitag-Wolf S, Boroni Grazioli S, Gabbert DD, Hansen JH, Uebing AS, Voges I
J Am Heart Assoc 2022 May 3;11(9):e025332. Epub 2022 Apr 27 doi: 10.1161/JAHA.122.025332. PMID: 35475354Free PMC Article
Long-term outcomes after aortic valve replacement using a 19-mm bioprosthesis.
Okamura H, Kusadokoro S, Mieno M, Kimura N, Yamaguchi A
Eur J Cardiothorac Surg 2022 Feb 18;61(3):625-634. doi: 10.1093/ejcts/ezab379. PMID: 34431991
Dimensionless Index in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Ejection Fraction.
Altes A, Thellier N, Rusinaru D, Marsou W, Bohbot Y, Chadha G, Leman B, Paquet P, Ennezat PV, Tribouilloy C, Maréchaux S
Circ Cardiovasc Imaging 2020 Oct;13(10):e010925. Epub 2020 Oct 20 doi: 10.1161/CIRCIMAGING.120.010925. PMID: 33076698

Recent systematic reviews

Prevalence and determinants of return to work after various coronary events: meta-analysis of prospective studies.
Kai SHY, Ferrières J, Rossignol M, Bouisset F, Herry J, Esquirol Y
Sci Rep 2022 Sep 12;12(1):15348. doi: 10.1038/s41598-022-19467-z. PMID: 36097026Free PMC Article
Efficacy and safety of low dose ticagrelor in patients with acute coronary syndrome: a systematic review and meta-analysis.
Chen Q, Zhang Y, Wang Z, Wang S, Zhang H, Wang Y, Lu C, Xuan H, Wang C, Li D, Xu T
Postgrad Med J 2020 Nov;96(1141):693-702. Epub 2020 Jun 19 doi: 10.1136/postgradmedj-2019-137180. PMID: 32561595

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