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Rheumatoid nodulosis

MedGen UID:
19781
•Concept ID:
C0035450
•
Acquired Abnormality
Synonyms: Nodule, Rheumatoid; Nodules, Rheumatoid; Rheumatoid Nodule; Rheumatoid Nodules; Rheumatoid Noduloses; Rheumatoid Nodulosis
SNOMED CT: Rheumatoid nodulosis (402426007); Rheumatoid nodule (201789001); Subcutaneous rheumatoid nodule (33719002); Rheumatoid nodule (50782009)
 
Monarch Initiative: MONDO:0008384
OMIM®: 180350

Definition

A well circumscribed lump of tissue, firm to touch, typically non-tender, predominantly occurring as a cutaneous manifestation of rheumatoid arthritis localized to extensor surfaces near joints, but may be internal. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatoid nodulosis

Professional guidelines

PubMed

2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
Berkun Y, Abou Atta I, Rubinow A, Orbach H, Levartovsky D, Aamar S, Arbel O, Dresner-Pollak R, Friedman G, Ben-Yehuda A
J Rheumatol 2007 Aug;34(8):1664-9. Epub 2007 Jul 1 PMID: 17611986

Recent clinical studies

Etiology

Granulomatous Cutaneous Drug Eruptions: A Systematic Review.
Shah N, Shah M, Drucker AM, Shear NH, Ziv M, Dodiuk-Gad RP
Am J Clin Dermatol 2021 Jan;22(1):39-53. doi: 10.1007/s40257-020-00566-4. PMID: 33108647
Clinicopathologic features of rheumatoid nodules: a retrospective analysis.
Bang S, Kim Y, Jang K, Paik SS, Shin SJ
Clin Rheumatol 2019 Nov;38(11):3041-3048. Epub 2019 Jul 4 doi: 10.1007/s10067-019-04668-1. PMID: 31273637
Bilateral epibulbar pseudorheumatoid nodulosis with a review of ocular adnexal palisading granulomas.
Tieger MG, Jakobiec FA, Wolkow N, Ma L, Chang HP
Surv Ophthalmol 2019 Jul-Aug;64(4):558-569. Epub 2019 Feb 14 doi: 10.1016/j.survophthal.2019.02.002. PMID: 30772365
Granulomatous Drug Eruptions.
Dodiuk-Gad RP, Shear NH
Dermatol Clin 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015. PMID: 26143430
Benign rheumatoid nodulosis.
Guidelli GM, Garcia-Gonzalez E, Selvi E
Joint Bone Spine 2015 Oct;82(5):370. Epub 2015 Mar 13 doi: 10.1016/j.jbspin.2015.01.009. PMID: 25776448

Diagnosis

Skin manifestations of rheumatoid arthritis.
Lora V, Cerroni L, Cota C
G Ital Dermatol Venereol 2018 Apr;153(2):243-255. Epub 2018 Jan 24 doi: 10.23736/S0392-0488.18.05872-8. PMID: 29368864
Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides.
Chua-Aguilera CJ, Möller B, Yawalkar N
Clin Rev Allergy Immunol 2017 Dec;53(3):371-393. doi: 10.1007/s12016-017-8632-5. PMID: 28752373
Granulomatous Drug Eruptions.
Dodiuk-Gad RP, Shear NH
Dermatol Clin 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015. PMID: 26143430
Rheumatoid nodule.
García-Patos V
Semin Cutan Med Surg 2007 Jun;26(2):100-7. doi: 10.1016/j.sder.2007.02.007. PMID: 17544962
Rheumatoid arthritis: a review of the cutaneous manifestations.
Sayah A, English JC 3rd
J Am Acad Dermatol 2005 Aug;53(2):191-209; quiz 210-2. doi: 10.1016/j.jaad.2004.07.023. PMID: 16021111

Therapy

Granulomatous Cutaneous Drug Eruptions: A Systematic Review.
Shah N, Shah M, Drucker AM, Shear NH, Ziv M, Dodiuk-Gad RP
Am J Clin Dermatol 2021 Jan;22(1):39-53. doi: 10.1007/s40257-020-00566-4. PMID: 33108647
Methotrexate-Induced Acute Rheumatoid Nodulosis in Liver and Spleen Imitating Metastatic Malignancy.
Kosmidou M, Papamichail G, Milionis H
J Clin Rheumatol 2021 Dec 1;27(8S):S747-S748. doi: 10.1097/RHU.0000000000001519. PMID: 32826660
Skin manifestations of rheumatoid arthritis.
Lora V, Cerroni L, Cota C
G Ital Dermatol Venereol 2018 Apr;153(2):243-255. Epub 2018 Jan 24 doi: 10.23736/S0392-0488.18.05872-8. PMID: 29368864
Granulomatous Drug Eruptions.
Dodiuk-Gad RP, Shear NH
Dermatol Clin 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015. PMID: 26143430
Benign rheumatoid nodulosis.
Guidelli GM, Garcia-Gonzalez E, Selvi E
Joint Bone Spine 2015 Oct;82(5):370. Epub 2015 Mar 13 doi: 10.1016/j.jbspin.2015.01.009. PMID: 25776448

Prognosis

Benign rheumatoid nodulosis.
Guidelli GM, Garcia-Gonzalez E, Selvi E
Joint Bone Spine 2015 Oct;82(5):370. Epub 2015 Mar 13 doi: 10.1016/j.jbspin.2015.01.009. PMID: 25776448
Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions.
Hawryluk EB, Izikson L, English JC 3rd
Am J Clin Dermatol 2010;11(3):171-81. doi: 10.2165/11530080-000000000-00000. PMID: 20184390
Rheumatoid nodule.
García-Patos V
Semin Cutan Med Surg 2007 Jun;26(2):100-7. doi: 10.1016/j.sder.2007.02.007. PMID: 17544962
Rheumatoid nodulosis: report of two new cases and discussion of diagnostic criteria.
Couret M, Combe B, Chuong VT, Leroux JL, Blotman F, Sany J
J Rheumatol 1988 Sep;15(9):1427-30. PMID: 3058975
Rheumatoid nodulosis of the hand.
Fleischer A, McGrath MH
J Hand Surg Am 1984 May;9(3):404-11. doi: 10.1016/s0363-5023(84)80232-4. PMID: 6725901

Clinical prediction guides

Clinicopathologic features of rheumatoid nodules: a retrospective analysis.
Bang S, Kim Y, Jang K, Paik SS, Shin SJ
Clin Rheumatol 2019 Nov;38(11):3041-3048. Epub 2019 Jul 4 doi: 10.1007/s10067-019-04668-1. PMID: 31273637
Rheumatoid nodulosis with extra-articular cyst synovitis.
Dhaon P, Das S, Sharma A, Wakhlu A, Goel MM
Int J Rheum Dis 2015 Nov;18(8):906-7. Epub 2015 Aug 18 doi: 10.1111/1756-185X.12733. PMID: 26284464
Occurrence of pulmonary rheumatoid nodules following biological therapies.
Kovács A, Baksay B, Cserenyecz A, Molnár K, Takács M, Szekanecz Z
Clin Rheumatol 2015 Sep;34(9):1639-42. Epub 2014 Sep 30 doi: 10.1007/s10067-014-2789-6. PMID: 25267563
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
Berkun Y, Abou Atta I, Rubinow A, Orbach H, Levartovsky D, Aamar S, Arbel O, Dresner-Pollak R, Friedman G, Ben-Yehuda A
J Rheumatol 2007 Aug;34(8):1664-9. Epub 2007 Jul 1 PMID: 17611986
HLA DRB1* alleles in rheumatoid nodulosis: a comparative study with rheumatoid arthritis with and without nodules.
Toussirot E, Tiberghien P, Balblanc JC, Kremer P, Despaux J, Dupond JL, Wendling D
Rheumatol Int 1998;17(6):233-6. doi: 10.1007/s002960050040. PMID: 9592863

Recent systematic reviews

Granulomatous Cutaneous Drug Eruptions: A Systematic Review.
Shah N, Shah M, Drucker AM, Shear NH, Ziv M, Dodiuk-Gad RP
Am J Clin Dermatol 2021 Jan;22(1):39-53. doi: 10.1007/s40257-020-00566-4. PMID: 33108647

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