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Rhinoscleroma

MedGen UID:
20569
•Concept ID:
C0035468
•
Disease or Syndrome
Synonym: Scleroma, Nasal
SNOMED CT: Rhinoscleroma (72409005); Infection by Klebsiella rhinoscleromatis (72409005); Scleroma (72409005)
 
Monarch Initiative: MONDO:0005945

Definition

A granulomatous disease caused by klebsiella rhinoscleromatis infection. Despite its name, this disease is not limited to the nose and nasopharynx but may affect any part of the respiratory tract, sometimes with extension to the lip and the skin. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRhinoscleroma

Professional guidelines

PubMed

Topical ciprofloxacin as treatment for rhinoscleroma in a series of 23 patients.
Gamea M, El Tatawi F, Elnaggar A, Elafandi H, Ebeid K
Clin Otolaryngol 2021 Jul;46(4):893-896. Epub 2021 Mar 10 doi: 10.1111/coa.13747. PMID: 33650263
Granulomatous disease in the head and neck: developing a differential diagnosis.
Nwawka OK, Nadgir R, Fujita A, Sakai O
Radiographics 2014 Sep-Oct;34(5):1240-56. doi: 10.1148/rg.345130068. PMID: 25208278
The management of rhinoscleroma.
Ssali CL
J Laryngol Otol 1975 Jan;89(1):91-9. doi: 10.1017/s0022215100080117. PMID: 1089741

Recent clinical studies

Etiology

Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Airway scleromas and their extensions.
Molumi CP, Dubey SP
ANZ J Surg 2016 Sep;86(9):670-4. Epub 2015 May 26 doi: 10.1111/ans.13183. PMID: 26011421
Rhinoscleroma: a detailed histopathological diagnostic insight.
Ahmed AR, El-Badawy ZH, Mohamed IR, Abdelhameed WA
Int J Clin Exp Pathol 2015;8(7):8438-45. Epub 2015 Jul 1 PMID: 26339415Free PMC Article
Granulomatous disorders of the nose and paranasal sinuses.
Fuchs HA, Tanner SB
Curr Opin Otolaryngol Head Neck Surg 2009 Feb;17(1):23-7. doi: 10.1097/MOO.0b013e32831b9e58. PMID: 19225301
Laryngeal scleroma.
Fajardo-Dolci G, Chavolla R, Lamadrid-Bautista E, Rizo-Alvarez J
J Otolaryngol 1999 Aug;28(4):229-31. PMID: 10461261

Diagnosis

Tracheal rhinoscleroma.
Bigi A, Bartolomeo M, Costes V, Makeieff M
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):51-3. Epub 2016 Jan 4 doi: 10.1016/j.anorl.2015.03.009. PMID: 26769262
Rhinoschleroma.
Cataño JC, Gallego S
Am J Trop Med Hyg 2015 Jan;92(1):3. doi: 10.4269/ajtmh.14-0288. PMID: 25568179Free PMC Article
Rhinoscleroma of the sinuses.
Bailhache A, Dehesdin D, François A, Marie JP, Choussy O
Rhinology 2008 Dec;46(4):338-41. PMID: 19146007
Rhinoscleroma.
The Editors
J Med Microbiol 2000 May;49(5):395-396. doi: 10.1099/0022-1317-49-5-395. PMID: 10798549
Rhinoscleroma.
Lenis A, Ruff T, Diaz JA, Ghandour EG
South Med J 1988 Dec;81(12):1580-2. doi: 10.1097/00007611-198812000-00029. PMID: 3059525

Therapy

Rhinoscleroma.
Umphress B, Raparia K
Arch Pathol Lab Med 2018 Dec;142(12):1533-1536. Epub 2018 Aug 31 doi: 10.5858/arpa.2018-0073-RA. PMID: 30168726
Tracheal rhinoscleroma.
Bigi A, Bartolomeo M, Costes V, Makeieff M
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):51-3. Epub 2016 Jan 4 doi: 10.1016/j.anorl.2015.03.009. PMID: 26769262
Coexistence of rhinoscleroma with Rosai-Dorfman disease: is rhinoscleroma a cause of this disease?
Kumari JO
J Laryngol Otol 2012 Jun;126(6):630-2. doi: 10.1017/S0022215112000552. PMID: 22643208
Nonneoplastic lesions of the tracheobronchial wall: radiologic findings with bronchoscopic correlation.
Prince JS, Duhamel DR, Levin DL, Harrell JH, Friedman PJ
Radiographics 2002 Oct;22 Spec No:S215-30. doi: 10.1148/radiographics.22.suppl_1.g02oc02s215. PMID: 12376612
Rhinoscleroma.
Lenis A, Ruff T, Diaz JA, Ghandour EG
South Med J 1988 Dec;81(12):1580-2. doi: 10.1097/00007611-198812000-00029. PMID: 3059525

Prognosis

Correlation Between Nasal and Laryngeal Lesions of Rhinoscleroma in Patients of Upper Egypt.
Awad O, Zaky E, Talaat M
J Voice 2022 Jul;36(4):587.e13-587.e20. Epub 2020 Aug 19 doi: 10.1016/j.jvoice.2020.07.017. PMID: 32826120
A Myriad of Scleroma Presentations: The Usual and Unusual.
Elwany S, Fattah HA, Mandour Z, Ismail AS, Abdelnabi M
Head Neck Pathol 2020 Sep;14(3):588-592. Epub 2019 Sep 16 doi: 10.1007/s12105-019-01075-5. PMID: 31529285Free PMC Article
Airway scleromas and their extensions.
Molumi CP, Dubey SP
ANZ J Surg 2016 Sep;86(9):670-4. Epub 2015 May 26 doi: 10.1111/ans.13183. PMID: 26011421
Granulomatous disorders of the nose and paranasal sinuses.
Fuchs HA, Tanner SB
Curr Opin Otolaryngol Head Neck Surg 2009 Feb;17(1):23-7. doi: 10.1097/MOO.0b013e32831b9e58. PMID: 19225301
Rhinoscleroma: case report.
Simons ME, Granato L, Oliveira RC, Alcantara MP
Braz J Otorhinolaryngol 2006 Jul-Aug;72(4):568-71. doi: 10.1016/s1808-8694(15)31006-5. PMID: 17143439Free PMC Article

Clinical prediction guides

Correlation Between Nasal and Laryngeal Lesions of Rhinoscleroma in Patients of Upper Egypt.
Awad O, Zaky E, Talaat M
J Voice 2022 Jul;36(4):587.e13-587.e20. Epub 2020 Aug 19 doi: 10.1016/j.jvoice.2020.07.017. PMID: 32826120
Tracheal rhinoscleroma.
Bigi A, Bartolomeo M, Costes V, Makeieff M
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):51-3. Epub 2016 Jan 4 doi: 10.1016/j.anorl.2015.03.009. PMID: 26769262
Rhinoscleroma: a detailed histopathological diagnostic insight.
Ahmed AR, El-Badawy ZH, Mohamed IR, Abdelhameed WA
Int J Clin Exp Pathol 2015;8(7):8438-45. Epub 2015 Jul 1 PMID: 26339415Free PMC Article
Rhinoschleroma.
Cataño JC, Gallego S
Am J Trop Med Hyg 2015 Jan;92(1):3. doi: 10.4269/ajtmh.14-0288. PMID: 25568179Free PMC Article
Rhinoscleroma: a retrospective study of pathologic and clinical features.
Zhong Q, Guo W, Chen X, Ni X, Fang J, Huang Z, Zhang S
J Otolaryngol Head Neck Surg 2011 Apr;40(2):167-74. PMID: 21453653

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