U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stage 4S Neuroblastoma

MedGen UID:
210046
Concept ID:
C1135161
Neoplastic Process
Synonyms: Neuroblastoma Stage IVS; Neuroblastoma, metastatic; Pepper's Syndrome; Stage IVS Neuroblastoma
SNOMED CT: Neuroblastoma, metastatic (704147007)

Definition

Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Peyam S, Bansal D
Indian J Pediatr 2023 Mar;90(3):213-214. Epub 2023 Jan 25 doi: 10.1007/s12098-023-04477-0. PMID: 36696002
Anand S, Agarwala S, Jain V, Dhua A, Bakhshi S, Jana M, Kandasamy D, Biswas A
Indian J Pediatr 2023 Mar;90(3):220-226. Epub 2022 Sep 16 doi: 10.1007/s12098-022-04341-7. PMID: 36112265
Weintraub M, Waldman E, Koplewitz B, Bloom AI, Gross E, Freeman AI, Revel-Vilk S
Pediatr Blood Cancer 2012 Jul 15;59(1):182-4. Epub 2011 May 16 doi: 10.1002/pbc.23186. PMID: 22605456

Recent clinical studies

Etiology

Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Kawano A, Hazard FK, Chiu B, Naranjo A, LaBarre B, London WB, Hogarty MD, Cohn SL, Maris JM, Park JR, Gastier-Foster JM, Ikegaki N, Shimada H
Am J Surg Pathol 2021 Aug 1;45(8):1075-1081. doi: 10.1097/PAS.0000000000001647. PMID: 33739795Free PMC Article
Tas ML, Nagtegaal M, Kraal KCJM, Tytgat GAM, Abeling NGGM, Koster J, Pluijm SMF, Zwaan CM, de Keizer B, Molenaar JJ, van Noesel MM
Pediatr Blood Cancer 2020 Apr;67(4):e28061. Epub 2019 Nov 17 doi: 10.1002/pbc.28061. PMID: 31736229
Ozguven AA, Anak S, Unuvar A, Akcay A, Karakas Z, Ozturk G, Devecioglu O, Agaoğlu L
Indian J Pediatr 2015 May;82(5):450-7. Epub 2014 Oct 2 doi: 10.1007/s12098-014-1578-1. PMID: 25274444
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Diagnosis

Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Tas ML, Nagtegaal M, Kraal KCJM, Tytgat GAM, Abeling NGGM, Koster J, Pluijm SMF, Zwaan CM, de Keizer B, Molenaar JJ, van Noesel MM
Pediatr Blood Cancer 2020 Apr;67(4):e28061. Epub 2019 Nov 17 doi: 10.1002/pbc.28061. PMID: 31736229
Ozguven AA, Anak S, Unuvar A, Akcay A, Karakas Z, Ozturk G, Devecioglu O, Agaoğlu L
Indian J Pediatr 2015 May;82(5):450-7. Epub 2014 Oct 2 doi: 10.1007/s12098-014-1578-1. PMID: 25274444
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320
Matthay KK
J Clin Oncol 1998 Jun;16(6):2003-6. doi: 10.1200/JCO.1998.16.6.2003. PMID: 9626196

Therapy

Mubarak M, Singal AK, Gawdi A
Gulf J Oncolog 2019 May;1(30):81-84. PMID: 31242987
Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, Mattei P, Adkins ES, Shimada H, London WB, Park JR, Matthay KK, Maris JM
J Clin Oncol 2019 Jan 10;37(2):115-124. Epub 2018 Nov 16 doi: 10.1200/JCO.18.00419. PMID: 30444686Free PMC Article
Elimam NA, Atra AA, Fayea NY, Al-Asaad TG, Khattab TM, Al-Sulami GA, Felimban SK
Saudi Med J 2006 Nov;27(11):1734-6. PMID: 17106552
Schleiermacher G, Rubie H, Hartmann O, Bergeron C, Chastagner P, Mechinaud F, Michon J; Neuroblastoma Study Group of the French Society of Paediatric Oncology
Br J Cancer 2003 Aug 4;89(3):470-6. doi: 10.1038/sj.bjc.6601154. PMID: 12888814Free PMC Article
Roberts S, Creamer K, Shoupe B, Flores Y, Robie D
J Pediatr Hematol Oncol 2002 Feb;24(2):142-4. doi: 10.1097/00043426-200202000-00017. PMID: 11990702

Prognosis

Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Raitio A, Rice MJ, Mullassery D, Losty PD
Eur J Pediatr Surg 2021 Oct;31(5):385-389. Epub 2020 Sep 15 doi: 10.1055/s-0040-1716836. PMID: 32932540
Tas ML, Nagtegaal M, Kraal KCJM, Tytgat GAM, Abeling NGGM, Koster J, Pluijm SMF, Zwaan CM, de Keizer B, Molenaar JJ, van Noesel MM
Pediatr Blood Cancer 2020 Apr;67(4):e28061. Epub 2019 Nov 17 doi: 10.1002/pbc.28061. PMID: 31736229
Ozguven AA, Anak S, Unuvar A, Akcay A, Karakas Z, Ozturk G, Devecioglu O, Agaoğlu L
Indian J Pediatr 2015 May;82(5):450-7. Epub 2014 Oct 2 doi: 10.1007/s12098-014-1578-1. PMID: 25274444
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Clinical prediction guides

Anand S, Agarwala S, Jain V, Dhua A, Bakhshi S, Jana M, Kandasamy D, Biswas A
Indian J Pediatr 2023 Mar;90(3):220-226. Epub 2022 Sep 16 doi: 10.1007/s12098-022-04341-7. PMID: 36112265
Montalto S, Sertorio F, Podda M, Sorrentino S, Di Cataldo A, Provenzi M, Nonnis A, D'Ippolito C, Corrias MV, De Bernardi B
Pediatr Hematol Oncol 2022 Aug;39(5):441-452. Epub 2022 Feb 10 doi: 10.1080/08880018.2021.2013368. PMID: 35139733
Parodi S, Sorrentino S, Cataldo AD, Tondo A, Fagnani AM, Perri P, Gigliotti AR, Erminio G, Corrias MV, De Bernardi B
Pediatr Blood Cancer 2021 May;68(5):e28904. Epub 2021 Jan 18 doi: 10.1002/pbc.28904. PMID: 33459514
Raitio A, Rice MJ, Mullassery D, Losty PD
Eur J Pediatr Surg 2021 Oct;31(5):385-389. Epub 2020 Sep 15 doi: 10.1055/s-0040-1716836. PMID: 32932540
Tsubota S, Kadomatsu K
Cell Tissue Res 2018 May;372(2):211-221. Epub 2018 Feb 14 doi: 10.1007/s00441-018-2796-z. PMID: 29445860

Recent systematic reviews

Raitio A, Rice MJ, Mullassery D, Losty PD
Eur J Pediatr Surg 2021 Oct;31(5):385-389. Epub 2020 Sep 15 doi: 10.1055/s-0040-1716836. PMID: 32932540

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...