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Non-gestational choriocarcinoma

MedGen UID:
211656
•Concept ID:
C1135873
•
Neoplastic Process
Synonyms: Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational Choriocarcinoma; Non-gestational Choriocarcinoma; Non-gestational Choriocarcinomas
 
Monarch Initiative: MONDO:0006871

Definition

A highly malignant choriocarcinoma derived from the non-placental origin such as the totipotent cells in the testis, the ovary, and the pineal gland. It produces high levels of chorionic gonadotropin and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis. [from MONDO]

Professional guidelines

PubMed

Pulse actinomycin D as first-line treatment of low-risk post-molar non-choriocarcinoma gestational trophoblastic neoplasia.
Li L, Wan X, Feng F, Ren T, Yang J, Zhao J, Jiang F, Xiang Y
BMC Cancer 2018 May 23;18(1):585. doi: 10.1186/s12885-018-4512-5. PMID: 29792175Free PMC Article

Recent clinical studies

Etiology

Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors.
Moro F, Castellano LM, Franchi D, Epstein E, Fischerova D, Froyman W, Timmerman D, Zannoni GF, Scambia G, Valentin L, Testa AC, Mascilini F
Ultrasound Obstet Gynecol 2021 Jun;57(6):987-994. doi: 10.1002/uog.23529. PMID: 33142349
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases.
Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, Xiang Y
J Reprod Med 2014 May-Jun;59(5-6):221-6. PMID: 24937961
Molecular genetic analyses of choriocarcinoma.
Zhao J, Xiang Y, Wan XR, Feng FZ, Cui QC, Yang XY
Placenta 2009 Sep;30(9):816-20. Epub 2009 Jul 31 doi: 10.1016/j.placenta.2009.06.011. PMID: 19647314

Diagnosis

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Primary non-gestational mediastinal choriocarcinoma metastatic to the brainstem.
De Jesus O, Pellot Cestero JE, Gómez-González FM, Vélez R
BMJ Case Rep 2022 Apr 1;15(4) doi: 10.1136/bcr-2021-248389. PMID: 35365470Free PMC Article
Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation.
Payne T, Di Palma S, Walker D, Dakin J, Thompson LDR
Head Neck Pathol 2021 Sep;15(3):1047-1053. Epub 2020 Oct 31 doi: 10.1007/s12105-020-01245-w. PMID: 33128732Free PMC Article
Primary non-gestational uterine choriocarcinoma mimicking leiomyoma.
Sano R, Moriya T, Suzuki S, Saito W, Shimoya K, Shiota M
Pathol Int 2019 Mar;69(3):160-164. Epub 2019 Feb 18 doi: 10.1111/pin.12763. PMID: 30775828
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083

Therapy

Nongestational ovarian choriocarcinoma with bilateral teratoma: A rare case report and literature review.
Ao X, Hu S, Tan S, Xiong W
Medicine (Baltimore) 2024 May 3;103(18):e36996. doi: 10.1097/MD.0000000000036996. PMID: 38701311Free PMC Article
A rare case of primary rectal choriocarcinoma and review of the literature.
Telli TA, Demircan NC, Alan O, Tuylu TB, Arikan R, Ercelep O, Atıcı AE, Ergelen R, Seven IE, Babacan NA, Kaya S, Dane F, Fulden Yumuk P
J Oncol Pharm Pract 2020 Jun;26(4):989-994. Epub 2019 Sep 23 doi: 10.1177/1078155219875510. PMID: 31547751
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
A Young Female With Metastatic Nongestational Choriocarcinoma.
Yadav BS, Rai B, Suri V, Mukherjee KK, Bal A, Morgan R, Shonka NA, Lele S, Morris GJ
Semin Oncol 2015 Dec;42(6):e109-15. Epub 2015 Sep 24 doi: 10.1053/j.seminoncol.2015.09.021. PMID: 26615138
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases.
Liu Y, Yang J, Ren T, Zhao J, Feng F, Wan X, Xiang Y
J Reprod Med 2014 May-Jun;59(5-6):221-6. PMID: 24937961

Prognosis

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Pure nongestational uterine choriocarcinoma in postmenopausal women: a case report with literature review.
Wang L, Wan Y, Sun Y, Zhang X, Cheng X, Wu M, Liu G
Cancer Biol Ther 2019;20(9):1176-1182. Epub 2019 May 27 doi: 10.1080/15384047.2019.1617564. PMID: 31132027Free PMC Article
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083

Clinical prediction guides

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Clinical Experience of Male Primary Choriocarcinoma at the Samsung Medical Center.
Ji YS, Park SH
Cancer Res Treat 2021 Jul;53(3):874-880. Epub 2020 Dec 7 doi: 10.4143/crt.2020.1066. PMID: 33285049Free PMC Article
Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases.
Whaley RD, Dougherty RE, Cheng L, Ulbright TM
Arch Pathol Lab Med 2020 Jul 1;144(7):863-868. doi: 10.5858/arpa.2019-0207-OA. PMID: 31846368
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066

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