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Thyroid Gland Oncocytic Neoplasm

MedGen UID:
215387
•Concept ID:
C0949541
•
Neoplastic Process
Synonyms: Huerthle Cell Tumor; Hurthle Cell Tumor
SNOMED CT: Hurthle cell adenoma (89439007); Hurthle cell tumor (89439007); Hurthle cell neoplasm (363639001)

Definition

An adenoma or carcinoma arising from the follicular cells of the thyroid gland. It is composed of large oncocytic cells with abundant granular eosinophilic cytoplasm. [from NCI]

Professional guidelines

PubMed

Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors.
Jung CK, Kim Y, Jeon S, Jo K, Lee S, Bae JS
Hum Pathol 2018 Nov;81:9-17. Epub 2018 May 1 doi: 10.1016/j.humpath.2018.04.018. PMID: 29723601
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Unclassified Oncocytic Renal Neoplasm with Rib and Liver Metastases: Metastatic Oncocytoma?
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland.
Lubin D, Song S, Zafar HM, Baloch Z
Diagn Cytopathol 2019 Jun;47(6):617-636. Epub 2019 Mar 26 doi: 10.1002/dc.24175. PMID: 30912629
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Hürthle cell carcinoma.
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Diagnosis

Renal oncocytoma: a challenging diagnosis.
Mirkheshti N, Farrukh N, Legesse T, Rowe SP, Gordetsky J, Hussain A
Curr Opin Oncol 2022 May 1;34(3):243-252. doi: 10.1097/CCO.0000000000000829. PMID: 35671122
Unclassified Oncocytic Renal Neoplasm with Rib and Liver Metastases: Metastatic Oncocytoma?
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491

Therapy

Psammomatous calcifications in thyroid oncocytic (Hürthle cell) follicular tumors.
Ronen N, Suster D
Ann Diagn Pathol 2023 Feb;62:152061. Epub 2022 Nov 22 doi: 10.1016/j.anndiagpath.2022.152061. PMID: 36459776
Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
Poorly differentiated oncocytic thyroid carcinoma--diagnostic implications and outcome.
Dettmer M, Schmitt A, Steinert H, Moch H, Komminoth P, Perren A
Histopathology 2012 Jun;60(7):1045-51. Epub 2012 Feb 20 doi: 10.1111/j.1365-2559.2012.04188.x. PMID: 22348590
Management of invasive and advanced thyroid cancer.
Favia G, Iacobone M, Zanella S, Ciarleglio FA
Minerva Endocrinol 2009 Mar;34(1):37-55. PMID: 19209127
Hürthle cell carcinoma.
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Prognosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.
Grani G, Lamartina L, Durante C, Filetti S, Cooper DS
Lancet Diabetes Endocrinol 2018 Jun;6(6):500-514. Epub 2017 Nov 5 doi: 10.1016/S2213-8587(17)30325-X. PMID: 29102432
Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
Kallen ME, Naini BV
Arch Pathol Lab Med 2016 Sep;140(9):992-6. doi: 10.5858/arpa.2014-0595-RS. PMID: 27575268
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Clinical prediction guides

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Progress in Treating Advanced Thyroid Cancers in the Era of Targeted Therapy.
Lubitz CC, Sadow PM, Daniels GH, Wirth LJ
Thyroid 2021 Oct;31(10):1451-1462. Epub 2021 Jun 22 doi: 10.1089/thy.2020.0962. PMID: 33860688Free PMC Article
PD-L1 and thyroid cytology: A possible diagnostic and prognostic marker.
Dell'Aquila M, Granitto A, Martini M, Capodimonti S, Cocomazzi A, Musarra T, Fiorentino V, Pontecorvi A, Lombardi CP, Fadda G, Pantanowitz L, Larocca LM, Rossi ED
Cancer Cytopathol 2020 Mar;128(3):177-189. Epub 2019 Dec 10 doi: 10.1002/cncy.22224. PMID: 31821747
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Rare metastases of well-differentiated thyroid cancers: a systematic review.
Madani A, Jozaghi Y, Tabah R, How J, Mitmaker E
Ann Surg Oncol 2015 Feb;22(2):460-6. Epub 2014 Sep 6 doi: 10.1245/s10434-014-4058-y. PMID: 25192681
Gender differences in benign renal masses.
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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