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Recurrent respiratory papillomatosis(RRP)

MedGen UID:
216998
•Concept ID:
C1168198
•
Neoplastic Process
Synonyms: Adult-onset recurrent respiratory papillomatosis (type); AORRP (type); JORRP (type); Juvenile laryngeal papilloma; Juvenile-onset recurrent respiratory papillomatosis (type); Laryngeal papilloma, recurrent; RRP
SNOMED CT: Recurrent respiratory papillomatosis (472827002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018955
Orphanet: ORPHA60032

Definition

Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory tract infections, pneumonia, dysphagia, stridor, and/or failure to thrive. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent respiratory papillomatosis
Follow this link to review classifications for Recurrent respiratory papillomatosis in Orphanet.

Professional guidelines

PubMed

Biologics for the Treatment of Recurrent Respiratory Papillomatosis.
Allen CT
Otolaryngol Clin North Am 2021 Aug;54(4):769-777. Epub 2021 Jun 5 doi: 10.1016/j.otc.2021.05.002. PMID: 34099306Free PMC Article
Pharmacotherapy for recurrent respiratory papillomatosis (RRP): a treatment update.
Donne AJ, Kinshuck A
Expert Opin Pharmacother 2021 Oct;22(14):1901-1908. Epub 2021 Jul 5 doi: 10.1080/14656566.2021.1935870. PMID: 34080517
Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.
Sidell DR, Balakrishnan K, Best SR, Zur K, Buckingham J, De Alarcon A, Baroody FM, Bock JM, Boss EF, Bower CM, Campisi P, Chen SF, Clarke JM, Clarke KD, Cocciaglia A, Cotton RT, Cuestas G, Davis KL, DeFago VH, Dikkers FG, Dossans I, Florez W, Fox E, Friedman AD, Grant N, Hamdi O, Hogikyan ND, Johnson K, Johnson LB, Johnson RF, Kelly P, Klein AM, Lawlor CM, Leboulanger N, Levy AG, Lam D, Licameli GR, Long S, Lott DG, Manrique D, McMurray JS, Meister KD, Messner AH, Mohr M, Mudd P, Mortelliti AJ, Novakovic D, Ongkasuwan J, Peer S, Piersiala K, Prager JD, Pransky SM, Preciado D, Raynor T, Rinkel RNPM, Rodriguez H, Rodríguez VP, Russell J, Scatolini ML, Scheffler P, Smith DF, Smith LP, Smith ME, Smith RJH, Sorom A, Steinberg A, Stith JA, Thompson D, Thompson JW, Varela P, White DR, Wineland AM, Yang CJ, Zdanski CJ, Derkay CS
Laryngoscope 2021 Jun;131(6):E1941-E1949. Epub 2021 Jan 6 doi: 10.1002/lary.29343. PMID: 33405268Free PMC Article

Recent clinical studies

Etiology

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Infantile recurrent respiratory papillomatosis: review of adjuvant therapies.
Patel A, Orban N
J Laryngol Otol 2021 Nov;135(11):958-963. Epub 2021 Sep 2 doi: 10.1017/S0022215121002322. PMID: 34470689
The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Recurrent respiratory papillomatosis: update 2018.
Derkay CS, Bluher AE
Curr Opin Otolaryngol Head Neck Surg 2018 Dec;26(6):421-425. doi: 10.1097/MOO.0000000000000490. PMID: 30300210
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457

Diagnosis

The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Recurrent Respiratory Papillomatosis.
Frazier AA
Radiographics 2018 Nov-Dec;38(7):2150. doi: 10.1148/rg.2018184010. PMID: 30422770
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Lancet 1988 Dec 17;2(8625):1406. PMID: 2904531

Therapy

Update on Recurrent Respiratory Papillomatosis.
Derkay CS, Bluher AE
Otolaryngol Clin North Am 2019 Aug;52(4):669-679. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.011. PMID: 31078306
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
Photodynamic therapy for recurrent respiratory papillomatosis.
Lieder A, Khan MK, Lippert BM
Cochrane Database Syst Rev 2014 Jun 5;2014(6):CD009810. doi: 10.1002/14651858.CD009810.pub2. PMID: 24898010Free PMC Article
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Lancet 1988 Dec 17;2(8625):1406. PMID: 2904531

Prognosis

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Role of chemokines in HPV-induced cancers.
Israr M, DeVoti JA, Papayannakos CJ, Bonagura VR
Semin Cancer Biol 2022 Dec;87:170-183. Epub 2022 Nov 17 doi: 10.1016/j.semcancer.2022.11.010. PMID: 36402301
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article

Clinical prediction guides

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Smoking and Carcinoma Trends in Recurrent Respiratory Papillomatosis Patients.
Freeman T, Erickson E, Koch B, Young T, Allen D, Kim B, deSilva B, Matrka L
Ann Otol Rhinol Laryngol 2023 Nov;132(11):1380-1385. Epub 2023 Mar 6 doi: 10.1177/00034894231158459. PMID: 36879422
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population.
Carvalho AMAS, Brito DS, Cunha APA, Monteiro PM, Ferreira MB, Assis DSFR, Bentivi JO, Andrade MS, Vidal FCB, Salgado Filho N
Rev Inst Med Trop Sao Paulo 2021;63:e63. Epub 2021 Aug 16 doi: 10.1590/S1678-9946202163063. PMID: 34406288Free PMC Article
Pharmacotherapy for recurrent respiratory papillomatosis (RRP): a treatment update.
Donne AJ, Kinshuck A
Expert Opin Pharmacother 2021 Oct;22(14):1901-1908. Epub 2021 Jul 5 doi: 10.1080/14656566.2021.1935870. PMID: 34080517
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562

Recent systematic reviews

Intralesional cidofovir vs. bevacizumab for recurrent respiratory papillomatosis: a systematic review and indirect meta-analysis.
Zagzoog FH, Mogharbel AM, Alqutub A, Bukhari M, Almohizea MI
Eur Arch Otorhinolaryngol 2024 Feb;281(2):601-627. Epub 2023 Oct 13 doi: 10.1007/s00405-023-08279-0. PMID: 37831132
Recurrent Respiratory Papillomatosis Office versus Operating Room: Systematic Review and Meta-Analysis.
Chen S, Connors J, Zhang Y, Wang B, Vieira D, Shapira-Galitz Y, Garber D, Amin MR
Ann Otol Rhinol Laryngol 2021 Mar;130(3):234-244. Epub 2020 Aug 12 doi: 10.1177/0003489420949586. PMID: 32781827
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
San Giorgi MR, Helder HM, Lindeman RJ, de Bock GH, Dikkers FG
Laryngoscope 2016 Oct;126(10):2330-9. Epub 2016 Apr 26 doi: 10.1002/lary.25898. PMID: 27113025
Photodynamic therapy for recurrent respiratory papillomatosis.
Lieder A, Khan MK, Lippert BM
Cochrane Database Syst Rev 2014 Jun 5;2014(6):CD009810. doi: 10.1002/14651858.CD009810.pub2. PMID: 24898010Free PMC Article

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