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Trichilemmal Carcinoma

MedGen UID:
220406
•Concept ID:
C1266009
•
Neoplastic Process
Synonyms: Trichilemmal carcinoma; Trichilemmocarcinoma
SNOMED CT: Trichilemmal carcinoma (403929003); Trichilemmal carcinoma (128624000); Trichilemmocarcinoma (128624000)

Definition

A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrichilemmal Carcinoma

Professional guidelines

PubMed

Malignant hair follicle tumors of the periorbital region: A review of literature and suggestion of a management guideline.
Sia PI, Figueira E, Allende A, Selva D
Orbit 2016 Jun;35(3):144-56. Epub 2016 May 12 doi: 10.1080/01676830.2016.1176048. PMID: 27171562
Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars.
Ogawa R, Akaishi S, Hyakusoku H
Ann Plast Surg 2009 Jun;62(6):660-4. doi: 10.1097/SAP.0b013e31817e9d67. PMID: 19461281

Recent clinical studies

Etiology

Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review.
Baskurt D, Vural S, Ertekin SS, Baykal C
Int J Dermatol 2024 Jan;63(1):59-72. Epub 2023 Nov 14 doi: 10.1111/ijd.16890. PMID: 37964400
The molecular pathogenesis of Trichilemmal carcinoma.
Ha JH, Lee C, Lee KS, Pak CS, Sun CH, Koh Y, Chang H
BMC Cancer 2020 Jun 3;20(1):516. doi: 10.1186/s12885-020-07009-7. PMID: 32493317Free PMC Article
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck.
Wang LS, Handorf EA, Wu H, Liu JC, Perlis CS, Galloway TJ
Am J Clin Oncol 2017 Aug;40(4):429-432. doi: 10.1097/COC.0000000000000178. PMID: 25599317Free PMC Article
Trichilemmal carcinoma of the upper eyelid: a case report.
Lee JH, Shin YW, Oh YH, Lee YJ
Korean J Ophthalmol 2009 Dec;23(4):301-5. Epub 2009 Dec 4 doi: 10.3341/kjo.2009.23.4.301. PMID: 20046693Free PMC Article
Immunohistochemical stains in Mohs surgery: a review.
Stranahan D, Cherpelis BS, Glass LF, Ladd S, Fenske NA
Dermatol Surg 2009 Jul;35(7):1023-34. Epub 2009 Apr 16 doi: 10.1111/j.1524-4725.2009.01179.x. PMID: 19397647

Diagnosis

The molecular pathogenesis of Trichilemmal carcinoma.
Ha JH, Lee C, Lee KS, Pak CS, Sun CH, Koh Y, Chang H
BMC Cancer 2020 Jun 3;20(1):516. doi: 10.1186/s12885-020-07009-7. PMID: 32493317Free PMC Article
Locally aggressive trichilemmal carcinoma.
Maya-Rico AM, Jaramillo-Pulgarín C, Londoño-García Á, Peña-Zúñiga B
An Bras Dermatol 2018 Jul-Aug;93(4):579-581. doi: 10.1590/abd1806-4841.20187461. PMID: 30066770Free PMC Article
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck.
Wang LS, Handorf EA, Wu H, Liu JC, Perlis CS, Galloway TJ
Am J Clin Oncol 2017 Aug;40(4):429-432. doi: 10.1097/COC.0000000000000178. PMID: 25599317Free PMC Article
Onycholemmal carcinoma.
Alessi E, Coggi A, Gianotti R, Parafioriti A, Berti E
Am J Dermatopathol 2004 Oct;26(5):397-402. doi: 10.1097/00000372-200410000-00010. PMID: 15365373
Tumors of the pilosebaceous unit.
Waibel M, Blume U, Anhuth D, Almond-Roesler B, Orfanos CE
Skin Pharmacol 1994;7(1-2):90-3. doi: 10.1159/000211280. PMID: 8003331

Therapy

A case of trichilemmal carcinoma with distant metastases in a kidney transplantation patient.
Hiramatsu K, Sasaki K, Matsuda M, Hashimoto M, Eguchi T, Tomikawa S, Fujii T, Watanabe G
Transplant Proc 2015 Jan-Feb;47(1):155-7. doi: 10.1016/j.transproceed.2014.10.015. PMID: 25645796
Management of trichilemmal carcinoma: an update and comprehensive review of the literature.
Hamman MS, Brian Jiang SI
Dermatol Surg 2014 Jul;40(7):711-7. doi: 10.1111/dsu.0000000000000002. PMID: 25111341
Infiltrative trichilemmal carcinoma treated with 5% imiquimod cream.
Jo JH, Ko HC, Jang HS, Kim MB, Oh CK, Kwon KS
Dermatol Surg 2005 Aug;31(8 Pt 1):973-6. doi: 10.1097/00042728-200508000-00016. PMID: 16042947
Trichilemmal carcinoma in an African American.
Laochumroonvorapong P, Kokta V, Quan MB
Dermatol Surg 2002 Mar;28(3):284-6. doi: 10.1046/j.1524-4725.2002.01128.x. PMID: 11896784

Prognosis

Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review.
Baskurt D, Vural S, Ertekin SS, Baykal C
Int J Dermatol 2024 Jan;63(1):59-72. Epub 2023 Nov 14 doi: 10.1111/ijd.16890. PMID: 37964400
The molecular pathogenesis of Trichilemmal carcinoma.
Ha JH, Lee C, Lee KS, Pak CS, Sun CH, Koh Y, Chang H
BMC Cancer 2020 Jun 3;20(1):516. doi: 10.1186/s12885-020-07009-7. PMID: 32493317Free PMC Article
Merkel cell carcinoma with divergent differentiation.
Gaitskell K, Nassar S, Ibrahim H
Clin Exp Dermatol 2020 Apr;45(3):327-332. Epub 2019 Nov 13 doi: 10.1111/ced.14110. PMID: 31580510
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck.
Wang LS, Handorf EA, Wu H, Liu JC, Perlis CS, Galloway TJ
Am J Clin Oncol 2017 Aug;40(4):429-432. doi: 10.1097/COC.0000000000000178. PMID: 25599317Free PMC Article
Trichilemmal carcinoma: review of 8 cases.
Reis JP, Tellechea O, Cunha MF, Baptista AP
J Cutan Pathol 1993 Feb;20(1):44-9. doi: 10.1111/j.1600-0560.1993.tb01248.x. PMID: 8468416

Clinical prediction guides

A malignant proliferating trichilemmal cyst arising on the elbow of a man: A case report and review of the literature.
Lee DY, Han KM, Yoon JS
Medicine (Baltimore) 2023 Jun 23;102(25):e34035. doi: 10.1097/MD.0000000000034035. PMID: 37352060Free PMC Article
Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
Plaza JA, Ortega PF, Stockman DL, Suster S
J Cutan Pathol 2010 Apr;37(4):403-10. doi: 10.1111/j.1600-0560.2010.01517.x. PMID: 20377670
Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review.
Oyama N, Kaneko F
J Dermatol 2008 Dec;35(12):782-5. doi: 10.1111/j.1346-8138.2008.00569.x. PMID: 19239559
Onycholemmal carcinoma.
Alessi E, Coggi A, Gianotti R, Parafioriti A, Berti E
Am J Dermatopathol 2004 Oct;26(5):397-402. doi: 10.1097/00000372-200410000-00010. PMID: 15365373
Trichilemmal carcinoma: review of 8 cases.
Reis JP, Tellechea O, Cunha MF, Baptista AP
J Cutan Pathol 1993 Feb;20(1):44-9. doi: 10.1111/j.1600-0560.1993.tb01248.x. PMID: 8468416

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