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Colonic inertia

MedGen UID:
222475
•Concept ID:
C1257861
•
Sign or Symptom
Synonym: Colonic Inertia
 
HPO: HP:0012423

Definition

The inability of the colon to modify stool to an acceptable consistency and move the stool from the cecum to the rectosigmoid area at least once every three days. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColonic inertia

Professional guidelines

PubMed

Current Treatment Practices for Adult Patients with Constipation in Japan.
Kessoku T, Misawa N, Ohkubo H, Nakajima A
Digestion 2024;105(1):40-48. Epub 2023 Sep 11 doi: 10.1159/000533548. PMID: 37696258Free PMC Article
The magnitude and management of functional constipation at pediatric gastroenterology clinics: A survey study of various countries.
Osatakul S, Benninga MA, Thapar N, Treepongkaruna S, Puetpaiboon A
J Gastroenterol Hepatol 2022 Jan;37(1):89-96. Epub 2021 Sep 13 doi: 10.1111/jgh.15671. PMID: 34425028
Surgical management of colonic inertia.
Beck DE, Fazio VW, Jagelman DG, Lavery IC
South Med J 1989 Mar;82(3):305-9. doi: 10.1097/00007611-198903000-00007. PMID: 2646727

Recent clinical studies

Etiology

Prucalopride for chronic constipation.
Lacy BE, Loew B, Crowell MD
Drugs Today (Barc) 2009 Dec;45(12):843-53. doi: 10.1358/dot.2009.45.12.1423115. PMID: 20135019
Small intestinal motility.
Jones MP, Wessinger S
Curr Opin Gastroenterol 2006 Mar;22(2):111-6. doi: 10.1097/01.mog.0000203867.33008.52. PMID: 16462165
Role of colonic motility in guiding therapy in patients with constipation.
Snape WJ Jr
Dig Dis 1997;15 Suppl 1:104-11. doi: 10.1159/000171625. PMID: 9177949
Surgery for constipation: a review.
Pfeifer J, Agachan F, Wexner SD
Dis Colon Rectum 1996 Apr;39(4):444-60. doi: 10.1007/BF02054062. PMID: 8878507
Surgical management of colonic inertia.
Beck DE, Fazio VW, Jagelman DG, Lavery IC
South Med J 1989 Mar;82(3):305-9. doi: 10.1097/00007611-198903000-00007. PMID: 2646727

Diagnosis

Functional Constipation and Obstructed Defecation.
O'Donnell MT, Haviland SM
Surg Clin North Am 2024 Jun;104(3):565-578. Epub 2023 Dec 14 doi: 10.1016/j.suc.2023.11.007. PMID: 38677821
Current Treatment Practices for Adult Patients with Constipation in Japan.
Kessoku T, Misawa N, Ohkubo H, Nakajima A
Digestion 2024;105(1):40-48. Epub 2023 Sep 11 doi: 10.1159/000533548. PMID: 37696258Free PMC Article
Refractory Constipation: How to Evaluate and Treat.
Camilleri M, Brandler J
Gastroenterol Clin North Am 2020 Sep;49(3):623-642. Epub 2020 Jun 14 doi: 10.1016/j.gtc.2020.05.002. PMID: 32718574
Slow transit constipation.
Bharucha AE, Phillips SF
Gastroenterol Clin North Am 2001 Mar;30(1):77-95. doi: 10.1016/s0889-8553(05)70168-0. PMID: 11394038
Clinical management of intractable constipation.
Camilleri M, Thompson WG, Fleshman JW, Pemberton JH
Ann Intern Med 1994 Oct 1;121(7):520-8. doi: 10.7326/0003-4819-121-7-199410010-00008. PMID: 8067650

Therapy

Current Treatment Practices for Adult Patients with Constipation in Japan.
Kessoku T, Misawa N, Ohkubo H, Nakajima A
Digestion 2024;105(1):40-48. Epub 2023 Sep 11 doi: 10.1159/000533548. PMID: 37696258Free PMC Article
Personalized medicine in functional gastrointestinal disorders: Understanding pathogenesis to increase diagnostic and treatment efficacy.
Wang XJ, Camilleri M
World J Gastroenterol 2019 Mar 14;25(10):1185-1196. doi: 10.3748/wjg.v25.i10.1185. PMID: 30886502Free PMC Article
Colonic manometry and colonic scintigraphy as a diagnostic tool for children with severe constipation.
Mugie SM, Perez ME, Burgers R, Hingsbergen EA, Punati J, Mousa H, Benninga MA, Lorenzo CD
J Pediatr Gastroenterol Nutr 2013 Nov;57(5):598-602. doi: 10.1097/MPG.0b013e31829e0bdd. PMID: 24177783
Prucalopride for chronic constipation.
Lacy BE, Loew B, Crowell MD
Drugs Today (Barc) 2009 Dec;45(12):843-53. doi: 10.1358/dot.2009.45.12.1423115. PMID: 20135019
Constipation: a physiological approach.
Thompson WG
Can J Gastroenterol 2000 Nov;14 Suppl D:155D-162D. doi: 10.1155/2000/391807. PMID: 11110630

Prognosis

Functional Constipation and Obstructed Defecation.
O'Donnell MT, Haviland SM
Surg Clin North Am 2024 Jun;104(3):565-578. Epub 2023 Dec 14 doi: 10.1016/j.suc.2023.11.007. PMID: 38677821
The management of the slow transit constipation in the laparoscopic era.
De Marco P, Militello G, Tutino R, Trapani A, Rizzo G, Kabhuli K, Falco N, Licari L, Salamone G, Gulotta G
G Chir 2018 Sep-Oct;34(5):297-302. PMID: 30444478
American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice.
Camilleri M, Bharucha AE, di Lorenzo C, Hasler WL, Prather CM, Rao SS, Wald A
Neurogastroenterol Motil 2008 Dec;20(12):1269-82. doi: 10.1111/j.1365-2982.2008.01230.x. PMID: 19019032
Small bowel transit does not correlate with outcome of surgery in patients with colonic inertia.
Zmora O, Colquhoun P, Katz J, Efron J, Weiss EG, Nogueras JJ, Vernava AM 3rd, Wexner SD
Surg Innov 2005 Sep;12(3):215-8. doi: 10.1177/155335060501200305. PMID: 16224641
Laparoscopic creation of stomas.
Oliveira L, Reissman P, Nogueras J, Wexner SD
Surg Endosc 1997 Jan;11(1):19-23. doi: 10.1007/s004649900287. PMID: 8994982

Clinical prediction guides

Massive Submucosal Ganglia in Colonic Inertia.
Naemi K, Stamos MJ, Wu ML
Arch Pathol Lab Med 2018 Feb;142(2):208-212. Epub 2017 Oct 5 doi: 10.5858/arpa.2016-0551-OA. PMID: 28981370
The effect of chronic constipation on the development of inguinal herniation.
Kartal A, Yalcın M, Citgez B, Uzunkoy A
Hernia 2017 Aug;21(4):531-535. Epub 2017 Apr 9 doi: 10.1007/s10029-017-1604-0. PMID: 28393306
Colonic manometry and colonic scintigraphy as a diagnostic tool for children with severe constipation.
Mugie SM, Perez ME, Burgers R, Hingsbergen EA, Punati J, Mousa H, Benninga MA, Lorenzo CD
J Pediatr Gastroenterol Nutr 2013 Nov;57(5):598-602. doi: 10.1097/MPG.0b013e31829e0bdd. PMID: 24177783
Laparoscopic total colectomy for colonic inertia: surgical and functional results.
Pinedo G, Zarate AJ, Garcia E, Molina ME, Lopez F, Zúñiga A
Surg Endosc 2009 Jan;23(1):62-5. Epub 2008 Apr 10 doi: 10.1007/s00464-008-9901-4. PMID: 18401647
American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice.
Camilleri M, Bharucha AE, di Lorenzo C, Hasler WL, Prather CM, Rao SS, Wald A
Neurogastroenterol Motil 2008 Dec;20(12):1269-82. doi: 10.1111/j.1365-2982.2008.01230.x. PMID: 19019032

Recent systematic reviews

Surgery for chronic idiopathic constipation: pediatric and adult patients - a systematic review.
Swanson KA, Phelps HM, Chapman WC Jr, Glasgow SC, Smith RK, Joerger S, Utterson EC, Shakhsheer BA
J Gastrointest Surg 2024 Feb;28(2):170-178. Epub 2024 Feb 5 doi: 10.1016/j.gassur.2023.12.008. PMID: 38445940

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